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Neurone im Raum mit iBrain Logo

Alumni

Graduated 19.06.2019

PhD thesis
Regulation of myelination in the developing and regenerating CNS.

Supervisors

Publications

  1. Protective effects of 4-aminopyridine in experimental optic neuritis and multiple sclerosis. Michael Dietrich, Valeria Koska, Christina Hecker, Peter Göttle, Alexander M Hilla, Annemarie Heskamp, Klaudia Lepka, Andrea Issberner, Angelika Hallenberger, Christine Baksmeier, Julia Steckel, Lisanne Balk, Benjamin Knier, Thomas Korn, Joachim Havla, Elena H Martínez-Lapiscina, Nuria Solà-Valls, Praveena Manogaran, Elisabeth D Olbert, Sven Schippling, Andrés Cruz-Herranz, Hao Yiu, Julia Button, Natalia Gonzalez Caldito, Charlotte von Gall, Anne K Mausberg, Mark Stettner, Hannah G Zimmermann, Friedemann Paul, Alexander U Brandt, Patrick Küry, Norbert Goebels, Orhan Aktas, Carsten Berndt, Shiv Saidha, Ari J Green, Peter A Calabresi, Dietmar Fischer, Hans-Peter Hartung, Philipp Albrecht. Brain. 2020 Apr 1;143(4):1127-1142. doi: 10.1093/brain/awaa062. PubMed

  2. NMDAR encephalitis: passive transfer from man to mouse by a recombinant antibody. Malviya M, Barman S, Golombeck KS, Planagumà J, Mannara F, Strutz-Seebohm N, Wrzos C, Demir F, Baksmeier C, Steckel J, Falk KK, Gross CC, Kovac S, Bönte K, Johnen A, Wandinger KP, Martín-García E, Becker AJ, Elger CE, Klöcker N, Wiendl H, Meuth SG, Hartung HP, Seebohm G, Leypoldt F, Maldonado R, Stadelmann C, Dalmau J, Melzer N, Goebels N. Ann Clin Transl Neurol. 2017 Oct 3;4(11):768-783. doi: 10.1002/acn3.444. eCollection 2017 Nov. PubMed
  3. Epigallocatechin gallate (EGCG) inhibits adhesion and migration of neural progenitor cells in vitro. Barenys M, Gassmann K, Baksmeier C, Heinz S, Reverte I, Schmuck M, Temme T, Bendt F, Zschauer TC, Rockel TD, Unfried K, Wätjen W, Sundaram SM, Heuer H, Colomina MT, Fritsche E. Arch Toxicol. 2017 Feb;91(2):827-837. doi: 10.1007/s00204-016-1709-8. Epub 2016 Apr 26. PubMed
  4. Dose-dependent inhibition of demyelination and microglia activation by IVIG. Winter M, Baksmeier C, Steckel J, Barman S, Malviya M, Harrer-Kuster M, Hartung HP, Goebels N. Ann Clin Transl Neurol. 2016 Sep 23;3(11):828-843. eCollection 2016. PubMed

Graduated 25.02.2021

PhD thesis
Heterogeneous fate choice of neural stem cells in the damaged and intact central nervous system.

Supervisors

Publications

  1. Secretome Analysis of Mesenchymal Stem Cell Factors Fostering Oligodendroglial Differentiation of Neural Stem Cells In Vivo. Iria Samper Agrelo, Jessica Schira-Heinen, Felix Beyer, Janos Groh, Christine Bütermann, Veronica Estrada, Gereon Poschmann, Ana Bribian, Janusz J Jadasz, Laura Lopez-Mascaraque, David Kremer, Rudolf Martini, Hans Werner Müller, Hans Peter Hartung, James Adjaye, Kai Stühler, Patrick Küry. Int J Mol Sci. 2020 Jun 18;21(12):E4350.doi: 10.3390/ijms21124350. PubMed
  2. Imaging of Intracellular ATP in Organotypic Tissue Slices of the Mouse Brain using the FRET-based Sensor ATeam1.03YEMK. Rodrigo Lerchundi, Karl W Kafitz, Marcel Färfers, Felix Beyer, Na Huang, Christine R Rose. J Vis Exp. 2019 Dec 19;(154). doi: 10.3791/60294. PubMed
  3. Heterogeneous fate choice of genetically modulated adult neural stem cells in gray and white matter of the central nervous system. Beyer F, Jadasz J, Samper Agrelo I, Schira-Heinen J, Groh J, Manousi A, Bütermann C, Estrada V, Reiche L, Cantone M, Vera J, Viganò F, Dimou L, Müller HW, Hartung HP, Küry P. Glia. 2020 Feb;68(2):393-406. doi: 10.1002/glia.23724. Epub 2019 Oct 21. PubMed
  4. A gene regulatory architecture that controls region-independent dynamics of oligodendrocyte differentiation. Martina Cantone, Melanie Küspert, Simone Reiprich, Xin Lai, Martin Eberhardt, Peter Göttle, Felix Beyer, Kasum Azim, Patrick Küry , Michael Wegner Julio Vera. Glia. 2019 May;67(5):825-843. doi: 10.1002/glia.23569. Epub 2019 Feb 7. PubMed
  5. Do Neural Stem Cells Have a Choice? Heterogenic Outcome of Cell Fate Acquisition in Different Injury Models. Beyer F, Samper Agrelo I, Küry P. Int J Mol Sci. 2019 Jan 21;20(2). pii: E455. doi: 10.3390/ijms20020455. PubMed
  6. Human mesenchymal factors induce rat hippocampal- and human neural stem cell dependent oligodendrogenesis. Jadasz JJ, Tepe L, Beyer F, Samper Agrelo I, Akkermann R, Spitzhorn LS, Silva ME, Oreffo ROC, Hartung HP, Prigione A, Rivera FJ, Adjaye J, Küry P. Glia. 2018 Jan;66(1):145-160. doi: 10.1002/glia.23233. Epub 2017 Sep 22. PubMed
  7. Heterogeneous populations of neural stem cells contribute to myelin repair. Rainer Akkermann, Felix Beyer, Patrick Küry. Neural Regen Res. 2017 Apr;12(4):509-517. doi: 10.4103/1673-5374.204999. PubMed
  8. Novel approaches for the development of peripheral nerve regenerative therapies. Felix Beyer, Patrick Küry. Neural Regen Res. 2015 Nov;10(11):1743-5. doi: 10.4103/1673-5374.170298. PubMed
  9. Fingolimod induces the transition to a nerve regeneration promoting Schwann cell phenotype. Heinen A, Beyer F, Tzekova N, Hartung HP, Küry P. Exp Neurol. 2015 Sep;271:25-35. doi: 10.1016/j.expneurol.2015.05.002. Epub 2015 May 7. PubMed
  10. Intrinsically active and pacemaker neurons in pluripotent stem cell-derived neuronal populations. Illes S, Jakab M, Beyer F, Gelfert R, Couillard-Despres S, Schnitzler A, Ritter M, Aigner L. Stem Cell Reports. 2014 Feb 20;2(3):323-36. doi: 10.1016/j.stemcr.2014.01.006. eCollection 2014 Mar 11. PubMed

Graduated 29.01.2020

PhD thesis
Role of adhesion molecules in synapse formation, function and plasticity.

Supervisors

Publications

  1. A delay in vesicle endocytosis by a C-terminal fragment of N-cadherin enhances Aβ synaptotoxicity. Zenghui Teng, Georgia-Ioanna Kartalou, Sushma Dagar, Patrick C Fraering, Volkmar Lessmann, Kurt Gottmann. Cell Death Discov. 2023 Dec 8;9(1):444. doi: 10.1038/s41420-023-01739-w. PubMed
  2. Transsynaptic N-Cadherin Adhesion Complexes Control Presynaptic Vesicle and Bulk Endocytosis at Physiological Temperature. Dagar S, Teng Z, Gottmann K. Front Cell Neurosci. 2021 Oct 7;15:713693. doi: 10.3389/fncel.2021.713693. eCollection 2021. PubMed
  3. Differential Properties of the Synaptogenic Activities of the Neurexin Ligands Neuroligin1 and LRRTM2. Sushma Dagar, Kurt Gottmann. Front Mol Neurosci. 2019 Nov 8;12:269. doi: 10.3389/fnmol.2019.00269. eCollection 2019. PubMed
  4. Astrocyte lineage cells are essential for functional neuronal differentiation and synapse maturation in human iPSC-derived neural networks. Simon D Klapper, Pretty Garg, Sushma Dagar, Kerstin Lenk, Kurt Gottmann, Katja Nieweg. Glia. 2019 Oct;67(10):1893-1909. doi: 10.1002/glia.23666. Epub 2019 Jun 27. PubMed
  5. Release activity-dependent control of vesicle endocytosis by the synaptic adhesion molecule N-cadherin. Bernd van Stegen, Sushma Dagar, Kurt Gottmann. Sci Rep. 2017 Jan 20;7:40865. doi: 10.1038/srep40865. PubMed

Graduated 23.03.2016

PhD thesis
Interactions of dopaminergic and histaminergic systems in health and disease.

Supervisors

Publications

  1. Tachykinins amplify the action of capsaicin on central histaminergic neurons. O A Sergeeva, K Mazur, A Kernder, H L Haas, R De Luca. Peptides. 2021 Dec 24;170729. doi: 10.1016/j.peptides.2021.170729. Online ahead of print. PubMed

  2. Mechanisms of N-oleoyldopamine activation of central histaminergic neurons. De Luca R, Mazur K, Kernder A, Suvorava T, Kojda G, Haas HL, Sergeeva OA. Neuropharmacology. 2018 Dec;143:327-338. doi: 10.1016/j.neuropharm.2018.09.006. Epub 2018 Sep 13. PubMed

  3. N-oleoyldopamine modulates activity of midbrain dopaminergic neurons through multiple mechanisms. Sergeeva OA, De Luca R, Mazur K, Chepkova AN, Haas HL, Bauer A. Neuropharmacology. 2017 Jun;119:111-122. doi: 10.1016/j.neuropharm.2017.04.011. Epub 2017 Apr 9. PubMed

  4. Identification of histaminergic neurons through histamine 3 receptor-mediated autoinhibition. De Luca R, Suvorava T, Yang D, Baumgärtel W, Kojda G, Haas HL, Sergeeva OA. Neuropharmacology. 2016 Jul;106:102-15. doi: 10.1016/j.neuropharm.2015.08.025. Epub 2015 Aug 19. PubMed

  5. Associations among Exposure to Methylmercury, Reduced Reelin Expression, and gender in the Cerebellum of Developing Mice. Biamonte F, Latini L, Giorgi FS, Zingariello M, Marino R, De Luca R, D'Ilio S, Majorani C, Petrucci F, Violante N, Senofonte O, Molinari M, Keller F. Neurotoxicology. 2014 Dec;45:67-80. doi: 10.1016/j.neuro.2014.09.006. Epub 2014 Oct 14. PubMed

  6. Acid-Sensing Hypothalamic Neurons Controlling Arousal. Kernder A, De Luca R, Yanovsky Y, Haas HL, Sergeeva OA. 2014 Aug;34(6):777-89. doi: 10.1007/s10571-014-0065-6. Epub 2014 May 6. PubMed

Graduated 16.04.2021

PhD thesis
Characterization of the intrathecal humoral immune response in inflammatory CNS diseases.

Supervisors

Graduated 25.10.2022

PhD thesis
Blood-Based Single Particle Analysis for Diagnosis of Alzheimer's Disease and Parkinson's Disease.

Supervisors

Publications

  1. Quantitative detection of α-Synuclein and Tau oligomers and other aggregates by digital single particle counting. Lara Blömeke, Marlene Pils, Victoria Kraemer-Schulien, Alexandra Dybala, Anja Schaffrath, Andreas Kulawik, Fabian Rehn, Anneliese Cousin, Volker Nischwitz, Johannes Willbold, Rebecca Zack, Thomas F Tropea, Tuyen Bujnicki, Gültekin Tamgüney, Daniel Weintraub, David Irwin, Murray Grossman, David A Wolk, John Q Trojanowski, Oliver Bannach, Alice Chen-Plotkin, Dieter Willbold. NPJ Parkinsons Dis. 2022 Jun 2;8(1):68. doi: 10.1038/s41531-022-00330-x. PubMed

  2. Oral and intravenous transmission of α-synuclein fibrils to mice. Lohmann S, Bernis ME, Tachu BJ, Ziemski A, Grigoletto J, Tamgüney G. Acta Neuropathol. 2019 Oct;138(4):515-533. doi: 10.1007/s00401-019-02037-5. Epub 2019 Jun 22. PMID: 31230104 PubMed

Graduated 28.04.2023

PhD Thesis
Gap junctional coupling under ischemic conditions.

Supervisors

Publications

  1. Inward Operation of Sodium-Bicarbonate Cotransporter 1 Promotes Astrocytic Na+ Loading and Loss of ATP in Mouse Neocortex during Brief Chemical Ischemia. Katharina Everaerts, Pawan Thapaliya, Nils Pape, Simone Durry, Sara Eitelmann, Eleni Roussa, Ghanim Ullah, Christine R Rose. Cells. 2023 Nov 21;12(23):2675. doi: 10.3390/cells12232675. PubMed
  2. Ca2+-dependent rapid uncoupling of astrocytes upon brief metabolic stress. Sara Eitelmann, Katharina Everaerts, Laura Petersilie, Christine R Rose, Jonathan Stephan. Front Cell Neurosci. 2023 Oct 11:17:1151608. doi: 10.3389/fncel.2023.1151608. eCollection 2023. PubMed
  3. Changes in Astroglial K + upon Brief Periods of Energy Deprivation in the Mouse Neocortex. Sara Eitelmann, Jonathan Stephan, Katharina Everaerts, Simone Durry, Nils Pape, Niklas J Gerkau, Christine R Rose. Int J Mol Sci. 2022 Apr 27;23(9):4836. doi: 10.3390/ijms23094836. PubMed
  4. Approaches to Study Gap Junctional Coupling. Stephan J, Eitelmann S, Zhou M. Front Cell Neurosci. 2021 Mar 10;15:640406. doi: 10.3389/fncel.2021.640406. eCollection 2021. PubMed
  5. Altered Gap Junction Network Topography in Mouse Models for Human Hereditary Deafness. Sara Eitelmann, Laura Petersilie, Christine R Rose, Jonathan Stephan. Int J Mol Sci. 2020 Oct 6;21(19):7376. doi: 10.3390/ijms21197376. PubMed
  6. A Vector-Based Method to Analyze the Topography of Glial Networks. Sara Eitelmann, Jan J Hirtz, Jonathan Stephan. Int J Mol Sci. 2019 Jun 10;20(11):2821. doi: 10.3390/ijms20112821. PubMed

Graduated 04.11.2020

PhD thesis
Establishment of an Adverse Outcome Pathway-informed testing battery for predicting Parkinsonian Motor Deficits in vitro.

Supervisor

Publications

  1. Animal Model for Leigh Syndrome. El-Desouky S, Taalab YM, El-Gamal M, Mohamed W, Salama M. Methods Mol Biol. 2019;2011:451-464. doi: 10.1007/978-1-4939-9554-7_27. PMID: 31273716 PubMed
  2. Literature review and appraisal on alternative neurotoxicity testing methods. Masjosthusmann S, Barenys M, El‐Gamal M, Geerts L, Gerosa L, Gorreja A, Kühne B, Marchetti N, Tigges J, Viviani B, Witters H. EFSA Supporting Publications. 2018 Apr;15(4):1410E.

Graduated 22.04.2021

PhD thesis
The role of FeS cluster coordination in glutaredoxins on physiology and pathology.

Supervisor

  • PD Dr. Casten Berndt

  • Prof. Dr. Andreas Reichert

Publications

  1. The G127V variant of the prion protein interferes with dimer formation in vitro but not in cellulo. Sangeetham SB, Engelke AD, Fodor E, Krausz SL, Tatzelt J, Welker E. Sci Rep. 2021 Feb 4;11(1):3116. doi: 10.1038/s41598-021-82647-w. PubMed

  2. Molecular basis for the distinct functions of redox-active and FeS-transfering glutaredoxins. Daniel Trnka, Anna D Engelke, Manuela Gellert, Anna Moseler, Md Faruq Hossain, Tobias T Lindenberg, Luca Pedroletti, Benjamin Odermatt, João V de Souza, Agnieszka K Bronowska, Tobias P Dick, Uli Mühlenhoff, Andreas J Meyer, Carsten Berndt, Christopher Horst Lillig. Nat Commun. 2020 Jul 10;11(1):3445. doi: 10.1038/s41467-020-17323-0. PubMed

  3. Dimerization of the cellular prion protein inhibits propagation of scrapie prions. Engelke AD, Gonsberg A, Thapa S, Jung S, Ulbrich S, Seidel R, Basu S, Multhaup G, Baier M, Engelhard M, Schätzl HM, Winklhofer KF, Tatzelt J. J Biol Chem. 2018 May 25;293(21):8020-8031. doi: 10.1074/jbc.RA117.000990. Epub 2018 Apr 10. PubMed

  4. Nimodipine confers clinical improvement in two models of experimental autoimmune encephalomyelitis. Ingwersen J, De Santi L, Wingerath B, Graf J, Koop B, Schneider R, Hecker C, Schröter F, Bayer M, Engelke AD, Dietrich M, Albrecht P, Hartung HP, Annunziata P, Aktas O, Prozorovski T. J Neurochem. 2018 Feb 23. doi: 10.1111/jnc.14324. PubMed

Graduated 26.02.2021

PhD Thesis
Spontaneous Na+ fluctuations in the neonatal mouse brain.

Supervisors

Publications

  1. Novel algorithms for improved detection and analysis of fluorescent signal fluctuations. Gebhard Stopper, Laura C Caudal, Phillip Rieder, Davide Gobbo, Laura Stopper, Lisa Felix, Katharina Everaerts, Xianshu Bai, Christine R Rose, Anja Scheller, Frank Kirchhoff. 2023 Nov;475(11):1283-1300. doi: 10.1007/s00424-023-02855-3. Epub 2023 Sep 13. PubMed ID: 37700120 PubMed

  2. On the Origin of Ultraslow Spontaneous Na + Fluctuations in Neurons of the Neonatal Forebrain. Carlos Perez, Lisa Felix, Simone Durry, Christine R Rose, Ghanim Ullah. J Neurophysiol. 2021 Feb 1;125(2):408-425. doi: 10.1152/jn.00373.2020. Epub 2020 Nov 25. PubMed

  3. Correction: Felix, L.; Ziemens, D.; Seifert, G.; Rose, C.R. Spontaneous. Ultraslow Na + Fluctuations in the Neonatal Mouse Brain. Lisa Felix, Daniel Ziemens, Gerald Seifert, Christine R Rose.  Cells 2020, 9, 102. Cells. 2020 Oct 30;9(11):E2380. doi: 10.3390/cells9112380. PubMed

  4. Sodium Fluctuations in Astroglia and Their Potential Impact on Astrocyte Function. Lisa Felix, Andrea Delekate, Gabor C Petzold, Christine R Rose. Front Physiol. 2020 Aug 12;11:871. doi: 10.3389/fphys.2020.00871. eCollection 2020. PubMed

  5. Astrocytes of the early postnatal brain. Felix L, Stephan J, Rose CR. Eur J Neurosci. 2020 May 14. doi: 10.1111/ejn.14780. Online ahead of print. PMID: 32406559 PubMed

  6. Spontaneous Ultraslow Na+ Fluctuations in the Neonatal Mouse Brain. Felix L, Ziemens D, Seifert G, Rose CR. Cells. 2019 Dec 31;9(1):102. doi: 10.3390/cells9010102. PMID: 31906100 PubMed

  7. Astroglial Glutamate Signaling and Uptake in the Hippocampus. Rose CR, Felix L, Zeug A, Dietrich D, Reiner A, Henneberger C. Front Mol Neurosci. 2018 Jan 17;10:451. doi: 10.3389/fnmol.2017.00451. eCollection 2017. PMID: 29386994 PubMed

Graduated 11.02.2016

PhD thesis
Differentiation and Characterization of Human Induced Pluripotent Stem Cell derived Astrocytes.

Supervisor

Publications

  1. Astrocyte lineage cells are essential for functional neuronal differentiation and synapse maturation in human iPSC-derived neural networks. Klapper SD, Garg P, Dagar S, Lenk K, Gottmann K, Nieweg K. Glia. 2019 Oct;67(10):1893-1909.doi: 10.1002/glia.23666. Epub 2019 Jun 27. PubMed
  2. The gut-brain axis in Parkinson's disease: A focus on the transport of α-Synuclein.  Sivaraj Mohana Sundaram, Pretty Garg. Mov Disord. 2019 Oct;34(10):1479. doi: 10.1002/mds.27842. Epub 2019 Sep 4. PubMed

Graduated 30.10.2023

PhD thesis
Different means of glial activation in neurodegenerative diseases.

Supervisors

Publications

  1. Transgenic expression of the HERV-W envelope protein leads to polarized glial cell populations and a neurodegenerative environment. Joel Gruchot, Isabel Lewen, Michael Dietrich, Laura Reiche, Mustafa Sindi, Christina Hecker, Felisa Herrero, Benjamin Charvet, Ulrike Weber-Stadlbauer, Hans-Peter Hartung, Philipp Albrecht, Hervé Perron, Urs Meyer, Patrick Küry. Proc Natl Acad Sci U S A. 2023 Sep 19;120(38):e2308187120. doi: 10.1073/pnas.2308187120. Epub 2023 Sep 11. PubMed

  2. A Novel Ex Vivo Model to Study Therapeutic Treatments for Myelin Repair following Ischemic Damage. Luisa Werner, Michael Gliem, Nicole Rychlik, Goran Pavic, Laura Reiche, Frank Kirchhoff, Markley Silva Oliveira Junior, Joel Gruchot, Sven G Meuth, Patrick Küry, Peter Göttle. Int J Mol Sci. 2023 Jun 30;24(13):10972. doi: 10.3390/ijms241310972. PubMed

  3. Teriflunomide as a therapeutic means for myelin repair. Peter Göttle, Janos Groh, Laura Reiche, Joel Gruchot, Nicole Rychlik, Luisa Werner, Iria Samper Agrelo, Rainer Akkermann, Annika Zink, Alessandro Prigione, Hans-Peter Hartung, Rudolf Martini, Patrick Küry. J Neuroinflammation. 2023 Jan 7;20(1):7. doi: 10.1186/s12974-022-02686-6. PubMed

  4. Susceptibility and resilience to maternal immune activation are associated with differential expression of endogenous retroviral elements. Felisa Herrero, Flavia S Mueller, Joel Gruchot, Patrick Küry, Ulrike Weber-Stadlbauer, Urs Meyer. Brain Behav Immun. 2023 Jan;107:201-214. doi: 10.1016/j.bbi.2022.10.006. Epub 2022 Oct 12. PubMed

  5. Interplay between activation of endogenous retroviruses and inflammation as common pathogenic mechanism in neurological and psychiatric disorders. Joel Gruchot, Felisa Herrero, Ulrike Weber-Stadlbauer, Urs Meyer, Patrick Küry. Brain Behav Immun. 2023 Jan;107:242-252. doi: 10.1016/j.bbi.2022.10.007. Epub 2022 Oct 18. PubMed

  6. Cladribine treatment improves cortical network functionality in a mouse model of autoimmune encephalomyelitis. Christina B Schroeter, Leoni Rolfes, K S Sophie Gothan, Joel Gruchot, Alexander M Herrmann, Stefanie Bock, Luca Fazio, Antonia Henes, Venu Narayanan, Steffen Pfeuffer, Christopher Nelke, Saskia Räuber, Niklas Huntemann, Eduardo Duarte-Silva, Vera Dobelmann, Petra Hundehege, Heinz Wiendl, Katharina Raba, Patrick Küry, David Kremer, Tobias Ruck, Thomas Müntefering, Thomas Budde, Manuela Cerina, Sven G Meuth. J Neuroinflammation. 2022 Nov 8;19(1):270. doi: 10.1186/s12974-022-02588-7. PubMed

  7. Siponimod Modulates the Reaction of Microglial Cells to Pro-Inflammatory Stimulation. Joel Gruchot, Ferdinand Lein, Isabel Lewen, Laura Reiche, Vivien Weyers, Patrick Petzsch, Peter Göttle, Karl Köhrer, Hans-Peter Hartung, Patrick Küry, David Kremer. J Neuroinflammation. 2022 Nov 8;19(1):270. doi: 10.1186/s12974-022-02588-7. PubMed

  8. Deficiency of the two-pore potassium channel KCNK9 impairs intestinal epithelial cell survival and aggravates dextran sodium sulfate-induced colitis: The role of K2P channels in intestinal inflammation. Steffen Pfeuffer, Thomas Müntefering, Leoni Rolfes, Frederike Anne Straeten, Susann Eichler, Joel Gruchot, Vera Dobelmann, Tim Prozorovski, Boris Görg, Mihael Vucur, Carsten Berndt, Patrick Küry, Tobias Ruck, Stefan Bittner, Dominik Bettenworth, Thomas Budde, Tom Lüdde, Sven G Meuth. Cell Mol Gastroenterol Hepatol. 2022;14(6):1199-1211. doi: 10.1016/j.jcmgh.2022.08.003. Epub 2022 Aug 13. PubMed

  9. Myelin repair is fostered by the corticosteroid medrysone specifically acting on astroglial subpopulations. Markley Silva Oliveira Junior, Jessica Schira-Heinen, Laura Reiche, Seulki Han, Vanessa Cristina Meira de Amorim, Isabel Lewen, Joel Gruchot, Peter Göttle, Rainer Akkermann, Kasum Azim, Patrick Küry. EBioMedicine. 2022 Aug 8;83:104204. doi: 10.1016/j.ebiom.2022.104204. Online ahead of print. PubMed

  10. Increased Remyelination and Proregenerative Microglia Under Siponimod Therapy in Mechanistic Models. Michael Dietrich, Christina Hecker, Elodie Martin, Dominique Langui, Michael Gliem, Bruno Stankoff, Catherine Lubetzki, Joel Gruchot, Peter Göttle, Andrea Issberner, Milad Nasiri, Pamela Ramseier, Christian Beerli, Sarah Tisserand, Nicolau Beckmann, Derya Shimshek, Patrick Petzsch, David Akbar, Bodo Levkau, Holger Stark, Karl Köhrer, Hans-Peter Hartung, Patrick Küry, Sven Günther Meuth, Marc Bigaud, Bernard Zalc, Philipp Albrecht. Neurol Neuroimmunol Neuroinflamm. 2022 Mar 30;9(3):e1161. doi: 10.1212/NXI.0000000000001161. Print 2022 May. PubMed

  11. Translational value of choroid plexus imaging for tracking neuroinflammation in mice and humans. Vinzenz Fleischer, Gabriel Gonzalez-Escamilla, Dumitru Ciolac, Philipp Albrecht, Patrick Küry, Joel Gruchot, Michael Dietrich, Christina Hecker, Thomas Müntefering, Stefanie Bock, Mohammadsaleh Oshaghi, Angela Radetz, Manuela Cerina, Julia Krämer, Lydia Wachsmuth, Cornelius Faber, Hans Lassmann, Tobias Ruck, Sven G Meuth, Muthuraman Muthuraman, Sergiu Groppa. Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2025000118. doi: 10.1073/pnas.2025000118. PubMed

  12. Identification of novel myelin repair drugs by modulation of oligodendroglial differentiation competence. Anastasia Manousi, Peter Göttle, Laura Reiche, Qiao-Ling Cui, Luke M Healy, Rainer Akkermann, Joel Gruchot, Jessica Schira-Heinen, Jack P Antel, Hans-Peter Hartung, Patrick Küry. EBioMedicine. 2021 Mar;65:103276. doi: 10.1016/j.ebiom.2021.103276. Epub 2021 Mar 10. PubMed

  13. Meeting report: "Human endogenous retroviruses: HERVs or transposable elements in autoimmune, chronic inflammatory and degenerative diseases or cancer", Lyon, France, november 5th and 6th 2019 - an MS scientist's digest. Kremer D, Weyers V, Gruchot J, Göttle P, Hartung HP, Perron H, Küry P. Mult Scler Relat Disord. 2020 Jul;42:102068. doi: 10.1016/j.msard.2020.102068. Epub 2020 Apr 8. PubMed

  14. Human endogenous retroviruses: ammunition for myeloid cells in neurodegenerative diseases? Gruchot J, Kremer D, Küry P. Neural Regen Res. 2020 Jun;15(6):1043-1044. doi: 10.4103/1673-5374.270311. PubMed

  15. The Molecular Basis for Remyelination Failure in Multiple Sclerosis. Gruchot J, Weyers V, Göttle P, Förster M, Hartung HP, Küry P, Kremer D. Cells. 2019 Aug 3;8(8):825. doi: 10.3390/cells8080825. PubMed

  16. Neural Cell Responses Upon Exposure to Human Endogenous Retroviruses. Gruchot J, Kremer D, Küry P. Front Genet. 2019 Jul 11;10:655. doi: 10.3389/fgene.2019.00655. eCollection 2019. PubMed

  17. pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis. Kremer D, Gruchot J, Weyers V, Oldemeier L, Göttle P, Healy L, Ho Jang J, Kang T Xu Y, Volsko C, Dutta R, Trapp BD, Perron H, Hartung HP, Küry P. Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):15216-15225. doi: 10.1073/pnas.1901283116. Epub 2019 Jun 18. PubMed

  18. Rescuing the negative impact of human endogenous retrovirus envelope protein on oligodendroglial differentiation and myelination. Göttle P, Förster M, Gruchot J, Kremer D, Hartung HP, Perron H, Küry P. Glia. 2019 Jan;67(1):160-170. doi: 10.1002/glia.23535. Epub 2018 Nov 14. PubMed

Graduated 29.06.2016

PhD Thesis
Modeling behavioral and neuropathological phenotypes of brain diseases using in utero electroporation.

Supervisors

Publications

  1. Behavioral Resilience and Sensitivity to Locally Restricted Cortical Migration Deficits Induced by In Utero Knockdown of Disabled-1 in the Adult rat. Sandra Vomund, Maria Angelica de Souza Silva, Joseph P. Huston and Carsten Korth. Cereb Cortex. 2017 Mar 1;27(3):2052-2063. doi: 10.1093/cercor/bhw060. PubMed

  2. Generation of topically transgenic rats by in utero electroporation and in vivo bioluminescence screening. Sandra Vomund, Tamar Sapir, Orly Reiner, Maria Angelica de Souza Siva and Carsten Korth. J. Vis. Exp. (79), e50146, doi:10.3791/50146 (2013) PubMed

  3. Rational design of a minimal and highly enriched CYP102A1 mutant library with improved regio-, stereo- and chemoselectivity. Seifert A, Vomund S, Grohmann K, Kriening S, Urlacher VB, Laschat S, Pleiss J.Chembiochem. 2009 Mar 23;10(5):853-61. Erratum in: Chembiochem. 2009 Jun 15;10(9):1426 PubMed

Graduated 29.06.2016

PhD Thesis
Establishment of a hiPSC-based in vitro model to study environmental and genetic disturbances of neurodevelopmental processes.

Supervisors

Publications

  1. Rabbit neurospheres as a novel in vitro tool for studying neurodevelopmental effects induced by intrauterine growth restriction. Marta Barenys, Miriam Illa, Maxi Hofrichter, Carla Loreiro, Laura Pla, Jördis Klose, Britta Anna Kühne, Jesús Gómez-Catalán, Jan Matthias Braun, Fatima Crispi, Eduard Gratacós, Ellen Fritsche. Stem Cells Transl Med. 2021 Feb;10(2):209-221. doi: 10.1002/sctm.20-0223. Epub 2020 Oct 9. PubMed

  2. Comparative performance analysis of human iPSC-derived and primary neural progenitor cells (NPC) grown as neurospheres in vitro. Maxi Hofrichter, Laura Nimtz, Julia Tigges, Yaschar Kabiri, Friederike Schröter, Brigitte Royer-Pokora, Barbara Hildebrandt, Martin Schmuck, Alexey Epanchintsev, Stephan Theiss, James Adjaye, Jean-Marc Egly, Jean Krutmann, Ellen Fritsche. Stem Cell Res. 2017 Dec;25:72-82. doi: 10.1016/j.scr.2017.10.013. Epub 2017 Oct 26. PubMed

  3. Dual roles of the adenosine A2a receptor in autoimmune neuroinflammation. Ingwersen J, Wingerath B, Graf J, Lepka K, Hofrichter M, Schröter F, Wedekind F, Bauer A, Schrader J, Hartung HP, Prozorovski T, Aktas O. J Neuroinflammation. 2016 Feb 26;13(1):48. doi: 10.1186/s12974-016-0512-z. PubMed

Graduated 30.10.2014

PhD thesis
Sodium dynamics in neurons and astrocytes under epileptiform conditions.

Supervisors

Publications

  1. Lactate rescues neuronal sodium homeostasis during impaired energy metabolism. Karus C, Ziemens D, Rose CR. Channels (Austin). 2015;9(4):200-8. doi: 10.1080/19336950.2015.1050163. Epub 2015 Jun 3. PubMed

  2. Astrocytes restrict discharge duration and neuronal sodium loads during recurrent network activity. Karus C, Mondragão MA, Ziemens D, Rose CR. Glia. 2015 Jun;63(6):936-57. doi: 10.1002/glia.22793. Epub 2015 Jan 29. PubMed

  3. Two sides of the same coin: sodium homeostasis and signaling in astrocytes under physiological and pathophysiological conditions. Rose CR, Karus C. (2013) Glia. 2013 Aug;61(8):1191-205. doi: 10.1002/glia.22492. Epub 2013 Apr 2. PubMed

Graduated November 2016

PhD thesis
Generation and investigation of a faithful model for familial Alzheimer´s disease with presenilin mutations.

Supervisors

Publication

  1. Pathogenic Aβ production by heterozygous PSEN1 mutations is intrinsic to the mutant protein and not mediated by conformational hindrance of wild type PSEN1. Vanessa Kurth, Isabella Ogorek, Carolina Münch, Javier Lopez-Rios, Solenne Ousson, Sandra Lehmann, Katja Nieweg, Anton J M Roebroek, Claus U Pietrzik, Dirk Beher, Sascha Weggen. J Biol Chem. 2023 Aug;299(8):104997. doi: 10.1016/j.jbc.2023.104997. Epub 2023 Jun 30. PubMed

Graduated 07.02.2017

PhD Thesis
Iron-sulfur cluster coordinating Glutaredoxins in neuroinflammatory degeneration and regeneration.

Supervisors

Publications

  1. Glutaredoxin 2 promotes SP-1-dependent CSPG4 transcription and migration of wound healing NG2 glia and glioma cells: Enzymatic Taoism. Christina Wilms, Klaudia Lepka, Felix Häberlein, Steven Edwards, Jörg Felsberg, Linda Pudelko, Tobias T Lindenberg, Gereon Poschmann, Nan Qin, Katrin Volbracht, Tim Prozorovski, Sven G Meuth, Ulf D Kahlert, Marc Remke, Orhan Aktas, Guido Reifenberger, Lars Bräutigam, Benjamin Odermatt, Carsten Berndt. Redox Biol. 2022 Feb;49:102221. doi: 10.1016/j.redox.2021.102221.Epub 2021 Dec 21. PubMed

  2. The metalloprotease ADAMTS4 generates N-truncated Aβ4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease. Susanne Walter, Thorsten Jumpertz, Melanie Hüttenrauch, Isabella Ogorek, Hermeto Gerber, Steffen E Storck, Silvia Zampar, Mitko Dimitrov, Sandra Lehmann, Klaudia Lepka, Carsten Berndt, Jens Wiltfang, Christoph Becker-Pauly, Dirk Beher, Claus U Pietrzik, Patrick C Fraering, Oliver Wirths Sascha Weggen. Acta Neuropathol. 2019 Feb;137(2):239-257. doi: 10.1007/s00401-018-1929-5. Epub 2018 Nov 13 PubMed

  3. Iron-sulfur glutaredoxin 2 protects oligodendrocytes against damage induced by nitric oxide release from activated microglia. Lepka K, Volbracht K, Bill E, Schneider R, Rios N, Hildebrandt T, Ingwersen J, Prozorovski T, Lillig CH, van Horssen J, Steinman L, Hartung HP, Radi R, Holmgren A, Aktas O, Berndt C. Glia. 2017 Sep;65(9):1521-1534. doi: 10.1002/glia.23178. Epub 2017 Jun 15. PubMed

  4. Redox Events As Modulators of Pathology and Therapy of Neuroinflammatory Diseases. Lepka K, Berndt C, Hartung HP, Aktas O. Front Cell Dev Biol. 2016 Jun 23;4:63. doi: 10.3389/fcell.2016.00063. eCollection 2016. PubMed

  5. Dual roles of the adenosine A2a receptor in autoimmune neuroinflammation. Ingwersen J, Wingerath B, Graf J, Lepka K, Hofrichter M, Schröter F, Wedekind F, Bauer A, Schrader J, Hartung HP, Prozorovski T, Aktas O. J Neuroinflammation. 2016 Feb 26;13(1):48. doi: 10.1186/s12974-016-0512-z. PubMed

  6. Redox regulation of cytoskeletal dynamics during differentiation and de-differentiation. Gellert M, Hanschmann EM, Lepka K, Berndt C, Lillig CH. Biochim Biophys Acta. 2015 Aug;1850(8):1575-87. doi: 10.1016/j.bbagen.2014.10.030. Epub 2014 Nov 8. PubMed

  7. Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1. Bräutigam L, Jensen LD, Poschmann G, Nyström S, Bannenberg S, Dreij K, Lepka K, Prozorovski T, Montano SJ, Aktas O, Uhlén P, Stühler K, Cao Y, Holmgren A, Berndt C. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20057-62. doi: 10.1073/pnas.1313753110. Epub 2013 Nov 25. PubMed

Graduated 23.02.2021

PhD Thesis
Chronic effects of environmental pollutants in the nematode Caenorhabditis elegans: Signaling pathways, aging processes and neurodegeneration.

Supervisors

Publications

  1. Silica Nanoparticles Disclose a Detailed Neurodegeneration Profile throughout the Life Span of a Model Organism. Annette Limke, Gereon Poschmann, Kai Stühler, Patrick Petzsch, Thorsten Wachtmeister, Anna von Mikecz. J Xenobiot. 2024 Jan 12;14(1):135-153. doi: 10.3390/jox14010008. PubMed

  2. A Multisystemic Approach Revealed Aminated Polystyrene Nanoparticles-Induced Neurotoxicity. Laura Schröter, Lena Jentsch, Silvia Maglioni, Amanda Muñoz-Juan, Tina Wahle, Annette Limke, Anna von Mikecz, Anna Laromaine, Natascia Ventura. Small. 2023 Oct 29:e2302907. doi: 10.1002/smll.202302907. Online ahead of print. PubMed

  3. Tire components, age and temperature accelerate neurodegeneration in C. elegans models of Alzheimer's and Parkinson's disease. Annette Limke, Inge Scharpf, Fabienne Blesing, Anna von Mikecz. Environ Pollut. 2023 Jul 1;328:121660. doi: 10.1016/j.envpol.2023.121660. Epub 2023 Apr 18. PubMed

  4. Pollutants corrupt resilience pathways of aging in the nematode C. elegans. Andrea Scharf, Annette Limke, Karl-Heinz Guehrs, Anna von Mikecz. iScience. 2022 Aug 28;25(9):105027. doi: 10.1016/j.isci.2022.105027. eCollection 2022 Sep 16. PubMed

  5. The Nucleus of Intestinal Cells of the Bacterivore Nematode Caenorhabditis elegans as a Sensitive Sensor of Environmental Pollutants. Annette Piechulek, Lutz Berwanger, Peter Hemmerich, Anna von Mikecz. Methods Mol Biol. 2020;2175:207-217. doi: 10.1007/978-1-0716-0763-3_15. PubMed

  6. Silica nanoparticles disrupt OPT-2/PEP-2-dependent trafficking of nutrient peptides in the intestinal epithelium. Piechulek A, Berwanger LC, von Mikecz A. Nanotoxicology. 2019 Oct;13(8):1133-1148. doi: 10.1080/17435390.2019.1643048. Epub 2019 Aug 9. PMID: 31340706 PubMed

  7. Aging by pollutants: introducing the aging dose (AD)50. Piechulek, A. & von Mikecz, A. Environ Sci Eur 31, 23 (2019). Springer

  8. Life span-resolved nanotoxicology enables identification of age-associated neuromuscular vulnerabilities in the nematode Caenorhabditis elegans. Piechulek A, von Mikecz A. Environ Pollut. 2018 Feb;233:1095-1103. doi: 10.1016/j.envpol.2017.10.012. Epub 2017 Oct 12. PMID: 29031405 PubMed

  9. Effect of nanoparticles on the biochemical and behavioral aging phenotype of the nematode Caenorhabditis elegans. Scharf A, Piechulek A, von Mikecz A. ACS Nano. 2013 Dec 23;7(12):10695-703. doi: 10.1021/nn403443r. Epub 2013 Nov 23. PMID: 24256469  PubMed

Graduated 15.07.2021

PhD thesis
High-Throuput screening for pharmacological compounds promoting p57kip2 nuclear shuttling and myelin repair.

Supervisors

Publications

  1. Small molecule screening as an approach to encounter inefficient myelin repair. Anastasia Manousi Patrick Küry. Curr Opin Pharmacol. 2021 Dec;61:127-135. doi: 10.1016/j.coph.2021.09.008. Epub 2021 Nov 6. PubMed

  2. C21orf91 Regulates Oligodendroglial Precursor Cell Fate-A Switch in the Glial Lineage? Laura Reiche, Peter Göttle, Lydie Lane, Paula Duek, Mina Park, Kasum Azim, Jana Schütte, Anastasia Manousi, Jessica Schira-Heinen, Patrick Küry. Front Cell Neurosci. 2021 Mar 16;15:653075. doi: 10.3389/fncel.2021.653075. eCollection 2021. PubMed

  3. Identification of novel myelin repair drugs by modulation of oligodendroglial differentiation competence. Anastasia Manousi, Peter Göttle, Laura Reiche, Qiao-Ling Cui, Luke M Healy, Rainer Akkermann, Joel Gruchot, Jessica Schira-Heinen, Jack P Antel, Hans-Peter Hartung, Patrick Küry. EBioMedicine. 2021 Mar;65:103276. doi: 10.1016/j.ebiom.2021.103276. Epub 2021 Mar 10. PubMed

  4. Heterogeneous fate choice of genetically modulated adult neural stem cells in gray and white matter of the central nervous system. Beyer F, Jadasz J, Samper Agrelo I, Schira-Heinen J, Groh J, Manousi A, Bütermann C, Estrada V, Reiche L, Cantone M, Vera J, Viganò F, Dimou L, Müller HW, Hartung HP, Küry P. Glia. 2020 Feb;68(2):393-406. doi: 10.1002/glia.23724. Epub 2019 Oct 21. PubMed

  5. Teriflunomide promotes oligodendroglial differentiation and myelination. Göttle P, Manousi A, Kremer D, Reiche L, Hartung HP, Küry P. J Neuroinflammation. 2018 Mar 13;15(1):76. doi: 10.1186/s12974-018-1110-z. PubMed

Graduated 12.09.2019

PhD Thesis
Protein missassembly in chronic mental illnesses.

Supervisor

Publications

  1. TRIOBP-1 Protein Aggregation Exists in Both Major Depressive Disorder and Schizophrenia, and Can Occur through Two Distinct Regions of the Protein. Beti Zaharija, Maja Odorčić, Anja Hart, Bobana Samardžija, Rita Marreiros, Ingrid Prikulis, Maja Juković, Thomas M Hyde, Joel E Kleinman, Carsten Korth, Nicholas J Bradshaw. Int J Mol Sci. 2022 Sep 21;23(19):11048. doi: 10.3390/ijms231911048. PubMed

  2. Disruption of cellular proteostasis by H1N1 influenza A virus causes α-synuclein aggregation. Rita Marreiros, Andreas Müller-Schiffmann, Svenja V Trossbach, Ingrid Prikulis , Sebastian Hänsch, Stefanie Weidtkamp-Peters, Ana Raquel Moreira, Shriya Sahu, Irina Soloviev, Suganya Selvarajah, Vishwanath R Lingappa, Carsten Korth. Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6741-6751. doi: 10.1073/pnas.1906466117. Epub 2020 Mar 9. PubMed

  3. Biophysical insights from a single chain camelid antibody directed against the Disrupted-in-Schizophrenia 1 protein. Antony S K Yerabham  1 , Andreas Müller-Schiffmann  1 , Tamar Ziehm  2 , Andreas Stadler, Sabrina Köber, Xela Indurkhya, Rita Marreiros, Svenja V Trossbac, Nicholas J Bradshaw, Ingrid Prikulis, Dieter Willbold, Oliver H Weiergräber, Carsten Korth. PLoS One. 2018 Jan 11;13(1):e0191162. doi: 10.1371/journal.pone.0191162. eCollection 2018. PubMed

  4. An unpredicted aggregation-critical region of the actin-polymerizing protein TRIOBP-1/Tara, determined by elucidation of its domain structure. Nicholas J Bradshaw, Antony S K Yerabham, Rita Marreiros, Tao Zhang, Luitgard Nagel-Steger, Carsten Korth. J Biol Chem. 2017 Jun 9;292(23):9583-9598.doi: 10.1074/jbc.M116.767939. Epub 2017 Apr 24. PubMed

  5. Revisiting rodent models: Octodon degus as Alzheimer's disease model? Johannes Steffen, Markus Krohn, Kristin Paarmann, Christina Schwitlick, Thomas Brüning, Rita Marreiros, Andreas Müller-Schiffmann, Carsten Korth, Katharina Braun, Jens Pahnke. Acta Neuropathol Commun. 2016 Aug 26;4(1):91. doi: 10.1186/s40478-016-0363-y. PubMed

  6. Viral capsid assembly as a model for protein aggregation diseases: Active processes catalyzed by cellular assembly machines comprising novel drug targets. Rita Marreiros, Andreas Müller-Schiffmann, Verian Bader, Suganya Selvarajah, Debendranath Dey, Vishwanath R Lingappa, Carsten Korth. Virus Res. 2015 Sep 2;207:155-64. doi: 10.1016/j.virusres.2014.10.003. Epub 2014 Oct 25. PubMed

Graduated 10.03.2021

PhD thesis
Modelling neurological diseases using patientderived induced pluripotent stem cells.

Supervisors

Publications

  1. A call for consensus guidelines on monitoring the integrity of nuclear and mitochondrial genomes in human pluripotent stem cells. Andrea Rossi, Selene Lickfett, Soraia Martins, Alessandro Prigione. Stem Cell Reports. 2022 Apr 12;17(4):707-710.doi: 10.1016/j.stemcr.2022.01.019. Epub 2022 Mar 3. PubMed
  2. Impaired p53-Mediated DNA Damage Response Contributes to Microcephaly in Nijmegen Breakage Syndrome Patient-Derived Cerebral Organoids. Soraia Martins, Lars Erichsen, Angeliki Datsi, Wasco Wruck, Wolfgang Goering, Eleftheria Chatzantonaki, Vanessa Cristina Meira de Amorim, Andrea Rossi, Krystyna H Chrzanowska, James Adjaye. Cells. 2022 Feb 25;11(5):802. doi: 10.3390/cells11050802. PubMed
  3. Generation of a Crigler-Najjar Syndrome Type I patient-derived induced pluripotent stem cell line CNS705 (HHUUKDi005-A). Nina Graffmann, Soraia Martins, Tijana Ljubikj, Julie Carole Matte, Martina Bohndorf, Wasco Wruck, James Adjaye. Stem Cell Res. 2021 Mar;51:102167.doi: 10.1016/j.scr.2021.102167. Epub 2021 Jan 12. PubMed
  4. A stem cell based in vitro model of NAFLD enables the analysis of patient specific individual metabolic adaptations in response to a high fat diet and AdipoRon interference.  Nina Graffmann, Audrey Ncube, Soraia Martins, Aurelian Robert Fiszl, Philipp Reuther, Martina Bohndorf, Wasco Wruck, Mathias Beller, Constantin Czekelius, James Adjaye. Biol Open. 2021 Jan 25;10(1):bio054189.doi: 10.1242/bio.054189. PubMed
  5. Matrix Metalloproteinase 14 Mediates APP Proteolysis and Lysosomal Alterations Induced by Oxidative Stress in Human Neuronal Cells. Patricia Llorente, Soraia Martins, Isabel Sastre, Jesús Aldudo, María Recuero, James Adjaye, Maria J Bullido. Oxid Med Cell Longev. 2020 Nov 16;2020:5917187. doi: 10.1155/2020/5917187. eCollection 2020. PubMed
  6. IPSC-Derived Neuronal Cultures Carrying the Alzheimer's Disease Associated TREM2 R47H Variant Enables the Construction of an Aβ-Induced Gene Regulatory Network. Soraia Martins, Andreas Müller-Schiffmann, Lars Erichsen, Martina Bohndorf, Wasco Wruck, Kristel Sleegers, Christine Van Broeckhoven, Carsten Korth, James Adjaye. Int J Mol Sci. 2020 Jun 25;21(12):4516. doi: 10.3390/ijms21124516. PubMed
  7. AP-2 reduces amyloidogenesis by promoting BACE1 trafficking and degradation in neurons. Sujoy Bera, Santiago Camblor-Perujo, Elena Calleja Barca, Albert Negrete-Hurtado, Julia Racho, Elodie De Bruyckere, Christoph Wittich  , Nina Ellrich, Soraia Martins, James Adjaye, Natalia L Kononenko. EMBO Rep. 2020 Jun 4;21(6):e47954. doi: 10.15252/embr.201947954. Epub 2020 Apr 23. PubMed
  8. The FGF, TGFβ and WNT axis Modulate Self-renewal of Human SIX2 + Urine Derived Renal Progenitor Cells. Md Shaifur Rahman, Wasco Wruck, Lucas-Sebastian Spitzhorn, Lisa Nguyen, Martina Bohndorf, Soraia Martins, Fatima Asar, Audrey Ncube, Lars Erichsen, Nina Graffmann, James Adjaye. Sci Rep. 2020 Jan 20;10(1):739. doi: 10.1038/s41598-020-57723-2. PubMed
  9. Lymphoblast-derived integration-free iPSC line AD-TREM2-3 from a 74 year-old Alzheimer's disease patient expressing the TREM2 p.R47H variant. Soraia Martins, Hatice Yigit, Martina Bohndorf, Nina Graffmann, Aurelian Robert Fiszl, Wasco Wruck, Kristel Sleegers, Christine Van Broeckhoven, James Adjaye. Stem Cell Res. 2018 Jul;30:141-144. doi: 10.1016/j.scr.2018.05.018. Epub 2018 Jun 1. PubMed
  10. Lymphoblast-derived integration-free iPSC line AD-TREM2-1 from a 67year-old Alzheimer's disease patient expressing the TREM2 p.R47H variant. Soraia Martins, Hatice Yigit, Martina Bohndorf, Nina Graffmann, Aurelian Robert Fiszl, Wasco Wruck, Kristel Sleegers, Christine Van Broeckhoven, James Adjaye. Stem Cell Re. 2018 May;29:60-63. doi: 10.1016/j.scr.2018.03.011. Epub 2018 Mar 20. PubMed
  11. Lymphoblast-derived integration-free ISRM-CON9 iPS cell line from a 75year old female. Soraia Martins, Martina Bohndorf, Friederike Schröter, Fatima Assar, Wasco Wruck, Kristel Sleegers, Christine Van Broeckhoven, James Adjaye. Stem Cell Res. 2018 Jan;26:76-79. doi: 10.1016/j.scr.2017.12.007. Epub 2017 Dec 13. PubMed
  12. Nijmegen Breakage Syndrome fibroblasts and iPSCs: cellular models for uncovering disease-associated signaling pathways and establishing a screening platform for anti-oxidants. Barbara Mlody, Wasco Wruck, Soraia Martins, Karl Sperling, James Adjaye. Sci Rep. 2017 Aug 8;7(1):7516. doi: 10.1038/s41598-017-07905-2. PubMed

Graduated 25.06.2018

PhD thesis
Cell specific analysis of AMPA receptor complexes in development and disease.

Supervisors

Publications

  1. Heterogeneity of the astrocytic AMPA-receptor transcriptome. Mölders A, Koch A, Menke R, Klöcker N. Glia. 2018 Dec;66(12):2604-2616. doi: 10.1002/glia.23514. Epub 2018 Oct 28. PubMed

  2. Depletion of the AMPAR reserve pool impairs synaptic plasticity in a model of hepatic encephalopathy. Schroeter A, Wen S, Mölders A, Erlenhardt N, Stein V, Klöcker N. Mol Cell Neurosci. 2015 Sep;68:331-9. doi: 10.1016/j.mcn.2015.09.001. Epub 2015 Sep 9. PubMed

  3. Ontogeny repeats the phylogenetic recruitment of the cargo exporter cornichon into AMPA receptor signaling complexes. Mauric V, Mölders A, Harmel N, Heimrich B, Sergeeva OA, Klöcker N. (2013) Mol Cell Neurosci. 2013 Sep;56C:10-17. doi: 10.1016/j.mcn.2013.02.001. Epub 2013 Feb 8. Pubmed

Graduated 13.12.2018

PhD thesis
Na+ signaling in white matter glial cells.

Supervisors

Publications

  1. Astrocyte Sodium Signalling and Panglial Spread of Sodium Signals in Brain White Matter. Behrouz Moshrefi-Ravasdjani, Evelyn L Hammel, Karl W Kafitz, Christine R Rose. Neurochem Res. 2017 Sep;42(9):2505-2518. doi: 10.1007/s11064-017-2197-9. Epub 2017 Feb 18. PubMed

  2. Rapid sodium signaling couples glutamate uptake to breakdown of ATP in perivascular astrocyte endfeet. Julia Langer, Niklas J Gerkau, Amin Derouiche, Christian Kleinhans, Behrouz Moshrefi-Ravasdjani, Michaela Fredrich, Karl W Kafitz, Gerald Seifert, Christian Steinhäuser, Christine R Rose. Glia. 2017 Feb;65(2):293-308. doi: 10.1002/glia.23092. Epub 2016 Oct 27. PubMed

  3. Changes in the proliferative capacity of NG2 cell subpopulations during postnatal development of the mouse hippocampus. Behrouz Moshrefi-Ravasdjani, Pavel Dublin, Gerald Seifert, Katja Jennissen, Christian Steinhäuser Karl W Kafitz, Christine R Rose. Brain Struct Funct. 2017 Mar;222(2):831-847. doi: 10.1007/s00429-016-1249-2. Epub 2016 Jun 15. PubMed

Graduated 17.11.2023

PhD Thesis
Effects of energy deprivation on cellular ion homeostasis in the mouse brain.

Supervisors

Publications

  1. Inward Operation of Sodium-Bicarbonate Cotransporter 1 Promotes Astrocytic Na+ Loading and Loss of ATP in Mouse Neocortex during Brief Chemical Ischemia. Katharina Everaerts, Pawan Thapaliya, Nils Pape, Simone Durry, Sara Eitelmann, Eleni Roussa, Ghanim Ullah, Christine R Rose. Cells. 2023 Nov 21;12(23):2675. doi: 10.3390/cells12232675. PubMed
  2. Activation of TRPV4 channels promotes the loss of cellular ATP in organotypic slices of the mouse neocortex exposed to chemical ischemia. Nils Pape, Christine R Rose. 2023 Jul;601(14):2975-2990.doi: 10.1113/JP284430. Epub 2023 Jun 6. PubMed
  3. Modeling the heterogeneity of sodium and calcium homeostasis between cortical and hippocampal astrocytes and its impact on bioenergetics. Pawan Thapaliya, Nils Pape, Christine R Rose, Ghanim Ullah. Front Cell Neurosci. 2023 Jan 30;17:1035553. doi: 10.3389/fncel.2023.1035553. eCollection 2023. PubMed
  4. Changes in Astroglial K + upon Brief Periods of Energy Deprivation in the Mouse Neocortex. Sara Eitelmann, Jonathan Stephan, Katharina Everaerts, Simone Durry, Nils Pape, Niklas J Gerkau, Christine R Rose. Int J Mol Sci. 2022 Apr 27;23(9):4836. doi: 10.3390/ijms23094836. PubMed

Graduated 19.09.2015

PhD Thesis
Neurochemical mechanisms of motoric, cognitive and affective functions in the hemiparkinsonian rat model.

Supervisors

Publications

  1. Rats bred for helplessness exhibit positive reinforcement learning deficits which are not alleviated by an antidepressant dose of the MAO-B inhibitor deprenyl. Schulz D, Henn FA, Petri D, Huston JP. Neuroscience. 2016 Aug 4;329:83-92. doi: 10.1016/j.neuroscience.2016.04.049. Epub 2016 May 6. PubMed

  2. Evidence for a Specific Integrative Mechanism for Episodic Memory Mediated by AMPA/kainate Receptors in a Circuit Involving Medial Prefrontal Cortex and Hippocampal CA3 Region. de Souza Silva MA, Huston JP, Wang AL, Petri D, Chao OY. Cereb Cortex. 2016 Jul;26(7):3000-9. doi: 10.1093/cercor/bhv112. Epub 2015 Jun 5. PubMed

  3. Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans. Trenado C, Elben S, Petri D, Hirschmann J, Groiss SJ, Vesper J, Schnitzler A, Wojtecki L. J Vis Exp. 2016 May 19;(111). doi: 10.3791/53466. PubMed

  4. Serotonergic interaction between medial prefrontal cortex and mesotelencephalic DA system underlies cognitive and affective deficits in hemiparkinsonian rats. Petri D, de Souza Silva MA, Chao OY, Schnitzler A, Huston JP. Neuroscience. 2015 Oct 29;307:51-63. doi: 10.1016/j.neuroscience.2015.08.022. Epub 2015 Aug 24. PubMed

  5. Dopamine in the nucleus accumbens core, but not shell, increases during signaled food reward and decreases during delayed extinction. Biesdorf C, Wang AL, Topic B, Petri D, Milani H, Huston JP, de Souza Silva MA. 2015 Sep;123:125-39. doi: 10.1016/j.nlm.2015.06.002. Epub 2015 Jun 10. PubMed

  6. Modulation of central thalamic oscillations during emotional-cognitive processing in chronic disorder of consciousness. Wojtecki L, Petri D, Elben S, Hirschmann J, Yelnik J, Eickhoff S, Vesper J, Schnitzler A. (2014) Cortex. 2014 Nov;60:94-102. PubMed

  7. GABAA-receptor activation in the subthalamic nucleus compensates behavioral asymmetries in the hemiparkinsonian rat. Petri D, Pum M, Vesper J, Huston JP, Schnitzler A. (2013) Behav Brain Res. 2013 Sep 1;252:58-67. doi: 10.1016/j.bbr.2013.05.044. Epub 2013 May 30. PubMed

Graduated 28.05.2021

PhD thesis
Identification of mesenchymal stem cell-derived factors with prooligodendrogenic activities.

Supervisors

Publications

  1. Teriflunomide as a therapeutic means for myelin repair. Peter Göttle, Janos Groh, Laura Reiche, Joel Gruchot, Nicole Rychlik, Luisa Werner, Iria Samper Agrelo, Rainer Akkermann, Annika Zink, Alessandro Prigione, Hans-Peter Hartung, Rudolf Martini, Patrick Küry. J Neuroinflammation. 2023 Jan 7;20(1):7. doi: 10.1186/s12974-022-02686-6. PubMed
  2. Functional in vivo assessment of stem cell-secreted pro-oligodendroglial factors. Jessica Schira-Heinen, Iria Samper Agrelo, Veronica Estrada, Patrick Küry. Neural Regen Res. 2022 Oct;17(10):2194-2196. doi: 10.4103/1673-5374.335800. PubMed
  3. Secretome Analysis of Mesenchymal Stem Cell Factors Fostering Oligodendroglial Differentiation of Neural Stem Cells In Vivo. Iria Samper Agrelo, Jessica Schira-Heinen, Felix Beyer, Janos Groh, Christine Bütermann, Veronica Estrada, Gereon Poschmann, Ana Bribian, Janusz J Jadasz, Laura Lopez-Mascaraque, David Kremer, Rudolf Martini, Hans Werner Müller, Hans Peter Hartung, James Adjaye, Kai Stühler, Patrick Küry. Int J Mol Sci. 2020 Jun 18;21(12):E4350.doi: 10.3390/ijms21124350. PubMed
  4. Heterogeneous fate choice of genetically modulated adult neural stem cells in gray and white matter of the central nervous system. Beyer F, Jadasz J, Samper Agrelo I, Schira-Heinen J, Groh J, Manousi A, Bütermann C, Estrada V, Reiche L, Cantone M, Vera J, Viganò F, Dimou L, Müller HW, Hartung HP, Küry P. Glia. 2020 Feb;68(2):393-406. doi: 10.1002/glia.23724. Epub 2019 Oct 21. PubMed
  5. Do Neural Stem Cells Have a Choice? Heterogenic Outcome of Cell Fate Acquisition in Different Injury Models. Beyer F, Samper Agrelo I, Küry P. Int J Mol Sci. 2019 Jan 21;20(2). pii: E455. doi: 10.3390/ijms20020455. PubMed
  6. Human mesenchymal factors induce rat hippocampal- and human neural stem cell dependent oligodendrogenesis. Jadasz JJ, Tepe L, Beyer F, Samper Agrelo I, Akkermann R, Spitzhorn LS, Silva ME, Oreffo ROC, Hartung HP, Prigione A, Rivera FJ, Adjaye J, Küry P. Glia. 2018 Jan;66(1):145-160. doi: 10.1002/glia.23233. Epub 2017 Sep 22. PubMed

Graduated 18.10.2022

PhD thesis
Investigating the pro myelinating activity of a corticosteroid in a cuprizone dependent chronic demyelination model.

Supervisors

Publications

  1. The laminar position, morphology, and gene expression profiles of cortical astrocytes are influenced by time of birth from ventricular/subventricular progenitors. Daniela Lozano Casasbuenas, Ines Kortebi, Charles Gora, Erica Y Scott, Celeste Gomes, Markley Silva Oliveira Jr, Tanvi Sharma, Emerson Daniele, Arman Olfat, Rachel Gibbs, Scott A Yuzwa, Emily A Gilbert, Patrick Küry, Aaron R Wheeler, Martin Lévesque, Maryam Faiz. Glia. 2024 Jun 9. doi: 10.1002/glia.24578. Online ahead of print. PubMed
  2. Star power: harnessing the reactive astrocyte response to promote remyelination in multiple sclerosis. Markley Silva Oliveira Junior, Laura Reiche, Emerson Daniele, Ines Kortebi, Maryam Faiz, Patrick Küry. Neural Regen Res. 2024 Mar;19(3):578-582. doi: 10.4103/1673-5374.380879. PubMed
  3. A Novel Ex Vivo Model to Study Therapeutic Treatments for Myelin Repair following Ischemic Damage. Luisa Werner, Michael Gliem, Nicole Rychlik, Goran Pavic, Laura Reiche, Frank Kirchhoff, Markley Silva Oliveira Junior, Joel Gruchot, Sven G Meuth, Patrick Küry, Peter Göttle. Int J Mol Sci. 2023 Jun 30;24(13):10972. doi: 10.3390/ijms241310972. PubMed
  4. Myelin repair is fostered by the corticosteroid medrysone specifically acting on astroglial subpopulations. Markley Silva Oliveira Junior, Jessica Schira-Heinen, Laura Reiche, Seulki Han, Vanessa Cristina Meira de Amorim, Isabel Lewen, Joel Gruchot, Peter Göttle, Rainer Akkermann, Kasum Azim, Patrick Küry. EBioMedicine. 2022 Sep;83:104204.doi: 10.1016/j.ebiom.2022.104204. Epub 2022 Aug 8. PubMed

Graduated 13.03.2020

PhD thesis
Experimental studies concerning the unfolded protein response in glioma pathogenesis.

Supervisors

Publications

  1. The long non-coding RNA HOTAIRM1 promotes tumor aggressiveness and radiotherapy resistance in glioblastoma. Ulvi Ahmadov, Daniel Picard, Jasmin Bartl, Manuela Silginer, Marija Trajkovic-Arsic, Nan Qin, Lena Blümel, Marietta Wolter, Jonathan K M Lim, David Pauck, Alina Marie Winkelkotte, Marlen Melcher, Maike Langini, Viktoria Marquardt, Felix Sander, Anja Stefanski, Sascha Steltgens, Christina Hassiepen, Anna Kaufhold, Frauke-Dorothee Meyer, Annette Seibt, Lara Kleinesudeik, Anika Hain , Carsten Münk, Christiane Brigitte Knobbe-Thomsen, Alexander Schramm, Ute Fischer, Gabriel Leprivier, Kai Stühler, Simone Fulda, Jens T Siveke, Felix Distelmaier, Arndt Borkhardt, Michael Weller, Patrick Roth, Guido Reifenberger, Marc Remke. Cell Death Dis. 2021 Sep 28;12(10):885. doi: 10.1038/s41419-021-04146-0. PubMed

  2. A Multi-Omics Analysis Reveals the Unfolded Protein Response Regulon and Stress-Induced Resistance to Folate-Based Antimetabolites. Stefan Reich, Chi D L Nguyen, Canan Has, Sascha Steltgens, Himanshu Soni, Cristina Coman, Moritz Freyberg, Anna Bichler, Nicole Seifert, Dominik Conrad, Christiane B Knobbe-Thomsen, Björn Tews, Grischa Toedt, Robert Ahrends, Jan Medenbach. Nat Commun. 2020 Jun 10;11(1):2936.doi: 10.1038/s41467-020-16747-y. PubMed

  3. A sensitive and simple targeted proteomics approach to quantify transcription factor and membrane proteins of the unfolded protein response pathway in glioblastoma cells. Nguyen CDL, Malchow S, Reich S, Steltgens S, Shuvaev KV, Loroch S, Lorenz C, Sickmann A, Knobbe-Thomsen CB, Tews B, Medenbach J, Ahrends R. Sci Rep. 2019 Jun 20;9(1):8836. doi: 10.1038/s41598-019-45237-5. PubMed

Graduated 15.06.2023

PhD Thesis
Impact of blood platelets in the progression of Alzheimer´s disease.

Supervisors

  • Prof. Dr. Patricia Hidalgo

  • Prof. Dr. Margitta Elvers

Publications

  1. Platelet pannexin-1 channels modulate neutrophil activation and migration but not the progression of abdominal aortic aneurysm. Lisa Maria Metz, Tobias Feige, Larissa de Biasi, Agnes Ehrenberg, Joscha Mulorz, Laura Mara Toska, Friedrich Reusswig, Christine Quast, Norbert Gerdes, Malte Kelm, Hubert Schelzig, Margitta Elvers. Front Mol Biosci. 2023 Mar 6:10:1111108. doi: 10.3389/fmolb.2023.1111108. eCollection 2023. PubMed

  2. Impact of Amyloid-β on Platelet Mitochondrial Function and Platelet-Mediated Amyloid Aggregation in Alzheimer's Disease. Lili Donner, Tobias Feige, Carolin Freiburg, Laura Mara Toska, Andreas S Reichert, Madhumita Chatterjee, Margitta Elvers. Int J Mol Sci. 2021 Sep 6;22(17):9633. doi: 10.3390/ijms22179633. PubMed

  3. Molecular Drivers of Platelet Activation: Unraveling Novel Targets for Anti-Thrombotic and Anti-Thrombo-Inflammatory Therapy. Madhumita Chatterjee, Agnes Ehrenberg, Laura Mara Toska, Lisa Maria Metz, Meike Klier, Irena Kruege, Friedrich Reusswig, Margitta Elvers. Int J Mol Sci. 2020 Oct 24;21(21):E7906. doi: 10.3390/ijms21217906. PubMed

  4. The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of β-amyloid. Lili Donner, Laura Mara Toska, Irena Krüger, Sandra Gröniger, Ruben Barroso, Alice Burleigh, Diego Mezzano, Susanne Pfeiler, Malte Kelm, Norbert Gerdes, Steve P Watson, Yi Sun, Margitta Elvers. Sci Signal. 2020 Aug 4;13(643):eaba9872. doi: 10.1126/scisignal.aba9872. PubMed

 

Graduated 24.05.2019

PhD Thesis
Role of CXCR4 in mediating axon sprouting after local intrathecal infusion of CXCL12 in a mouse model of spinal cord injury.

Supervisors

Graduated 07.07.2022

PhD thesis
Abeta prion spreading: Correlation with behavior and prion protein cofactor.

Supervisor

Publications

  1. Soluble amyloid-β dimers are resistant to amyloid-β prion conversion in vivo suggesting antiprion properties. Else F van Gerresheim, Andreas Müller-Schiffmann, Sandra Schäble, Bastijn Koopmans, Maarten Loos, Carsten Korth. Neuropathol Appl Neurobiol. 2023 Apr;49(2):e12895. doi: 10.1111/nan.12895.   PubMed

  2. The interaction of insoluble Amyloid-β with soluble Amyloid-β dimers decreases Amyloid-β plaque numbers. Else F van Gerresheim, Arne Herring, Lothar Gremer, Andreas Müller-Schiffmann, Kathy Keyvani, Carsten Korth. Neuropathol Appl Neurobiol. 2021 Aug;47(5):603-610. doi: 10.1111/nan.12685. Epub 2021 Jan 7. . PubMed

Graduated 03.2022

PhD thesis
Precision medicine developments against glioblastoma stem cells in a preclinical setting.

Supervisors

Publications

  1. mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism. Tal Levy, Kai Voeltzke, Laura Hruby, Khawla Alasad, Zuelal Bas, Marteinn Snaebjörnsson, Ran Marciano, Katerina Scharov, Mélanie Planque, Kim Vriens, Stefan Christen, Cornelius M Funk, Christina Hassiepen, Alisa Kahler, Beate Heider, Daniel Picard, Jonathan K M Lim, Anja Stefanski, Katja Bendrin, Andres Vargas-Toscano, Ulf D Kahlert, Kai Stühler, Marc Remke, Moshe Elkabets, Thomas G P Grünewald, Andreas S Reichert, Sarah-Maria Fendt, Almut Schulze, Guido Reifenberger, Barak Rotblat, Gabriel Leprivier. Nat Commun. 2024 May 14;15(1):4083. doi: 10.1038/s41467-024-48386-y. PubMed

  2. A Preclinical Pipeline for Translational Precision Medicine-Experiences from a Transdisciplinary Brain Tumor Stem Cell Project. Andres Vargas-Toscano, Christoph Janiak, Michael Sabel, Ulf Dietrich Kahlert. J Pers Med. 2021 Sep 7;11(9):892. doi: 10.3390/jpm11090892.  PubMed

  3. Rapalink-1 Targets Glioblastoma Stem Cells and Acts Synergistically with Tumor Treating Fields to Reduce Resistance against Temozolomide. Andres Vargas-Toscano, Ann-Christin Nickel, Guanzhang Li, Marcel Alexander Kamp, Sajjad Muhammad, Gabriel Leprivier, Ellen Fritsche, Roger A Barker, Michael Sabel, Hans-Jakob Steiger, Wei Zhang, Daniel Hänggi, Ulf Dietrich Kahlert. Cancers (Basel). 2020 Dec 21;12(12):3859. doi: 10.3390/cancers12123859. PubMed

  4. Robot Technology Identifies a Parkinsonian Therapeutics Repurpose to Target Stem Cells of Glioblastoma. Andres Vargas-Toscano, Dilaware Khan, Ann-Christin Nickel, Michael Hewera, Marcel Alexander Kamp, Igor Fischer, Hans-Jakob Steiger, Wei Zhang, Sajjad Muhammad, Daniel Hänggi, Ulf Dietrich Kahlert. CNS Oncol. 2020 Jun;9(2):CNS58. doi: 10.2217/cns-2020-0004. Epub 2020 May 28. PubMed

  5. Influence of synthesis methods on the internalization of fluorescent gold nanoparticles into glioblastoma stem-like cells. Giesen B, Nickel AC, Garzón Manjón A, Vargas Toscano A, Scheu C, Kahlert UD, Janiak C. J Inorg Biochem. 2020 Feb;203:110952. doi: 10.1016/j.jinorgbio.2019.110952. Epub 2019 Nov 23. PMID: 31794896 PubMed

  6. Seizure frequency reduction after posteromedial hypothalamus deep brain stimulation in drug-resistant epilepsy associated with intractable aggressive behavior. Benedetti-Isaac JC, Torres-Zambrano M, Vargas-Toscano A, Perea-Castro E, Alcalá-Cerra G, Furlanetti LL, Reithmeier T, Tierney TS, Anastasopoulos C, Fonoff ET, Contreras Lopez WO. Epilepsia. 2015 Jul;56(7):1152-61. doi: 10.1111/epi.13025. Epub 2015 Jul 4. PMID: 26146753 PubMed

Graduated 23.08.2021

PhD thesis
Redox-dependent differentiation and dedifferentiation.

Supervisors

Publication

  1. Glutaredoxin 2 promotes SP-1-dependent CSPG4 transcription and migration of wound healing NG2 glia and glioma cells: Enzymatic Taoism. Christina Wilms, Klaudia Lepka, Felix Häberlein, Steven Edwards, Jörg Felsberg, Linda Pudelko, Tobias T Lindenberg, Gereon Poschmann, Nan Qin, Katrin Volbracht, Tim Prozorovski, Sven G Meuth, Ulf D Kahlert, Marc Remke, Orhan Aktas, Guido Reifenberger, Lars Bräutigam, Benjamin Odermatt, Carsten Berndt. Redox Biol. 2022 Feb;49:102221. doi: 10.1016/j.redox.2021.102221.Epub 2021 Dec 21. PubMed

Graduated 31.07.2017

PhD thesis
Investigations of the structural organization of the Disrupted-in-Schizophrenia 1 (DISC1) protein, a major risk factor for mental illness.

Supervisor

Publications

  1. Biophysical insights from a single chain camelid antibody directed against the Disrupted-in-Schizophrenia 1 protein. Antony S K Yerabham  1 , Andreas Müller-Schiffmann  1 , Tamar Ziehm  2 , Andreas Stadler, Sabrina Köber, Xela Indurkhya, Rita Marreiros, Svenja V Trossbac, Nicholas J Bradshaw, Ingrid Prikulis, Dieter Willbold, Oliver H Weiergräber, Carsten Korth. PLoS One. 2018 Jan 11;13(1):e0191162. doi: 10.1371/journal.pone.0191162. eCollection 2018. PubMed

  2. An unpredicted aggregation-critical region of the actin-polymerizing protein TRIOBP-1/Tara, determined by elucidation of its domain structure. Nicholas J Bradshaw, Antony S K Yerabham, Rita Marreiros, Tao Zhang, Luitgard Nagel-Steger, Carsten Korth. J Biol Chem. 2017 Jun 9;292(23):9583-9598.doi: 10.1074/jbc.M116.767939. Epub 2017 Apr 24. PubMed

  3. A structural organization for the Disrupted in Schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions, which are bisected by mental illness-related mutations. Antony S K Yerabham, Philippe J Mas, Christina Decker, Dinesh C Soares, Oliver H Weiergräber, Luitgard Nagel-Steger, Dieter Willbold, Darren J Hart, Nicholas J Bradshaw, Carsten Korth. J Biol Chem. 2017 Apr 21;292(16):6468-6477. doi: 10.1074/jbc.M116.773903. Epub 2017 Mar 1. PubMed

  4. Revisiting disrupted-in-schizophrenia 1 as a scaffold protein. Antony S K Yerabham, Oliver H Weiergräber, Nicholas J Bradshaw, Carsten Korth. Biol Chem. 2013 Nov;394(11):1425-37. doi: 10.1515/hsz-2013-0178. PubMed

     

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