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Neurone im Raum mit iBrain Logo

Alumni

Graduated 19.06.2019

PhD thesis
Regulation of myelination in the developing and regenerating CNS.

Supervisors

Publications

  1. Protective effects of 4-aminopyridine in experimental optic neuritis and multiple sclerosis. Michael Dietrich, Valeria Koska, Christina Hecker, Peter Göttle, Alexander M Hilla, Annemarie Heskamp, Klaudia Lepka, Andrea Issberner, Angelika Hallenberger, Christine Baksmeier, Julia Steckel, Lisanne Balk, Benjamin Knier, Thomas Korn, Joachim Havla, Elena H Martínez-Lapiscina, Nuria Solà-Valls, Praveena Manogaran, Elisabeth D Olbert, Sven Schippling, Andrés Cruz-Herranz, Hao Yiu, Julia Button, Natalia Gonzalez Caldito, Charlotte von Gall, Anne K Mausberg, Mark Stettner, Hannah G Zimmermann, Friedemann Paul, Alexander U Brandt, Patrick Küry, Norbert Goebels, Orhan Aktas, Carsten Berndt, Shiv Saidha, Ari J Green, Peter A Calabresi, Dietmar Fischer, Hans-Peter Hartung, Philipp Albrecht. Brain. 2020 Apr 1;143(4):1127-1142. doi: 10.1093/brain/awaa062. PubMed

  2. NMDAR encephalitis: passive transfer from man to mouse by a recombinant antibody. Malviya M, Barman S, Golombeck KS, Planagumà J, Mannara F, Strutz-Seebohm N, Wrzos C, Demir F, Baksmeier C, Steckel J, Falk KK, Gross CC, Kovac S, Bönte K, Johnen A, Wandinger KP, Martín-García E, Becker AJ, Elger CE, Klöcker N, Wiendl H, Meuth SG, Hartung HP, Seebohm G, Leypoldt F, Maldonado R, Stadelmann C, Dalmau J, Melzer N, Goebels N. Ann Clin Transl Neurol. 2017 Oct 3;4(11):768-783. doi: 10.1002/acn3.444. eCollection 2017 Nov. PubMed
  3. Epigallocatechin gallate (EGCG) inhibits adhesion and migration of neural progenitor cells in vitro. Barenys M, Gassmann K, Baksmeier C, Heinz S, Reverte I, Schmuck M, Temme T, Bendt F, Zschauer TC, Rockel TD, Unfried K, Wätjen W, Sundaram SM, Heuer H, Colomina MT, Fritsche E. Arch Toxicol. 2017 Feb;91(2):827-837. doi: 10.1007/s00204-016-1709-8. Epub 2016 Apr 26. PubMed
  4. Dose-dependent inhibition of demyelination and microglia activation by IVIG. Winter M, Baksmeier C, Steckel J, Barman S, Malviya M, Harrer-Kuster M, Hartung HP, Goebels N. Ann Clin Transl Neurol. 2016 Sep 23;3(11):828-843. eCollection 2016. PubMed

Graduated 25.02.2021

PhD thesis
Heterogeneous fate choice of neural stem cells in the damaged and intact central nervous system.

Supervisors

Publications

  1. Secretome Analysis of Mesenchymal Stem Cell Factors Fostering Oligodendroglial Differentiation of Neural Stem Cells In Vivo. Iria Samper Agrelo, Jessica Schira-Heinen, Felix Beyer, Janos Groh, Christine Bütermann, Veronica Estrada, Gereon Poschmann, Ana Bribian, Janusz J Jadasz, Laura Lopez-Mascaraque, David Kremer, Rudolf Martini, Hans Werner Müller, Hans Peter Hartung, James Adjaye, Kai Stühler, Patrick Küry. Int J Mol Sci. 2020 Jun 18;21(12):E4350.doi: 10.3390/ijms21124350. PubMed
  2. Imaging of Intracellular ATP in Organotypic Tissue Slices of the Mouse Brain using the FRET-based Sensor ATeam1.03YEMK. Rodrigo Lerchundi, Karl W Kafitz, Marcel Färfers, Felix Beyer, Na Huang, Christine R Rose. J Vis Exp. 2019 Dec 19;(154). doi: 10.3791/60294. PubMed
  3. Heterogeneous fate choice of genetically modulated adult neural stem cells in gray and white matter of the central nervous system. Beyer F, Jadasz J, Samper Agrelo I, Schira-Heinen J, Groh J, Manousi A, Bütermann C, Estrada V, Reiche L, Cantone M, Vera J, Viganò F, Dimou L, Müller HW, Hartung HP, Küry P. Glia. 2020 Feb;68(2):393-406. doi: 10.1002/glia.23724. Epub 2019 Oct 21. PubMed
  4. A gene regulatory architecture that controls region-independent dynamics of oligodendrocyte differentiation. Martina Cantone, Melanie Küspert, Simone Reiprich, Xin Lai, Martin Eberhardt, Peter Göttle, Felix Beyer, Kasum Azim, Patrick Küry , Michael Wegner Julio Vera. Glia. 2019 May;67(5):825-843. doi: 10.1002/glia.23569. Epub 2019 Feb 7. PubMed
  5. Do Neural Stem Cells Have a Choice? Heterogenic Outcome of Cell Fate Acquisition in Different Injury Models. Beyer F, Samper Agrelo I, Küry P. Int J Mol Sci. 2019 Jan 21;20(2). pii: E455. doi: 10.3390/ijms20020455. PubMed
  6. Human mesenchymal factors induce rat hippocampal- and human neural stem cell dependent oligodendrogenesis. Jadasz JJ, Tepe L, Beyer F, Samper Agrelo I, Akkermann R, Spitzhorn LS, Silva ME, Oreffo ROC, Hartung HP, Prigione A, Rivera FJ, Adjaye J, Küry P. Glia. 2018 Jan;66(1):145-160. doi: 10.1002/glia.23233. Epub 2017 Sep 22. PubMed
  7. Heterogeneous populations of neural stem cells contribute to myelin repair. Rainer Akkermann, Felix Beyer, Patrick Küry. Neural Regen Res. 2017 Apr;12(4):509-517. doi: 10.4103/1673-5374.204999. PubMed
  8. Novel approaches for the development of peripheral nerve regenerative therapies. Felix Beyer, Patrick Küry. Neural Regen Res. 2015 Nov;10(11):1743-5. doi: 10.4103/1673-5374.170298. PubMed
  9. Fingolimod induces the transition to a nerve regeneration promoting Schwann cell phenotype. Heinen A, Beyer F, Tzekova N, Hartung HP, Küry P. Exp Neurol. 2015 Sep;271:25-35. doi: 10.1016/j.expneurol.2015.05.002. Epub 2015 May 7. PubMed
  10. Intrinsically active and pacemaker neurons in pluripotent stem cell-derived neuronal populations. Illes S, Jakab M, Beyer F, Gelfert R, Couillard-Despres S, Schnitzler A, Ritter M, Aigner L. Stem Cell Reports. 2014 Feb 20;2(3):323-36. doi: 10.1016/j.stemcr.2014.01.006. eCollection 2014 Mar 11. PubMed

Graduated 29.01.2020

PhD thesis
Role of adhesion molecules in synapse formation, function and plasticity.

Supervisors

Publications

  1. Differential Properties of the Synaptogenic Activities of the Neurexin Ligands Neuroligin1 and LRRTM2. Sushma Dagar, Kurt Gottmann. Front Mol Neurosci. 2019 Nov 8;12:269. doi: 10.3389/fnmol.2019.00269. eCollection 2019. PubMed
  2. Astrocyte lineage cells are essential for functional neuronal differentiation and synapse maturation in human iPSC-derived neural networks. Simon D Klapper, Pretty Garg, Sushma Dagar, Kerstin Lenk, Kurt Gottmann, Katja Nieweg. Glia. 2019 Oct;67(10):1893-1909. doi: 10.1002/glia.23666. Epub 2019 Jun 27. PubMed
  3. Release activity-dependent control of vesicle endocytosis by the synaptic adhesion molecule N-cadherin. Bernd van Stegen, Sushma Dagar, Kurt Gottmann. Sci Rep. 2017 Jan 20;7:40865. doi: 10.1038/srep40865. PubMed

Graduated 23.03.2016

PhD thesis
Interactions of dopaminergic and histaminergic systems in health and disease.

Supervisors

Publications

  1. Mechanisms of N-oleoyldopamine activation of central histaminergic neurons. De Luca R, Mazur K, Kernder A, Suvorava T, Kojda G, Haas HL, Sergeeva OA. Neuropharmacology. 2018 Dec;143:327-338. doi: 10.1016/j.neuropharm.2018.09.006. Epub 2018 Sep 13. PubMed

  2. N-oleoyldopamine modulates activity of midbrain dopaminergic neurons through multiple mechanisms. Sergeeva OA, De Luca R, Mazur K, Chepkova AN, Haas HL, Bauer A. Neuropharmacology. 2017 Jun;119:111-122. doi: 10.1016/j.neuropharm.2017.04.011. Epub 2017 Apr 9. PubMed

  3. Identification of histaminergic neurons through histamine 3 receptor-mediated autoinhibition. De Luca R, Suvorava T, Yang D, Baumgärtel W, Kojda G, Haas HL, Sergeeva OA. Neuropharmacology. 2016 Jul;106:102-15. doi: 10.1016/j.neuropharm.2015.08.025. Epub 2015 Aug 19. PubMed

  4. Associations among Exposure to Methylmercury, Reduced Reelin Expression, and gender in the Cerebellum of Developing Mice. Biamonte F, Latini L, Giorgi FS, Zingariello M, Marino R, De Luca R, D'Ilio S, Majorani C, Petrucci F, Violante N, Senofonte O, Molinari M, Keller F. Neurotoxicology. 2014 Dec;45:67-80. doi: 10.1016/j.neuro.2014.09.006. Epub 2014 Oct 14. PubMed

  5. Acid-Sensing Hypothalamic Neurons Controlling Arousal. Kernder A, De Luca R, Yanovsky Y, Haas HL, Sergeeva OA. 2014 Aug;34(6):777-89. doi: 10.1007/s10571-014-0065-6. Epub 2014 May 6. PubMed

Graduated 04.11.2020

PhD thesis
Establishment of an Adverse Outcome Pathway-informed testing battery for predicting Parkinsonian Motor Deficits in vitro.

Supervisor

Publications

  1. Animal Model for Leigh Syndrome. El-Desouky S, Taalab YM, El-Gamal M, Mohamed W, Salama M. Methods Mol Biol. 2019;2011:451-464. doi: 10.1007/978-1-4939-9554-7_27. PMID: 31273716 PubMed
  2. Literature review and appraisal on alternative neurotoxicity testing methods. Masjosthusmann S, Barenys M, El‐Gamal M, Geerts L, Gerosa L, Gorreja A, Kühne B, Marchetti N, Tigges J, Viviani B, Witters H. EFSA Supporting Publications. 2018 Apr;15(4):1410E.

Graduated 26.02.2021

PhD Thesis
Spontaneous Na+ fluctuations in the neonatal mouse brain.

Supervisors

Publications

  1. On the Origin of Ultraslow Spontaneous Na + Fluctuations in Neurons of the Neonatal Forebrain. Carlos Perez, Lisa Felix, Simone Durry, Christine R Rose, Ghanim Ullah. J Neurophysiol. 2020 Nov 25. doi: 10.1152/jn.00373.2020. Online ahead of print. PubMed

  2. Correction: Felix, L.; Ziemens, D.; Seifert, G.; Rose, C.R. Spontaneous. Ultraslow Na + Fluctuations in the Neonatal Mouse Brain. Lisa Felix, Daniel Ziemens, Gerald Seifert, Christine R Rose.  Cells 2020, 9, 102. Cells. 2020 Oct 30;9(11):E2380. doi: 10.3390/cells9112380. PubMed

  3. Sodium Fluctuations in Astroglia and Their Potential Impact on Astrocyte Function. Lisa Felix, Andrea Delekate, Gabor C Petzold, Christine R Rose. Front Physiol. 2020 Aug 12;11:871. doi: 10.3389/fphys.2020.00871. eCollection 2020. PubMed

  4. Astrocytes of the early postnatal brain. Felix L, Stephan J, Rose CR. Eur J Neurosci. 2020 May 14. doi: 10.1111/ejn.14780. Online ahead of print. PMID: 32406559 PubMed

  5. Spontaneous Ultraslow Na+ Fluctuations in the Neonatal Mouse Brain. Felix L, Ziemens D, Seifert G, Rose CR. Cells. 2019 Dec 31;9(1):102. doi: 10.3390/cells9010102. PMID: 31906100 PubMed

  6. Astroglial Glutamate Signaling and Uptake in the Hippocampus. Rose CR, Felix L, Zeug A, Dietrich D, Reiner A, Henneberger C. Front Mol Neurosci. 2018 Jan 17;10:451. doi: 10.3389/fnmol.2017.00451. eCollection 2017. PMID: 29386994 PubMed

Graduated 11.02.2016

PhD thesis
Differentiation and Characterization of Human Induced Pluripotent Stem Cell derived Astrocytes.

Supervisor

Publications

  1. Astrocyte lineage cells are essential for functional neuronal differentiation and synapse maturation in human iPSC-derived neural networks. Klapper SD, Garg P, Dagar S, Lenk K, Gottmann K, Nieweg K. Glia. 2019 Oct;67(10):1893-1909.doi: 10.1002/glia.23666. Epub 2019 Jun 27. PubMed
  2. The gut-brain axis in Parkinson's disease: A focus on the transport of α-Synuclein.  Sivaraj Mohana Sundaram, Pretty Garg. Mov Disord. 2019 Oct;34(10):1479. doi: 10.1002/mds.27842. Epub 2019 Sep 4. PubMed

Graduated 29.06.2016

PhD Thesis
Modeling behavioral and neuropathological phenotypes of brain diseases using in utero electroporation.

Supervisors

Publications

  1. Behavioral Resilience and Sensitivity to Locally Restricted Cortical Migration Deficits Induced by In Utero Knockdown of Disabled-1 in the Adult rat. Sandra Vomund, Maria Angelica de Souza Silva, Joseph P. Huston and Carsten Korth. Cereb Cortex. 2017 Mar 1;27(3):2052-2063. doi: 10.1093/cercor/bhw060. PubMed

  2. Generation of topically transgenic rats by in utero electroporation and in vivo bioluminescence screening. Sandra Vomund, Tamar Sapir, Orly Reiner, Maria Angelica de Souza Siva and Carsten Korth. J. Vis. Exp. (79), e50146, doi:10.3791/50146 (2013) PubMed

  3. Rational design of a minimal and highly enriched CYP102A1 mutant library with improved regio-, stereo- and chemoselectivity. Seifert A, Vomund S, Grohmann K, Kriening S, Urlacher VB, Laschat S, Pleiss J.Chembiochem. 2009 Mar 23;10(5):853-61. Erratum in: Chembiochem. 2009 Jun 15;10(9):1426 PubMed

Graduated 29.06.2016

PhD Thesis
Establishment of a hiPSC-based in vitro model to study environmental and genetic disturbances of neurodevelopmental processes.

Supervisors

Publications

  1. Rabbit neurospheres as a novel in vitro tool for studying neurodevelopmental effects induced by intrauterine growth restriction. Marta Barenys, Miriam Illa, Maxi Hofrichter, Carla Loreiro, Laura Pla, Jördis Klose, Britta Anna Kühne, Jesús Gómez-Catalán, Jan Matthias Braun, Fatima Crispi, Eduard Gratacós, Ellen Fritsche. Stem Cells Transl Med. 2020 Oct 9. doi: 10.1002/sctm.20-0223. Online ahead of print. PubMed

  2. Comparative performance analysis of human iPSC-derived and primary neural progenitor cells (NPC) grown as neurospheres in vitro. Maxi Hofrichter, Laura Nimtz, Julia Tigges, Yaschar Kabiri, Friederike Schröter, Brigitte Royer-Pokora, Barbara Hildebrandt, Martin Schmuck, Alexey Epanchintsev, Stephan Theiss, James Adjaye, Jean-Marc Egly, Jean Krutmann, Ellen Fritsche. Stem Cell Res. 2017 Dec;25:72-82. doi: 10.1016/j.scr.2017.10.013. Epub 2017 Oct 26. PubMed

  3. Dual roles of the adenosine A2a receptor in autoimmune neuroinflammation. Ingwersen J, Wingerath B, Graf J, Lepka K, Hofrichter M, Schröter F, Wedekind F, Bauer A, Schrader J, Hartung HP, Prozorovski T, Aktas O. J Neuroinflammation. 2016 Feb 26;13(1):48. doi: 10.1186/s12974-016-0512-z. PubMed

Graduated 30.10.2014

PhD thesis
Sodium dynamics in neurons and astrocytes under epileptiform conditions.

Supervisors

Publications

  1. Lactate rescues neuronal sodium homeostasis during impaired energy metabolism. Karus C, Ziemens D, Rose CR. Channels (Austin). 2015;9(4):200-8. doi: 10.1080/19336950.2015.1050163. Epub 2015 Jun 3. PubMed

  2. Astrocytes restrict discharge duration and neuronal sodium loads during recurrent network activity. Karus C, Mondragão MA, Ziemens D, Rose CR. Glia. 2015 Jun;63(6):936-57. doi: 10.1002/glia.22793. Epub 2015 Jan 29. PubMed

  3. Two sides of the same coin: sodium homeostasis and signaling in astrocytes under physiological and pathophysiological conditions. Rose CR, Karus C. (2013) Glia. 2013 Aug;61(8):1191-205. doi: 10.1002/glia.22492. Epub 2013 Apr 2. PubMed

Graduated November 2016

PhD thesis
Generation and investigation of a faithful model for familial Alzheimer´s disease with presenilin mutations.

Supervisors

Graduated 07.02.2017

PhD Thesis
Iron-sulfur cluster coordinating Glutaredoxins in neuroinflammatory degeneration and regeneration.

Supervisors

Publications

  1. The metalloprotease ADAMTS4 generates N-truncated Aβ4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease. Susanne Walter, Thorsten Jumpertz, Melanie Hüttenrauch, Isabella Ogorek, Hermeto Gerber, Steffen E Storck, Silvia Zampar, Mitko Dimitrov, Sandra Lehmann, Klaudia Lepka, Carsten Berndt, Jens Wiltfang, Christoph Becker-Pauly, Dirk Beher, Claus U Pietrzik, Patrick C Fraering, Oliver Wirths Sascha Weggen. Acta Neuropathol. 2019 Feb;137(2):239-257. doi: 10.1007/s00401-018-1929-5. Epub 2018 Nov 13 PubMed

  2. Iron-sulfur glutaredoxin 2 protects oligodendrocytes against damage induced by nitric oxide release from activated microglia. Lepka K, Volbracht K, Bill E, Schneider R, Rios N, Hildebrandt T, Ingwersen J, Prozorovski T, Lillig CH, van Horssen J, Steinman L, Hartung HP, Radi R, Holmgren A, Aktas O, Berndt C. Glia. 2017 Sep;65(9):1521-1534. doi: 10.1002/glia.23178. Epub 2017 Jun 15. PubMed

  3. Redox Events As Modulators of Pathology and Therapy of Neuroinflammatory Diseases. Lepka K, Berndt C, Hartung HP, Aktas O. Front Cell Dev Biol. 2016 Jun 23;4:63. doi: 10.3389/fcell.2016.00063. eCollection 2016. PubMed

  4. Dual roles of the adenosine A2a receptor in autoimmune neuroinflammation. Ingwersen J, Wingerath B, Graf J, Lepka K, Hofrichter M, Schröter F, Wedekind F, Bauer A, Schrader J, Hartung HP, Prozorovski T, Aktas O. J Neuroinflammation. 2016 Feb 26;13(1):48. doi: 10.1186/s12974-016-0512-z. PubMed

  5. Redox regulation of cytoskeletal dynamics during differentiation and de-differentiation. Gellert M, Hanschmann EM, Lepka K, Berndt C, Lillig CH. Biochim Biophys Acta. 2015 Aug;1850(8):1575-87. doi: 10.1016/j.bbagen.2014.10.030. Epub 2014 Nov 8. PubMed

  6. Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1. Bräutigam L, Jensen LD, Poschmann G, Nyström S, Bannenberg S, Dreij K, Lepka K, Prozorovski T, Montano SJ, Aktas O, Uhlén P, Stühler K, Cao Y, Holmgren A, Berndt C. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20057-62. doi: 10.1073/pnas.1313753110. Epub 2013 Nov 25. PubMed

Graduated 23.02.2021

PhD Thesis
Chronic effects of environmental pollutants in the nematode Caenorhabditis elegans: Signaling pathways, aging processes and neurodegeneration.

Supervisors

Publications

  1. The Nucleus of Intestinal Cells of the Bacterivore Nematode Caenorhabditis elegans as a Sensitive Sensor of Environmental Pollutants. Annette Piechulek, Lutz Berwanger, Peter Hemmerich, Anna von Mikecz. Methods Mol Biol. 2020;2175:207-217. doi: 10.1007/978-1-0716-0763-3_15. PubMed

  2. Silica nanoparticles disrupt OPT-2/PEP-2-dependent trafficking of nutrient peptides in the intestinal epithelium. Piechulek A, Berwanger LC, von Mikecz A. Nanotoxicology. 2019 Oct;13(8):1133-1148. doi: 10.1080/17435390.2019.1643048. Epub 2019 Aug 9. PMID: 31340706 PubMed

  3. Aging by pollutants: introducing the aging dose (AD)50. Piechulek, A. & von Mikecz, A. Environ Sci Eur 31, 23 (2019). Springer

  4. Life span-resolved nanotoxicology enables identification of age-associated neuromuscular vulnerabilities in the nematode Caenorhabditis elegans. Piechulek A, von Mikecz A. Environ Pollut. 2018 Feb;233:1095-1103. doi: 10.1016/j.envpol.2017.10.012. Epub 2017 Oct 12. PMID: 29031405 PubMed

  5. Effect of nanoparticles on the biochemical and behavioral aging phenotype of the nematode Caenorhabditis elegans. Scharf A, Piechulek A, von Mikecz A. ACS Nano. 2013 Dec 23;7(12):10695-703. doi: 10.1021/nn403443r. Epub 2013 Nov 23. PMID: 24256469  PubMed

Graduated 12.09.2019

PhD Thesis
Protein missassembly in chronic mental illnesses.

Supervisor

Publications

  1. Disruption of cellular proteostasis by H1N1 influenza A virus causes α-synuclein aggregation. Rita Marreiros, Andreas Müller-Schiffmann, Svenja V Trossbach, Ingrid Prikulis , Sebastian Hänsch, Stefanie Weidtkamp-Peters, Ana Raquel Moreira, Shriya Sahu, Irina Soloviev, Suganya Selvarajah, Vishwanath R Lingappa, Carsten Korth. Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6741-6751. doi: 10.1073/pnas.1906466117. Epub 2020 Mar 9. PubMed

  2. Biophysical insights from a single chain camelid antibody directed against the Disrupted-in-Schizophrenia 1 protein. Antony S K Yerabham  1 , Andreas Müller-Schiffmann  1 , Tamar Ziehm  2 , Andreas Stadler, Sabrina Köber, Xela Indurkhya, Rita Marreiros, Svenja V Trossbac, Nicholas J Bradshaw, Ingrid Prikulis, Dieter Willbold, Oliver H Weiergräber, Carsten Korth. PLoS One. 2018 Jan 11;13(1):e0191162. doi: 10.1371/journal.pone.0191162. eCollection 2018. PubMed

  3. An unpredicted aggregation-critical region of the actin-polymerizing protein TRIOBP-1/Tara, determined by elucidation of its domain structure. Nicholas J Bradshaw, Antony S K Yerabham, Rita Marreiros, Tao Zhang, Luitgard Nagel-Steger, Carsten Korth. J Biol Chem. 2017 Jun 9;292(23):9583-9598.doi: 10.1074/jbc.M116.767939. Epub 2017 Apr 24. PubMed

  4. Revisiting rodent models: Octodon degus as Alzheimer's disease model? Johannes Steffen, Markus Krohn, Kristin Paarmann, Christina Schwitlick, Thomas Brüning, Rita Marreiros, Andreas Müller-Schiffmann, Carsten Korth, Katharina Braun, Jens Pahnke. Acta Neuropathol Commun. 2016 Aug 26;4(1):91. doi: 10.1186/s40478-016-0363-y. PubMed

  5. Viral capsid assembly as a model for protein aggregation diseases: Active processes catalyzed by cellular assembly machines comprising novel drug targets. Rita Marreiros, Andreas Müller-Schiffmann, Verian Bader, Suganya Selvarajah, Debendranath Dey, Vishwanath R Lingappa, Carsten Korth. Virus Res. 2015 Sep 2;207:155-64. doi: 10.1016/j.virusres.2014.10.003. Epub 2014 Oct 25. PubMed

Graduated 25.06.2018

PhD thesis
Cell specific analysis of AMPA receptor complexes in development and disease.

Supervisors

Publications

  1. Heterogeneity of the astrocytic AMPA-receptor transcriptome. Mölders A, Koch A, Menke R, Klöcker N. Glia. 2018 Dec;66(12):2604-2616. doi: 10.1002/glia.23514. Epub 2018 Oct 28. PubMed

  2. Depletion of the AMPAR reserve pool impairs synaptic plasticity in a model of hepatic encephalopathy. Schroeter A, Wen S, Mölders A, Erlenhardt N, Stein V, Klöcker N. Mol Cell Neurosci. 2015 Sep;68:331-9. doi: 10.1016/j.mcn.2015.09.001. Epub 2015 Sep 9. PubMed

  3. Ontogeny repeats the phylogenetic recruitment of the cargo exporter cornichon into AMPA receptor signaling complexes. Mauric V, Mölders A, Harmel N, Heimrich B, Sergeeva OA, Klöcker N. (2013) Mol Cell Neurosci. 2013 Sep;56C:10-17. doi: 10.1016/j.mcn.2013.02.001. Epub 2013 Feb 8. Pubmed

Graduated 13.12.2018

PhD thesis
Na+ signaling in white matter glial cells.

Supervisors

Publications

  1. Astrocyte Sodium Signalling and Panglial Spread of Sodium Signals in Brain White Matter. Behrouz Moshrefi-Ravasdjani, Evelyn L Hammel, Karl W Kafitz, Christine R Rose. Neurochem Res. 2017 Sep;42(9):2505-2518. doi: 10.1007/s11064-017-2197-9. Epub 2017 Feb 18. PubMed

  2. Rapid sodium signaling couples glutamate uptake to breakdown of ATP in perivascular astrocyte endfeet. Julia Langer, Niklas J Gerkau, Amin Derouiche, Christian Kleinhans, Behrouz Moshrefi-Ravasdjani, Michaela Fredrich, Karl W Kafitz, Gerald Seifert, Christian Steinhäuser, Christine R Rose. Glia. 2017 Feb;65(2):293-308. doi: 10.1002/glia.23092. Epub 2016 Oct 27. PubMed

  3. Changes in the proliferative capacity of NG2 cell subpopulations during postnatal development of the mouse hippocampus. Behrouz Moshrefi-Ravasdjani, Pavel Dublin, Gerald Seifert, Katja Jennissen, Christian Steinhäuser Karl W Kafitz, Christine R Rose. Brain Struct Funct. 2017 Mar;222(2):831-847. doi: 10.1007/s00429-016-1249-2. Epub 2016 Jun 15. PubMed

Graduated 19.09.2015

PhD Thesis
Neurochemical mechanisms of motoric, cognitive and affective functions in the hemiparkinsonian rat model.

Supervisors

Publications

  1. Rats bred for helplessness exhibit positive reinforcement learning deficits which are not alleviated by an antidepressant dose of the MAO-B inhibitor deprenyl. Schulz D, Henn FA, Petri D, Huston JP. Neuroscience. 2016 Aug 4;329:83-92. doi: 10.1016/j.neuroscience.2016.04.049. Epub 2016 May 6. PubMed

  2. Evidence for a Specific Integrative Mechanism for Episodic Memory Mediated by AMPA/kainate Receptors in a Circuit Involving Medial Prefrontal Cortex and Hippocampal CA3 Region. de Souza Silva MA, Huston JP, Wang AL, Petri D, Chao OY. Cereb Cortex. 2016 Jul;26(7):3000-9. doi: 10.1093/cercor/bhv112. Epub 2015 Jun 5. PubMed

  3. Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans. Trenado C, Elben S, Petri D, Hirschmann J, Groiss SJ, Vesper J, Schnitzler A, Wojtecki L. J Vis Exp. 2016 May 19;(111). doi: 10.3791/53466. PubMed

  4. Serotonergic interaction between medial prefrontal cortex and mesotelencephalic DA system underlies cognitive and affective deficits in hemiparkinsonian rats. Petri D, de Souza Silva MA, Chao OY, Schnitzler A, Huston JP. Neuroscience. 2015 Oct 29;307:51-63. doi: 10.1016/j.neuroscience.2015.08.022. Epub 2015 Aug 24. PubMed

  5. Dopamine in the nucleus accumbens core, but not shell, increases during signaled food reward and decreases during delayed extinction. Biesdorf C, Wang AL, Topic B, Petri D, Milani H, Huston JP, de Souza Silva MA. 2015 Sep;123:125-39. doi: 10.1016/j.nlm.2015.06.002. Epub 2015 Jun 10. PubMed

  6. Modulation of central thalamic oscillations during emotional-cognitive processing in chronic disorder of consciousness. Wojtecki L, Petri D, Elben S, Hirschmann J, Yelnik J, Eickhoff S, Vesper J, Schnitzler A. (2014) Cortex. 2014 Nov;60:94-102. PubMed

  7. GABAA-receptor activation in the subthalamic nucleus compensates behavioral asymmetries in the hemiparkinsonian rat. Petri D, Pum M, Vesper J, Huston JP, Schnitzler A. (2013) Behav Brain Res. 2013 Sep 1;252:58-67. doi: 10.1016/j.bbr.2013.05.044. Epub 2013 May 30. PubMed

Graduated 13.03.2020

PhD thesis
Experimental studies concerning the unfolded protein response in glioma pathogenesis.

Supervisors

Publications

  1. A Multi-Omics Analysis Reveals the Unfolded Protein Response Regulon and Stress-Induced Resistance to Folate-Based Antimetabolites. Stefan Reich, Chi D L Nguyen, Canan Has, Sascha Steltgens, Himanshu Soni, Cristina Coman, Moritz Freyberg, Anna Bichler, Nicole Seifert, Dominik Conrad, Christiane B Knobbe-Thomsen, Björn Tews, Grischa Toedt, Robert Ahrends, Jan Medenbach. Nat Commun. 2020 Jun 10;11(1):2936.doi: 10.1038/s41467-020-16747-y. PubMed

  2. A sensitive and simple targeted proteomics approach to quantify transcription factor and membrane proteins of the unfolded protein response pathway in glioblastoma cells. Nguyen CDL, Malchow S, Reich S, Steltgens S, Shuvaev KV, Loroch S, Lorenz C, Sickmann A, Knobbe-Thomsen CB, Tews B, Medenbach J, Ahrends R. Sci Rep. 2019 Jun 20;9(1):8836. doi: 10.1038/s41598-019-45237-5. PubMed

Graduated 24.05.2019

PhD Thesis
Role of CXCR4 in mediating axon sprouting after local intrathecal infusion of CXCL12 in a mouse model of spinal cord injury.

Supervisors

Graduated 31.07.2017

PhD thesis
Investigations of the structural organization of the Disrupted-in-Schizophrenia 1 (DISC1) protein, a major risk factor for mental illness.

Supervisor

Publications

  1. Biophysical insights from a single chain camelid antibody directed against the Disrupted-in-Schizophrenia 1 protein. Antony S K Yerabham  1 , Andreas Müller-Schiffmann  1 , Tamar Ziehm  2 , Andreas Stadler, Sabrina Köber, Xela Indurkhya, Rita Marreiros, Svenja V Trossbac, Nicholas J Bradshaw, Ingrid Prikulis, Dieter Willbold, Oliver H Weiergräber, Carsten Korth. PLoS One. 2018 Jan 11;13(1):e0191162. doi: 10.1371/journal.pone.0191162. eCollection 2018. PubMed

  2. An unpredicted aggregation-critical region of the actin-polymerizing protein TRIOBP-1/Tara, determined by elucidation of its domain structure. Nicholas J Bradshaw, Antony S K Yerabham, Rita Marreiros, Tao Zhang, Luitgard Nagel-Steger, Carsten Korth. J Biol Chem. 2017 Jun 9;292(23):9583-9598.doi: 10.1074/jbc.M116.767939. Epub 2017 Apr 24. PubMed

  3. A structural organization for the Disrupted in Schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions, which are bisected by mental illness-related mutations. Antony S K Yerabham, Philippe J Mas, Christina Decker, Dinesh C Soares, Oliver H Weiergräber, Luitgard Nagel-Steger, Dieter Willbold, Darren J Hart, Nicholas J Bradshaw, Carsten Korth. J Biol Chem. 2017 Apr 21;292(16):6468-6477. doi: 10.1074/jbc.M116.773903. Epub 2017 Mar 1. PubMed

  4. Revisiting disrupted-in-schizophrenia 1 as a scaffold protein. Antony S K Yerabham, Oliver H Weiergräber, Nicholas J Bradshaw, Carsten Korth. Biol Chem. 2013 Nov;394(11):1425-37. doi: 10.1515/hsz-2013-0178. PubMed

     

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