PhD Researchers

PhD Thesis
Impact of genotoxins on autophagic processes during neuronal differentiation.

Supervisor

• Prof. Dr. Björn Stork

• Prof. Dr. James Adjaye

• Prof. Dr. Charlotte von Gall

Publications

1. Modulation of Specific Sphingosine-1-Phosphate Receptors Augments a Repair Mediating Schwann Cell Phenotype. Jessica Schira-Heinen, Luzhou Wang, Seda Akgün, Sofia Blum, Brigida Ziegler, André Heinen, Hans-Peter Hartung, Patrick Küry. Int J Mol Sci. 2022 Sep 7;23(18):10311. doi: 10.3390/ijms231810311. PubMed
2. Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells. Yadong Sun, Niklas Berleth, Wenxian Wu, David Schlütermann, Jana Deitersen, Fabian Stuhldreier, Lena Berning, Annabelle Friedrich, Seda Akgün, María José Mendiburo, Sebastian Wesselborg, Marcus Conrad, Carsten Berndt, Björn Stork. Cell Death Dis. 2021 Oct 29;12(11):1028. doi: 10.1038/s41419-021-04306-2. PubMed

PhD Thesis
Unfolding the mechanisms of a cell death type induced under glucose starvation.

Supervisors

• Prof. Dr. Guido Reifenberger

• Prof. Dr. Sebastian Wesselborg

PhD Thesis
Physiologische Eigenschaften Na+-abhängiger GABA Transporter 

Supervisors

• Prof. Dr. Christine Rose
• Prof. Dr. Dieter WIllbold

PhD Thesis

Molecular mechanisms regulating the differentiation potential of neural stem and progenitor cells upon gamma irradiation.

Supervisors

• Prof. Dr. Christine Rose
• Dr. Christiane Knobbe-Thomsen

PhD Thesis
Neural mechanisms of affective processing, reward and cognition in the context of social behaviour.

Supervisors

• Prof. Dr. Tobias Kalenscher

• Prof. Dr. Carsten Korth

PhD Thesis
Ion homeostasis and acute metabolic inhibition in the murine brain.

Supervisors

• Prof. Dr. Christine Rose
• Prof. Dr. Dieter Willbold

Publications

1. Novel algorithms for improved detection and analysis of fluorescent signal fluctuations. Gebhard Stopper, Laura C Caudal, Phillip Rieder, Davide Gobbo, Laura Stopper, Lisa Felix, Katharina Everaerts, Xianshu Bai, Christine R Rose, Anja Scheller, Frank Kirchhoff. Pflugers Arch. 2023 Sep 13. doi: 10.1007/s00424-023-02855-3. [Epub ahead of print] PubMed
2. Cell-Type Dependent Regulation of the Electrogenic Na +/HCO 3- Cotransporter 1 (NBCe1) by Hypoxia and Acidosis in Glioblastoma. Marina Giannaki, Debora E Ruf, Emilie Pfeifer, Katharina Everaerts, Dieter H Heiland, Oliver Schnell, Christine R Rose, Eleni Roussa. Int J Mol Sci. 2022 Aug 11;23(16):8975. doi: 10.3390/ijms23168975. PubMed
3. Changes in Astroglial K + upon Brief Periods of Energy Deprivation in the Mouse Neocortex. Sara Eitelmann, Jonathan Stephan, Katharina Everaerts, Simone Durry, Nils Pape, Niklas J Gerkau, Christine R Rose. Int J Mol Sci. 2022 Apr 27;23(9):4836. doi: 10.3390/ijms23094836. PubMed

PhD Thesis
Modulation of interactions between microglial cells and myelinated axons in response to the HERV-W envelope protein.

Supervisors

• Prof. Dr. Patrick Küry

• Prof. Dr. Hermann Aberle

Publications

1. Transgenic expression of the HERV-W envelope protein leads to polarized glial cell populations and a neurodegenerative environment. Joel Gruchot, Isabel Lewen, Michael Dietrich, Laura Reiche, Mustafa Sindi, Christina Hecker, Felisa Herrero, Benjamin Charvet, Ulrike Weber-Stadlbauer, Hans-Peter Hartung, Philipp Albrecht, Hervé Perron, Urs Meyer, Patrick Küry. Proc Natl Acad Sci U S A. 2023 Sep 19;120(38):e2308187120. doi: 10.1073/pnas.2308187120. Epub 2023 Sep 11. PubMed

2. A Novel Ex Vivo Model to Study Therapeutic Treatments for Myelin Repair following Ischemic Damage. Luisa Werner, Michael Gliem, Nicole Rychlik, Goran Pavic, Laura Reiche, Frank Kirchhoff, Markley Silva Oliveira Junior, Joel Gruchot, Sven G Meuth, Patrick Küry, Peter Göttle. Int J Mol Sci. 2023 Jun 30;24(13):10972. doi: 10.3390/ijms241310972. PubMed

3. Teriflunomide as a therapeutic means for myelin repair. Peter Göttle, Janos Groh, Laura Reiche, Joel Gruchot, Nicole Rychlik, Luisa Werner, Iria Samper Agrelo, Rainer Akkermann, Annika Zink, Alessandro Prigione, Hans-Peter Hartung, Rudolf Martini, Patrick Küry. J Neuroinflammation. 2023 Jan 7;20(1):7. doi: 10.1186/s12974-022-02686-6. PubMed

4. Susceptibility and resilience to maternal immune activation are associated with differential expression of endogenous retroviral elements. Felisa Herrero, Flavia S Mueller, Joel Gruchot, Patrick Küry, Ulrike Weber-Stadlbauer, Urs Meyer. Brain Behav Immun. 2023 Jan;107:201-214. doi: 10.1016/j.bbi.2022.10.006. Epub 2022 Oct 12. PubMed

5. Interplay between activation of endogenous retroviruses and inflammation as common pathogenic mechanism in neurological and psychiatric disorders. Joel Gruchot, Felisa Herrero, Ulrike Weber-Stadlbauer, Urs Meyer, Patrick Küry. Brain Behav Immun. 2023 Jan;107:242-252. doi: 10.1016/j.bbi.2022.10.007. Epub 2022 Oct 18. PubMed

6. Cladribine treatment improves cortical network functionality in a mouse model of autoimmune encephalomyelitis. Christina B Schroeter, Leoni Rolfes, K S Sophie Gothan, Joel Gruchot, Alexander M Herrmann, Stefanie Bock, Luca Fazio, Antonia Henes, Venu Narayanan, Steffen Pfeuffer, Christopher Nelke, Saskia Räuber, Niklas Huntemann, Eduardo Duarte-Silva, Vera Dobelmann, Petra Hundehege, Heinz Wiendl, Katharina Raba, Patrick Küry, David Kremer, Tobias Ruck, Thomas Müntefering, Thomas Budde, Manuela Cerina, Sven G Meuth. J Neuroinflammation. 2022 Nov 8;19(1):270. doi: 10.1186/s12974-022-02588-7. PubMed

7. Siponimod Modulates the Reaction of Microglial Cells to Pro-Inflammatory Stimulation. Joel Gruchot, Ferdinand Lein, Isabel Lewen, Laura Reiche, Vivien Weyers, Patrick Petzsch, Peter Göttle, Karl Köhrer, Hans-Peter Hartung, Patrick Küry, David Kremer. J Neuroinflammation. 2022 Nov 8;19(1):270. doi: 10.1186/s12974-022-02588-7. PubMed

8. Deficiency of the two-pore potassium channel KCNK9 impairs intestinal epithelial cell survival and aggravates dextran sodium sulfate-induced colitis: The role of K2P channels in intestinal inflammation. Steffen Pfeuffer, Thomas Müntefering, Leoni Rolfes, Frederike Anne Straeten, Susann Eichler, Joel Gruchot, Vera Dobelmann, Tim Prozorovski, Boris Görg, Mihael Vucur, Carsten Berndt, Patrick Küry, Tobias Ruck, Stefan Bittner, Dominik Bettenworth, Thomas Budde, Tom Lüdde, Sven G Meuth. Cell Mol Gastroenterol Hepatol. 2022;14(6):1199-1211. doi: 10.1016/j.jcmgh.2022.08.003. Epub 2022 Aug 13. PubMed

9. Myelin repair is fostered by the corticosteroid medrysone specifically acting on astroglial subpopulations. Markley Silva Oliveira Junior, Jessica Schira-Heinen, Laura Reiche, Seulki Han, Vanessa Cristina Meira de Amorim, Isabel Lewen, Joel Gruchot, Peter Göttle, Rainer Akkermann, Kasum Azim, Patrick Küry. EBioMedicine. 2022 Aug 8;83:104204. doi: 10.1016/j.ebiom.2022.104204. Online ahead of print. PubMed

10. Increased Remyelination and Proregenerative Microglia Under Siponimod Therapy in Mechanistic Models. Michael Dietrich, Christina Hecker, Elodie Martin, Dominique Langui, Michael Gliem, Bruno Stankoff, Catherine Lubetzki, Joel Gruchot, Peter Göttle, Andrea Issberner, Milad Nasiri, Pamela Ramseier, Christian Beerli, Sarah Tisserand, Nicolau Beckmann, Derya Shimshek, Patrick Petzsch, David Akbar, Bodo Levkau, Holger Stark, Karl Köhrer, Hans-Peter Hartung, Patrick Küry, Sven Günther Meuth, Marc Bigaud, Bernard Zalc, Philipp Albrecht. Neurol Neuroimmunol Neuroinflamm. 2022 Mar 30;9(3):e1161. doi: 10.1212/NXI.0000000000001161. Print 2022 May. PubMed

11. Translational value of choroid plexus imaging for tracking neuroinflammation in mice and humans. Vinzenz Fleischer, Gabriel Gonzalez-Escamilla, Dumitru Ciolac, Philipp Albrecht, Patrick Küry, Joel Gruchot, Michael Dietrich, Christina Hecker, Thomas Müntefering, Stefanie Bock, Mohammadsaleh Oshaghi, Angela Radetz, Manuela Cerina, Julia Krämer, Lydia Wachsmuth, Cornelius Faber, Hans Lassmann, Tobias Ruck, Sven G Meuth, Muthuraman Muthuraman, Sergiu Groppa. Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2025000118. doi: 10.1073/pnas.2025000118. PubMed

12. Identification of novel myelin repair drugs by modulation of oligodendroglial differentiation competence. Anastasia Manousi, Peter Göttle, Laura Reiche, Qiao-Ling Cui, Luke M Healy, Rainer Akkermann, Joel Gruchot, Jessica Schira-Heinen, Jack P Antel, Hans-Peter Hartung, Patrick Küry. EBioMedicine. 2021 Mar;65:103276. doi: 10.1016/j.ebiom.2021.103276. Epub 2021 Mar 10. PubMed

13. Meeting report: "Human endogenous retroviruses: HERVs or transposable elements in autoimmune, chronic inflammatory and degenerative diseases or cancer", Lyon, France, november 5th and 6th 2019 - an MS scientist's digest. Kremer D, Weyers V, Gruchot J, Göttle P, Hartung HP, Perron H, Küry P. Mult Scler Relat Disord. 2020 Jul;42:102068. doi: 10.1016/j.msard.2020.102068. Epub 2020 Apr 8. PubMed

14. Human endogenous retroviruses: ammunition for myeloid cells in neurodegenerative diseases? Gruchot J, Kremer D, Küry P. Neural Regen Res. 2020 Jun;15(6):1043-1044. doi: 10.4103/1673-5374.270311. PubMed

15. The Molecular Basis for Remyelination Failure in Multiple Sclerosis. Gruchot J, Weyers V, Göttle P, Förster M, Hartung HP, Küry P, Kremer D. Cells. 2019 Aug 3;8(8):825. doi: 10.3390/cells8080825. PubMed

16. Neural Cell Responses Upon Exposure to Human Endogenous Retroviruses. Gruchot J, Kremer D, Küry P. Front Genet. 2019 Jul 11;10:655. doi: 10.3389/fgene.2019.00655. eCollection 2019. PubMed

17. pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis. Kremer D, Gruchot J, Weyers V, Oldemeier L, Göttle P, Healy L, Ho Jang J, Kang T Xu Y, Volsko C, Dutta R, Trapp BD, Perron H, Hartung HP, Küry P. Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):15216-15225. doi: 10.1073/pnas.1901283116. Epub 2019 Jun 18. PubMed

18. Rescuing the negative impact of human endogenous retrovirus envelope protein on oligodendroglial differentiation and myelination. Göttle P, Förster M, Gruchot J, Kremer D, Hartung HP, Perron H, Küry P. Glia. 2019 Jan;67(1):160-170. doi: 10.1002/glia.23535. Epub 2018 Nov 14. PubMed

PhD Thesis
Dissecting the neural pathology of Leigh syndrome using patient-derived brain organoids.

Supervisors

• Prof. Dr. Alessandro Prigione
• Prof. Dr. Matias Zurbriggen

PhD Thesis
Natural compounds as suppressors of mitochondrial complex I deficiency-associated diseases in mammalian cell models.

Supervisor

• MD, PhD, PD Natascia Ventura

• Prof. Dr. Andreas Reichert

PhD Thesis
Hypoxia and sirtuin 1 in neural stem & progenitor cells.

Supervisors

• PD Dr. Carsten Berndt

• Prof. Dr. Andreas Reichert

PhD Thesis
Life span-resolved nanotoxicology: amyloid aggregation, neuronal targets and vulnerable age-groups in the nematode Caenorhabditis elegans.

Supervisors

• Prof. Dr. Anna von Mikecz

• Prof. Dr. Dieter Willbold

Publications

1. Peripheral neuropathy, protein aggregation and serotonergic neurotransmission: Distinctive bio-interactions of thiacloprid and thiamethoxam in the nematode Caenorhabditis elegans. Inge Scharpf, Sylwia Cichocka, Dang Tri Le, Anna von Mikecz. Environ Pollut. 2022 Dec 1;314:120253.doi: 10.1016/j.envpol.2022.120253. Epub 2022 Sep 23. PubMed
2. How to keep up with the analysis of classic and emerging neurotoxins: Age-resolved fitness tests in the animal model Caenorhabditis elegans - a step-by-step protocol. Indra Hering, Dang Tri Le, Anna von Mikecz. EXCLI J. 2022 Jan 31;21:344-353. doi: 10.17179/excli2021-4626. eCollection 2022. PubMed

PhD Thesis
Brain organoids for modelling Leigh syndrome caused by complex I mutations.

Supervisor

• Prof. Dr. Alessandro Prigione

Publication

1. Activated microglia and neuroinflammation as a pathogenic mechanism in Leigh syndrome. Nastaran Daneshgar, Mariah R Leidinger, Stephanie Le, Marco Hefti, Alessandro Prigione, Dao-Fu Dai. Front Neurosci. 2023 Jan 18;16:1068498. doi: 10.3389/fnins.2022.1068498. eCollection 2022. PubMed

PhD Thesis
Establishment of a glioblastoma model in Drosophila melanogaster as a tool for functional genomics screening

Supervisors

• Prof. Dr. Guido Reifenberger
• Prof. Dr. Thomas Klein

PhD Thesis
Genetic knock-down screenings in human iPSC-derived neurons.

Supervisor

• Prof. Dr. Alessandro Prigione

• Dr. Sidney Cambridge

Publications

1. High-content analysis of neuronal morphology in human iPSC-derived neurons. Selene Lickfett, Carmen Menacho, Annika Zink, Narasimha Swamy Telugu, Mathias Beller, Sebastian Diecke, Sidney Cambridge, Alessandro Prigione. STAR Protoc. 2022 Aug 6;3(3):101567. doi: 10.1016/j.xpro.2022.101567. eCollection 2022 Sep 16. PubMed

2. A call for consensus guidelines on monitoring the integrity of nuclear and mitochondrial genomes in human pluripotent stem cells. Andrea Rossi, Selene Lickfett, Soraia Martins, Alessandro Prigione. Stem Cell Reports. 2022 Apr 12;17(4):707-710.doi: 10.1016/j.stemcr.2022.01.019. Epub 2022 Mar 3. PubMed

PhD Thesis
Revealing the pathological mechanism of neural impairment of Leigh syndrome using engineered patient-derived neural cells.

Supervisor

• Prof. Dr. Alessandro Prigione

Publications

1. High-content analysis of neuronal morphology in human iPSC-derived neurons. Selene Lickfett, Carmen Menacho, Annika Zink, Narasimha Swamy Telugu, Mathias Beller, Sebastian Diecke, Sidney Cambridge, Alessandro Prigione. STAR Protoc. 2022 Aug 6;3(3):101567. doi: 10.1016/j.xpro.2022.101567. eCollection 2022 Sep 16. PubMed
2. Generation of Human Brain Organoids for Mitochondrial Disease Modeling. Le S, Petersilie L, Inak G, Menacho-Pando C, Kafitz KW, Rybak-Wolf A, Rajewsky N, Rose CR, Prigione A. J Vis Exp. 2021 Jun 21;(172). doi: 10.3791/62756. PubMed

PhD Thesis
Effects of energy deprivation on cellular ion homeostasis in the mouse brain.

Supervisors

• Prof. Dr. Christine Rose

• Jun.-Prof. Dr. Nadine Erlenhardt

Publications

1. Activation of TRPV4 channels promotes the loss of cellular ATP in organotypic slices of the mouse neocortex exposed to chemical ischemia. Nils Pape, Christine R Rose. 2023 Jul;601(14):2975-2990.doi: 10.1113/JP284430. Epub 2023 Jun 6. PubMed
2. Modeling the heterogeneity of sodium and calcium homeostasis between cortical and hippocampal astrocytes and its impact on bioenergetics. Pawan Thapaliya, Nils Pape, Christine R Rose, Ghanim Ullah. Front Cell Neurosci. 2023 Jan 30;17:1035553. doi: 10.3389/fncel.2023.1035553. eCollection 2023. PubMed
3. Changes in Astroglial K + upon Brief Periods of Energy Deprivation in the Mouse Neocortex. Sara Eitelmann, Jonathan Stephan, Katharina Everaerts, Simone Durry, Nils Pape, Niklas J Gerkau, Christine R Rose. Int J Mol Sci. 2022 Apr 27;23(9):4836. doi: 10.3390/ijms23094836. PubMed

PhD Thesis
Influence of metabolic inhibition on the ion homeostasis of brain cells.

Supervisors

• Prof. Dr. Christine Rose

• Prof. Dr. Ellen Fritsche

Publications

1. Glial Chloride Homeostasis Under Transient Ischemic Stress. Miriam Engels, Manu Kalia, Sarah Rahmati, Laura Petersilie, Peter Kovermann, Michel J A M van Putten, Christine R Rose, Hil G E Meijer, Thomas Gensch, Christoph Fahlke. Front Cell Neurosci. 2021 Sep 16;15:735300. doi: 10.3389/fncel.2021.735300. eCollection 2021. PubMed

2. Human Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Produce Distinct Neural 3D In Vitro Models Depending on Alginate/Gellan Gum/Laminin Hydrogel Blend Properties. Kapr J, Petersilie L, Distler T, Lauria I, Bendt F, Sauter CM, Boccaccini AR, Rose CR, Fritsche E. Adv Healthc Mater. 2021 Aug;10(16):e2100131. doi: 10.1002/adhm.202100131. Epub 2021 Jul 1. PubMed

3. Generation of Human Brain Organoids for Mitochondrial Disease Modeling. Le S, Petersilie L, Inak G, Menacho-Pando C, Kafitz KW, Rybak-Wolf A, Rajewsky N, Rose CR, Prigione A. J Vis Exp. 2021 Jun 21;(172). doi: 10.3791/62756. PubMed

4. Altered Gap Junction Network Topography in Mouse Models for Human Hereditary Deafness. Sara Eitelmann, Laura Petersilie, Christine R Rose, Jonathan Stephan. Int J Mol Sci. 2020 Oct 6;21(19):7376. doi: 10.3390/ijms21197376. PubMed

PhD Thesis
C21orf91 as a novel modulator of glial cell determination and differentiation.

Supervisors

• Prof. Dr. Patrick Küry

• Prof. Dr. Christine R. Rose

Publications

1. Star power: harnessing the reactive astrocyte response to promote remyelination in multiple sclerosis. Markley Silva Oliveira Junior, Laura Reiche, Emerson Daniele, Ines Kortebi, Maryam Faiz, Patrick Küry. Neural Regen Res. 2024 Mar;19(3):578-582. doi: 10.4103/1673-5374.380879. PubMed

2. Transgenic expression of the HERV-W envelope protein leads to polarized glial cell populations and a neurodegenerative environment. Joel Gruchot, Isabel Lewen, Michael Dietrich, Laura Reiche, Mustafa Sindi, Christina Hecker, Felisa Herrero, Benjamin Charvet, Ulrike Weber-Stadlbauer, Hans-Peter Hartung, Philipp Albrecht, Hervé Perron, Urs Meyer, Patrick Küry. Proc Natl Acad Sci U S A. 2023 Sep 19;120(38):e2308187120. doi: 10.1073/pnas.2308187120. Epub 2023 Sep 11. PubMed

3. A Novel Ex Vivo Model to Study Therapeutic Treatments for Myelin Repair following Ischemic Damage. Luisa Werner, Michael Gliem, Nicole Rychlik, Goran Pavic, Laura Reiche, Frank Kirchhoff, Markley Silva Oliveira Junior, Joel Gruchot, Sven G Meuth, Patrick Küry, Peter Göttle. Int J Mol Sci. 2023 Jun 30;24(13):10972. doi: 10.3390/ijms241310972. PubMed

4. Teriflunomide as a therapeutic means for myelin repair. Peter Göttle, Janos Groh, Laura Reiche, Joel Gruchot, Nicole Rychlik, Luisa Werner, Iria Samper Agrelo, Rainer Akkermann, Annika Zink, Alessandro Prigione, Hans-Peter Hartung, Rudolf Martini, Patrick Küry. J Neuroinflammation. 2023 Jan 7;20(1):7. doi: 10.1186/s12974-022-02686-6. PubMed

5. Siponimod Modulates the Reaction of Microglial Cells to Pro-Inflammatory Stimulation. Joel Gruchot, Ferdinand Lein, Isabel Lewen, Laura Reiche, Vivien Weyers, Patrick Petzsch, Peter Göttle, Karl Köhrer, Hans-Peter Hartung, Patrick Küry, David Kremer. Int J Mol Sci. 2022 Oct 31;23(21):13278. doi: 10.3390/ijms232113278. PubMed

6. Myelin repair is fostered by the corticosteroid medrysone specifically acting on astroglial subpopulations. Markley Silva Oliveira Junior, Jessica Schira-Heinen, Laura Reiche, Seulki Han, Vanessa Cristina Meira de Amorim, Isabel Lewen, Joel Gruchot, Peter Göttle, Rainer Akkermann, Kasum Azim, Patrick Küry. EBioMedicine. 2022 Aug 8;83:104204. doi: 10.1016/j.ebiom.2022.104204. Online ahead of print. PubMed

7. TLR4 Associated Signaling Disrupters as a New Means to Overcome HERV-W Envelope-Mediated Myelination Deficits. Peter Göttle, Kira Schichel, Laura Reiche, Luisa Werner, Annika Zink, Alessandro Prigione, Patrick Küry. Front Cell Neurosci. 2021 Nov 23;15:777542. doi: 10.3389/fncel.2021.777542. eCollection 2021. PubMed

8. C21orf91 Regulates Oligodendroglial Precursor Cell Fate-A Switch in the Glial Lineage? Laura Reiche, Peter Göttle, Lydie Lane, Paula Duek, Mina Park, Kasum Azim, Jana Schütte, Anastasia Manousi, Jessica Schira-Heinen, Patrick Küry. Front Cell Neurosci. 2021 Mar;65:103276. doi: 10.1016/j.ebiom.2021.103276. Epub 2021 Mar 10. PubMed

9. Identification of novel myelin repair drugs by modulation of oligodendroglial differentiation competence. Anastasia Manousi, Peter Göttle, Laura Reiche, Qiao-Ling Cui, Luke M Healy, Rainer Akkermann, Joel Gruchot, Jessica Schira-Heinen, Jack P Antel, Hans-Peter Hartung, Patrick Küry. EBioMedicine. 2021 Mar;65:103276. doi: 10.1016/j.ebiom.2021.103276. Epub 2021 Mar 10. PubMed

10. Heterogeneous fate choice of genetically modulated adult neural stem cells in gray and white matter of the central nervous system. Beyer F, Jadasz J, Samper Agrelo I, Schira-Heinen J, Groh J, Manousi A, Bütermann C, Estrada V, Reiche L, Cantone M, Vera J, Viganò F, Dimou L, Müller HW, Hartung HP, Küry P. Glia. 2020 Feb;68(2):393-406. doi: 10.1002/glia.23724. Epub 2019 Oct 21. PubMed

11. Aberrant Oligodendrogenesis in Down Syndrome: Shift in Gliogenesis? Reiche L, Küry P, Göttle P. Cells. 2019 Dec 7;8(12). pii: E1591. doi: 10.3390/cells8121591. PubMed

12. Teriflunomide promotes oligodendroglial differentiation and myelination. Göttle P, Manousi A, Kremer D, Reiche L, Hartung HP, Küry P. J Neuroinflammation. 2018 Mar 13;15(1):76. doi: 10.1186/s12974-018-1110-z. PubMed

PhD Thesis
Investigation and evaluation of neuroprotective and regenerative strategies in experimental models of Multiple Sclerosis.

Supervisors

• Prof. Dr. Philipp Albrecht
• Prof. Dr. Bodo Levkau

Publications

1. Gruchot J, Lewen I, Dietrich M, Reiche L, Sindi M, Hecker C, Herrero F, Charvet B, Weber-Stadlbauer U, Hartung HP, Albrecht P, Perron H, Meyer U, Küry P. Transgenic expression of the HERV-W envelope protein leads to polarized glial cell populations and a neurodegenerative environment. Proc Natl Acad Sci U S A. 2023 Sep 19;120(38):e2308187120. doi: 10.1073/pnas.2308187120. Epub 2023 Sep 11. PMID: 37695891.

2. Sindi M, Hecker C, Issberner A, Ruck T, Meuth SG, Albrecht P, Dietrich M. S1PR-1/5 modulator RP-101074 shows beneficial effects in a model of central nervous system degeneration. Front Immunol. 2023 Aug 9;14:1234984. doi: 10.3389/fimmu.2023.1234984. PMID: 37638037; PMCID: PMC10450045.

3. Frenger MJ, Hecker C, Sindi M, Issberner A, Hartung HP, Meuth SG, Dietrich M, Albrecht P. Semi-Automated Live Tracking of Microglial Activation in CX3CR1GFP Mice During Experimental Autoimmune Encephalomyelitis by Confocal Scanning Laser Ophthalmoscopy. Front Immunol. 2021 Oct 21;12:761776. doi: 10.3389/fimmu.2021.761776. PMID: 34745138; PMCID: PMC8567040.

4.  Zhang P, Li T, Liu C, Sindi M, Cheng X, Qi S, Liu X, Yan Y, Bao Y, Brand-Saberi B, Yang W, Wang G, Yang X. Nano-sulforaphane attenuates PhIP-induced early abnormal embryonic neuro-development. Ann Anat. 2021 Jan;233:151617. doi: 10.1016/j.aanat.2020.151617. Epub 2020 Oct 21. PMID: 33098981.

PhD Thesis
Ferroptosis in development and diseases.

Supervisors

• PD. Dr. Carsten Berndt
• Prof. Dr. Petra Bauer

Publication:

1. JNK Signalling Regulates Self-Renewal of Proliferative Urine-Derived Renal Progenitor Cells via Inhibition of Ferroptosis. Lisa Nguyen, Leonie Thewes, Michelle Westerhoff, Wasco Wruck, Andreas S Reichert, Carsten Berndt, James Adjaye. Cells. 2023 Sep 2;12(17):2197. doi: 10.3390/cells12172197. PubMed

PhD Thesis
Impact of blood platelets in the progression of Alzheimer´s disease.

Supervisors

• Prof. Dr. Patricia Hidalgo

• Prof. Dr. Margitta Elvers

Publications

1. Impact of Amyloid-β on Platelet Mitochondrial Function and Platelet-Mediated Amyloid Aggregation in Alzheimer's Disease. Lili Donner, Tobias Feige, Carolin Freiburg, Laura Mara Toska, Andreas S Reichert, Madhumita Chatterjee, Margitta Elvers. Int J Mol Sci. 2021 Sep 6;22(17):9633. doi: 10.3390/ijms22179633. PubMed

2. Molecular Drivers of Platelet Activation: Unraveling Novel Targets for Anti-Thrombotic and Anti-Thrombo-Inflammatory Therapy. Madhumita Chatterjee, Agnes Ehrenberg, Laura Mara Toska, Lisa Maria Metz, Meike Klier, Irena Kruege, Friedrich Reusswig, Margitta Elvers. Int J Mol Sci. 2020 Oct 24;21(21):E7906. doi: 10.3390/ijms21217906. PubMed

3. The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of β-amyloid. Lili Donner, Laura Mara Toska, Irena Krüger, Sandra Gröniger, Ruben Barroso, Alice Burleigh, Diego Mezzano, Susanne Pfeiler, Malte Kelm, Norbert Gerdes, Steve P Watson, Yi Sun, Margitta Elvers. Sci Signal. 2020 Aug 4;13(643):eaba9872. doi: 10.1126/scisignal.aba9872. PubMed