PhD Researchers

PhD Thesis
Impact of genotoxins on autophagic processes during neuronal differentiation.

Supervisor

• Prof. Dr. Björn Stork

• Prof. Dr. James Adjaye

• Prof. Dr. Charlotte von Gall

Publications

1. Modulation of Specific Sphingosine-1-Phosphate Receptors Augments a Repair Mediating Schwann Cell Phenotype. Jessica Schira-Heinen, Luzhou Wang, Seda Akgün, Sofia Blum, Brigida Ziegler, André Heinen, Hans-Peter Hartung, Patrick Küry. Int J Mol Sci. 2022 Sep 7;23(18):10311. doi: 10.3390/ijms231810311. PubMed
2. Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells. Yadong Sun, Niklas Berleth, Wenxian Wu, David Schlütermann, Jana Deitersen, Fabian Stuhldreier, Lena Berning, Annabelle Friedrich, Seda Akgün, María José Mendiburo, Sebastian Wesselborg, Marcus Conrad, Carsten Berndt, Björn Stork. Cell Death Dis. 2021 Oct 29;12(11):1028. doi: 10.1038/s41419-021-04306-2. PubMed

PhD Thesis
Unfolding the mechanisms of a cell death type induced under glucose starvation.

Supervisors

• Prof. Dr. Guido Reifenberger

• Prof. Dr. Sebastian Wesselborg

Publication

1. mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism. Tal Levy, Kai Voeltzke, Laura Hruby, Khawla Alasad, Zuelal Bas, Marteinn Snaebjörnsson, Ran Marciano, Katerina Scharov, Mélanie Planque, Kim Vriens, Stefan Christen, Cornelius M Funk, Christina Hassiepen, Alisa Kahler, Beate Heider, Daniel Picard, Jonathan K M Lim, Anja Stefanski, Katja Bendrin, Andres Vargas-Toscano, Ulf D Kahlert, Kai Stühler, Marc Remke, Moshe Elkabets, Thomas G P Grünewald, Andreas S Reichert, Sarah-Maria Fendt, Almut Schulze, Guido Reifenberger, Barak Rotblat, Gabriel Leprivier. Nat Commun. 2024 May 14;15(1):4083. doi: 10.1038/s41467-024-48386-y. PubMed

PhD Thesis
Physiologische Eigenschaften Na+-abhängiger GABA Transporter 

Supervisors

• Prof. Dr. Christine Rose
• Prof. Dr. Dieter WIllbold

PhD Thesis

Molecular mechanisms regulating the differentiation potential of neural stem and progenitor cells upon gamma irradiation.

Supervisors

• Prof. Dr. Christine Rose
• Dr. Christiane Knobbe-Thomsen

PhD Thesis
Neural mechanisms of affective processing, reward and cognition in the context of social behaviour.

Supervisors

• Prof. Dr. Tobias Kalenscher

• Prof. Dr. Carsten Korth

PhD Thesis
Ion homeostasis and acute metabolic inhibition in the murine brain.

Supervisors

• Prof. Dr. Christine Rose
• Prof. Dr. Dieter Willbold

Publications

1. Inward Operation of Sodium-Bicarbonate Cotransporter 1 Promotes Astrocytic Na⁺ Loading and Loss of ATP in Mouse Neocortex during Brief Chemical Ischemia. Katharina Everaerts, Pawan Thapaliya, Nils Pape, Simone Durry, Sara Eitelmann, Eleni Roussa, Ghanim Ullah, Christine R Rose. Cells. 2023 Nov 21;12(23):2675. doi: 10.3390/cells12232675. PubMed
2. Ca²⁺-dependent rapid uncoupling of astrocytes upon brief metabolic stress. Sara Eitelmann, Katharina Everaerts, Laura Petersilie, Christine R Rose, Jonathan Stephan. Front Cell Neurosci. 2023 Oct 11:17:1151608. doi: 10.3389/fncel.2023.1151608. eCollection 2023. PubMed
3. Novel algorithms for improved detection and analysis of fluorescent signal fluctuations. Gebhard Stopper, Laura C Caudal, Phillip Rieder, Davide Gobbo, Laura Stopper, Lisa Felix, Katharina Everaerts, Xianshu Bai, Christine R Rose, Anja Scheller, Frank Kirchhoff. 2023 Nov;475(11):1283-1300. doi: 10.1007/s00424-023-02855-3. Epub 2023 Sep 13. PubMed ID: 37700120 PubMed
4. Cell-Type Dependent Regulation of the Electrogenic Na +/HCO 3- Cotransporter 1 (NBCe1) by Hypoxia and Acidosis in Glioblastoma. Marina Giannaki, Debora E Ruf, Emilie Pfeifer, Katharina Everaerts, Dieter H Heiland, Oliver Schnell, Christine R Rose, Eleni Roussa. Int J Mol Sci. 2022 Aug 11;23(16):8975. doi: 10.3390/ijms23168975. PubMed
5. Changes in Astroglial K + upon Brief Periods of Energy Deprivation in the Mouse Neocortex. Sara Eitelmann, Jonathan Stephan, Katharina Everaerts, Simone Durry, Nils Pape, Niklas J Gerkau, Christine R Rose. Int J Mol Sci. 2022 Apr 27;23(9):4836. doi: 10.3390/ijms23094836. PubMed

PhD Thesis
Ischemia-induced changes of astrocyte and neuron properties

Supervisors

• Prof. Dr. Christine R. Rose

• Prof. Dr. Dieter Willbold

PhD Thesis
Dissecting the neural pathology of Leigh syndrome using patient-derived brain organoids.

Supervisors

• Prof. Dr. Alessandro Prigione
• Prof. Dr. Matias Zurbriggen

Publications

1. Protocol for the generation of cultured cortical brain organoid slices. Laura Petersilie, Karl W Kafitz, Louis A Neu, Sonja Heiduschka, Stephanie Le, Alessandro Prigione, Christine R Rose. STAR Protoc. 2024 Sep 20;5(3):103212.doi: 10.1016/j.xpro.2024.103212. Epub 2024 Aug 10. PubMed
2. Cortical brain organoid slices (cBOS) for the study of human neural cells in minimal networks. Laura Petersilie, Sonja Heiduschka, Joel S E Nelson, Louis A Neu, Stephanie Le, Ruchika Anand, Karl W Kafitz, Alessandro Prigione, Christine R Rose. iScience. 2024 Mar 4;27(4):109415. doi: 10.1016/j.isci.2024.109415. eCollection 2024 Apr 19. PubMed

PhD Thesis
Natural compounds as suppressors of mitochondrial complex I deficiency-associated diseases in mammalian cell models.

Supervisor

• MD, PhD, PD Natascia Ventura

• Prof. Dr. Andreas Reichert

PhD Thesis
Treatment discovery for Leigh syndrome using patient-derived neurons and midbrain organoids 

Supervisors

• Prof. Dr. Alessandro Prigione

• Prof. Dr. Erdem Gültekin Tamgüney

PhD Thesis
Evaluation of relevant factors involved in neurodegeneration, regeneration and demyelination in preclinical models of inflammatory and degenerative CNS disorders using visual system readouts.

Supervisors

• Prof. Dr. Philipp Albrecht

• Prof. Dr. Charlotte von Gall 

PhD Thesis
Hypoxia and sirtuin 1 in neural stem & progenitor cells.

Supervisors

• PD Dr. Carsten Berndt

• Prof. Dr. Andreas Reichert

PhD Thesis
Brain organoids for modelling Leigh syndrome caused by complex I mutations.

Supervisor

• Prof. Dr. Alessandro Prigione

Publications

1. Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure. Pawel Lisowski, Selene Lickfett, Agnieszka Rybak-Wolf, Carmen Menacho, Stephanie Le, Tancredi Massimo Pentimalli, Sofia Notopoulou, Werner Dykstra, Daniel Oehler, Sandra López-Calcerrada, Barbara Mlody, Maximilian Otto, Haijia Wu, Yasmin Richter, Philipp Roth, Ruchika Anand, Linda A M Kulka, David Meierhofer, Petar Glazar, Ivano Legnini, Narasimha Swamy Telugu, Tobias Hahn, Nancy Neuendorf, Duncan C Miller, Annett Böddrich, Amin Polzin, Ertan Mayatepek, Sebastian Diecke, Heidi Olzscha, Janine Kirstein, Cristina Ugalde, Spyros Petrakis, Sidney Cambridge, Nikolaus Rajewsky, Ralf Kühn, Erich E Wanker, Josef Priller, Jakob J Metzger, Alessandro Prigione. Nat Commun. 2024 Aug 22;15(1):7027. doi: 10.1038/s41467-024-51216-w. PubMed
2. Protocol for the generation of cultured cortical brain organoid slices. Laura Petersilie, Karl W Kafitz, Louis A Neu, Sonja Heiduschka, Stephanie Le, Alessandro Prigione, Christine R Rose. STAR Protoc. 2024 Sep 20;5(3):103212.doi: 10.1016/j.xpro.2024.103212. Epub 2024 Aug 10. PubMed
3. Balancing neuronal activity to fight neurodevelopmental disorders. Stephanie Le, Carmen Menacho, Alessandro Prigione. Trends Neurosci. 2024 Apr;47(4):241-242. doi: 10.1016/j.tins.2024.03.002. Epub 2024 Mar 22. PubMed
4. Cortical brain organoid slices (cBOS) for the study of human neural cells in minimal networks. Laura Petersilie, Sonja Heiduschka, Joel S E Nelson, Louis A Neu, Stephanie Le, Ruchika Anand, Karl W Kafitz, Alessandro Prigione, Christine R Rose. iScience. 2024 Mar 4;27(4):109415. doi: 10.1016/j.isci.2024.109415. eCollection 2024 Apr 19. PubMed
5. Activated microglia and neuroinflammation as a pathogenic mechanism in Leigh syndrome. Nastaran Daneshgar, Mariah R Leidinger, Stephanie Le, Marco Hefti, Alessandro Prigione, Dao-Fu Dai. Front Neurosci. 2023 Jan 18;16:1068498. doi: 10.3389/fnins.2022.1068498. eCollection 2022. PubMed

PhD Thesis
Establishment of a glioblastoma model in Drosophila melanogaster as a tool for functional genomics screening

Supervisors

• Prof. Dr. Guido Reifenberger
• Prof. Dr. Thomas Klein

PhD Thesis
Genetic knock-down screenings in human iPSC-derived neurons.

Supervisor

• Prof. Dr. Alessandro Prigione

• Dr. Sidney Cambridge

Publications

1. Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure. Pawel Lisowski, Selene Lickfett, Agnieszka Rybak-Wolf, Carmen Menacho, Stephanie Le, Tancredi Massimo Pentimalli, Sofia Notopoulou, Werner Dykstra, Daniel Oehler, Sandra López-Calcerrada, Barbara Mlody, Maximilian Otto, Haijia Wu, Yasmin Richter, Philipp Roth, Ruchika Anand, Linda A M Kulka, David Meierhofer, Petar Glazar, Ivano Legnini, Narasimha Swamy Telugu, Tobias Hahn, Nancy Neuendorf, Duncan C Miller, Annett Böddrich, Amin Polzin, Ertan Mayatepek, Sebastian Diecke, Heidi Olzscha, Janine Kirstein, Cristina Ugalde, Spyros Petrakis, Sidney Cambridge, Nikolaus Rajewsky, Ralf Kühn, Erich E Wanker, Josef Priller, Jakob J Metzger, Alessandro Prigione. Nat Commun. 2024 Aug 22;15(1):7027. doi: 10.1038/s41467-024-51216-w. PubMed

2. High-content analysis of neuronal morphology in human iPSC-derived neurons. Selene Lickfett, Carmen Menacho, Annika Zink, Narasimha Swamy Telugu, Mathias Beller, Sebastian Diecke, Sidney Cambridge, Alessandro Prigione. STAR Protoc. 2022 Aug 6;3(3):101567. doi: 10.1016/j.xpro.2022.101567. eCollection 2022 Sep 16. PubMed

3. A call for consensus guidelines on monitoring the integrity of nuclear and mitochondrial genomes in human pluripotent stem cells. Andrea Rossi, Selene Lickfett, Soraia Martins, Alessandro Prigione. Stem Cell Reports. 2022 Apr 12;17(4):707-710.doi: 10.1016/j.stemcr.2022.01.019. Epub 2022 Mar 3. PubMed

PhD Thesis
Unraveling glucose starvation-induced cell death: from the impact on ion homeostasis to the pathological relevance. 

Supervisors

• Prof. Dr. Guido Reifenberger

• Prof. Dr. Christine Rose

Publications

PhD Thesis
Revealing the pathological mechanism of neural impairment of Leigh syndrome using engineered patient-derived neural cells.

Supervisor

• Prof. Dr. Alessandro Prigione

Publications

1. Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure. Pawel Lisowski, Selene Lickfett, Agnieszka Rybak-Wolf, Carmen Menacho, Stephanie Le, Tancredi Massimo Pentimalli, Sofia Notopoulou, Werner Dykstra, Daniel Oehler, Sandra López-Calcerrada, Barbara Mlody, Maximilian Otto, Haijia Wu, Yasmin Richter, Philipp Roth, Ruchika Anand, Linda A M Kulka, David Meierhofer, Petar Glazar, Ivano Legnini, Narasimha Swamy Telugu, Tobias Hahn, Nancy Neuendorf, Duncan C Miller, Annett Böddrich, Amin Polzin, Ertan Mayatepek, Sebastian Diecke, Heidi Olzscha, Janine Kirstein, Cristina Ugalde, Spyros Petrakis, Sidney Cambridge, Nikolaus Rajewsky, Ralf Kühn, Erich E Wanker, Josef Priller, Jakob J Metzger, Alessandro Prigione. Nat Commun. 2024 Aug 22;15(1):7027. doi: 10.1038/s41467-024-51216-w. PubMed
2. Balancing neuronal activity to fight neurodevelopmental disorders. Stephanie Le, Carmen Menacho, Alessandro Prigione. Trends Neurosci. 2024 Apr;47(4):241-242. doi: 10.1016/j.tins.2024.03.002. Epub 2024 Mar 22. PubMed
3. High-content analysis of neuronal morphology in human iPSC-derived neurons. Selene Lickfett, Carmen Menacho, Annika Zink, Narasimha Swamy Telugu, Mathias Beller, Sebastian Diecke, Sidney Cambridge, Alessandro Prigione. STAR Protoc. 2022 Aug 6;3(3):101567. doi: 10.1016/j.xpro.2022.101567. eCollection 2022 Sep 16. PubMed
4. Generation of Human Brain Organoids for Mitochondrial Disease Modeling. Le S, Petersilie L, Inak G, Menacho-Pando C, Kafitz KW, Rybak-Wolf A, Rajewsky N, Rose CR, Prigione A. J Vis Exp. 2021 Jun 21;(172). doi: 10.3791/62756. PubMed

PhD Thesis
Expression of genetically encoded biosensors for the functional characterization of murine and human brain tissue

Supervisors

• Prof. Dr. Christine R. Rose

Co-Supervisor

• Prof. Dr. Alessandro Prigione

Publications

1. Deep-Learning-Based Segmentation of Cells and Analysis (DL-SCAN). Alok Bhattarai, Jan Meyer, Laura Petersilie, Syed I Shah, Louis A Neu, Christine R Rose, Ghanim Ullah. Biomolecules. 2024 Oct 23;14(11):1348. doi: 10.3390/biom14111348. PubMed
2. Protocol for the generation of cultured cortical brain organoid slices. Laura Petersilie, Karl W Kafitz, Louis A Neu, Sonja Heiduschka, Stephanie Le, Alessandro Prigione, Christine R Rose. STAR Protoc. 2024 Sep 20;5(3):103212.doi: 10.1016/j.xpro.2024.103212. Epub 2024 Aug 10. PubMed
3. Cortical brain organoid slices (cBOS) for the study of human neural cells in minimal networks. Laura Petersilie, Sonja Heiduschka, Joel S E Nelson, Louis A Neu, Stephanie Le, Ruchika Anand, Karl W Kafitz, Alessandro Prigione, Christine R Rose. iScience. 2024 Mar 4;27(4):109415. doi: 10.1016/j.isci.2024.109415. eCollection 2024 Apr 19. PubMed

PhD Thesis
C21orf91 as a novel modulator of glial cell determination and differentiation.

Supervisors

• Prof. Dr. Patrick Küry

• Prof. Dr. Christine R. Rose

Publications

1. HERV-W envelope protein is present in microglial cells of the human glioma tumor microenvironment and differentially modulates neoplastic cell behavior. Laura Reiche, Benedikt Plaack, Maike Lehmkuhl, Vivien Weyers, Joel Gruchot, Daniel Picard, Hervé Perron, Marc Remke, Christiane Knobbe-Thomsen, Guido Reifenberger, Patrick Küry, David Kremer. Microbes Infect. 2024 Nov 20:105460. doi: 10.1016/j.micinf.2024.105460. Online ahead of print. PubMed

2. Molecular dissection of HERV-W dependent microglial- and astroglial cell polarization. Joel Gruchot, Laura Reiche, Luisa Werner, Felisa Herrero, Jessica Schira-Heinen, Urs Meyer, Patrick Küry. Microbes Infect. 2024 Jun 27:105382. doi: 10.1016/j.micinf.2024.105382. Online ahead of print. PubMed

3. Human endogenous retrovirus type-W and multiple sclerosis-related smoldering neuroinflammation. Joel Gruchot, Laura Reiche, Andrew Chan, Robert Hoepner, Patrick Küry. Neural Regen Res. 2025 Mar 1;20(3):813-814. doi: 10.4103/NRR.NRR-D-24-00121. Epub 2024 May 13. PubMed

4. Star power: harnessing the reactive astrocyte response to promote remyelination in multiple sclerosis. Markley Silva Oliveira Junior, Laura Reiche, Emerson Daniele, Ines Kortebi, Maryam Faiz, Patrick Küry. Neural Regen Res. 2024 Mar;19(3):578-582. doi: 10.4103/1673-5374.380879. PubMed

5. Transgenic expression of the HERV-W envelope protein leads to polarized glial cell populations and a neurodegenerative environment. Joel Gruchot, Isabel Lewen, Michael Dietrich, Laura Reiche, Mustafa Sindi, Christina Hecker, Felisa Herrero, Benjamin Charvet, Ulrike Weber-Stadlbauer, Hans-Peter Hartung, Philipp Albrecht, Hervé Perron, Urs Meyer, Patrick Küry. Proc Natl Acad Sci U S A. 2023 Sep 19;120(38):e2308187120. doi: 10.1073/pnas.2308187120. Epub 2023 Sep 11. PubMed

6. A Novel Ex Vivo Model to Study Therapeutic Treatments for Myelin Repair following Ischemic Damage. Luisa Werner, Michael Gliem, Nicole Rychlik, Goran Pavic, Laura Reiche, Frank Kirchhoff, Markley Silva Oliveira Junior, Joel Gruchot, Sven G Meuth, Patrick Küry, Peter Göttle. Int J Mol Sci. 2023 Jun 30;24(13):10972. doi: 10.3390/ijms241310972. PubMed

7. Teriflunomide as a therapeutic means for myelin repair. Peter Göttle, Janos Groh, Laura Reiche, Joel Gruchot, Nicole Rychlik, Luisa Werner, Iria Samper Agrelo, Rainer Akkermann, Annika Zink, Alessandro Prigione, Hans-Peter Hartung, Rudolf Martini, Patrick Küry. J Neuroinflammation. 2023 Jan 7;20(1):7. doi: 10.1186/s12974-022-02686-6. PubMed

8. Siponimod Modulates the Reaction of Microglial Cells to Pro-Inflammatory Stimulation. Joel Gruchot, Ferdinand Lein, Isabel Lewen, Laura Reiche, Vivien Weyers, Patrick Petzsch, Peter Göttle, Karl Köhrer, Hans-Peter Hartung, Patrick Küry, David Kremer. Int J Mol Sci. 2022 Oct 31;23(21):13278. doi: 10.3390/ijms232113278. PubMed

9. Myelin repair is fostered by the corticosteroid medrysone specifically acting on astroglial subpopulations. Markley Silva Oliveira Junior, Jessica Schira-Heinen, Laura Reiche, Seulki Han, Vanessa Cristina Meira de Amorim, Isabel Lewen, Joel Gruchot, Peter Göttle, Rainer Akkermann, Kasum Azim, Patrick Küry. EBioMedicine. 2022 Aug 8;83:104204. doi: 10.1016/j.ebiom.2022.104204. Online ahead of print. PubMed

10. TLR4 Associated Signaling Disrupters as a New Means to Overcome HERV-W Envelope-Mediated Myelination Deficits. Peter Göttle, Kira Schichel, Laura Reiche, Luisa Werner, Annika Zink, Alessandro Prigione, Patrick Küry. Front Cell Neurosci. 2021 Nov 23;15:777542. doi: 10.3389/fncel.2021.777542. eCollection 2021. PubMed

11. C21orf91 Regulates Oligodendroglial Precursor Cell Fate-A Switch in the Glial Lineage? Laura Reiche, Peter Göttle, Lydie Lane, Paula Duek, Mina Park, Kasum Azim, Jana Schütte, Anastasia Manousi, Jessica Schira-Heinen, Patrick Küry. Front Cell Neurosci. 2021 Mar;65:103276. doi: 10.1016/j.ebiom.2021.103276. Epub 2021 Mar 10. PubMed

12. Identification of novel myelin repair drugs by modulation of oligodendroglial differentiation competence. Anastasia Manousi, Peter Göttle, Laura Reiche, Qiao-Ling Cui, Luke M Healy, Rainer Akkermann, Joel Gruchot, Jessica Schira-Heinen, Jack P Antel, Hans-Peter Hartung, Patrick Küry. EBioMedicine. 2021 Mar;65:103276. doi: 10.1016/j.ebiom.2021.103276. Epub 2021 Mar 10. PubMed

13. Heterogeneous fate choice of genetically modulated adult neural stem cells in gray and white matter of the central nervous system. Beyer F, Jadasz J, Samper Agrelo I, Schira-Heinen J, Groh J, Manousi A, Bütermann C, Estrada V, Reiche L, Cantone M, Vera J, Viganò F, Dimou L, Müller HW, Hartung HP, Küry P. Glia. 2020 Feb;68(2):393-406. doi: 10.1002/glia.23724. Epub 2019 Oct 21. PubMed

14. Aberrant Oligodendrogenesis in Down Syndrome: Shift in Gliogenesis? Reiche L, Küry P, Göttle P. Cells. 2019 Dec 7;8(12). pii: E1591. doi: 10.3390/cells8121591. PubMed

15. Teriflunomide promotes oligodendroglial differentiation and myelination. Göttle P, Manousi A, Kremer D, Reiche L, Hartung HP, Küry P. J Neuroinflammation. 2018 Mar 13;15(1):76. doi: 10.1186/s12974-018-1110-z. PubMed

PhD Thesis
Investigation and evaluation of neuroprotective and regenerative strategies in experimental models of Multiple Sclerosis.

Supervisors

• Prof. Dr. Philipp Albrecht
• Prof. Dr. Bodo Levkau

Publications

1. Gruchot J, Lewen I, Dietrich M, Reiche L, Sindi M, Hecker C, Herrero F, Charvet B, Weber-Stadlbauer U, Hartung HP, Albrecht P, Perron H, Meyer U, Küry P. Transgenic expression of the HERV-W envelope protein leads to polarized glial cell populations and a neurodegenerative environment. Proc Natl Acad Sci U S A. 2023 Sep 19;120(38):e2308187120. doi: 10.1073/pnas.2308187120. Epub 2023 Sep 11. PMID: 37695891.

2. Sindi M, Hecker C, Issberner A, Ruck T, Meuth SG, Albrecht P, Dietrich M. S1PR-1/5 modulator RP-101074 shows beneficial effects in a model of central nervous system degeneration. Front Immunol. 2023 Aug 9;14:1234984. doi: 10.3389/fimmu.2023.1234984. PMID: 37638037; PMCID: PMC10450045.

3. Frenger MJ, Hecker C, Sindi M, Issberner A, Hartung HP, Meuth SG, Dietrich M, Albrecht P. Semi-Automated Live Tracking of Microglial Activation in CX3CR1GFP Mice During Experimental Autoimmune Encephalomyelitis by Confocal Scanning Laser Ophthalmoscopy. Front Immunol. 2021 Oct 21;12:761776. doi: 10.3389/fimmu.2021.761776. PMID: 34745138; PMCID: PMC8567040.

4.  Zhang P, Li T, Liu C, Sindi M, Cheng X, Qi S, Liu X, Yan Y, Bao Y, Brand-Saberi B, Yang W, Wang G, Yang X. Nano-sulforaphane attenuates PhIP-induced early abnormal embryonic neuro-development. Ann Anat. 2021 Jan;233:151617. doi: 10.1016/j.aanat.2020.151617. Epub 2020 Oct 21. PMID: 33098981.

PhD Thesis
Investigating oncogene signaling-mediated glycoproteome remodeling

Supervisors

• Prof. Dr. Guido Reifenberger

• Prof. Dr. Lutz Schmitt

Publications

• Oncogenic RAS signaling suppresses ferroptosis via transcriptional upregulation of GCH1, Jonathan K. M. Lim, Frauke Stölting, Tal Levy, Leonie Thewes, Daniel Picard, Sofya Tishina, Hai-Feng Zhang, Oksana Lewandowska, Tobias Reiff, Marc Remke, Johannes Brägelmann, Filippo Beleggia, Carsten Berndt, Silvia von Karstedt, Guido Reifenberger, Barak Rotblat, Gabriel Leprivier, bioRxiv, January 29, 2024, doi: doi.org/10.1101/2024.01.27.577524, this article is a preprint and has not been certified by peer review.
• Early life adversity drives sex-specific anhedonia and meningeal immune gene expression through mast cell activation, Natalia Duque-Wilckens, Robert Teis, Erika Sarno, Frauke Stoelting, Sonia Khalid, Zakaria Dairi, Alex Douma, Nidia Maradiaga, Stina Hench, Christine D Dharshika, Kyan M Thelen, Brian Gulbransen, A J Robison, Adam J Moeser, Brain Behav Immun. 2022 Jul;103:73-84. doi: 10.1016/j.bbi.2022.03.009. Epub 2022 Mar 24. PMID: 35339629; PMCID: PMC9149134.
• WBP2-Onkogen-Regulation durch miRNA-prozessierenden Dicer im Hippo/MST-Signalweg, Frauke Stoelting, Journal Club, March 2021, BIOspektrum 27(2):172-175, DOI:10.1007/s12268-021-1552-1
• The histamine H3R and dopamine D2R/D3R antagonist ST-713 ameliorates autism-like behavioral features in BTBR T+tf/J mice by multiple actions, Karthikkumar Venkatachalam, Nermin Eissa, Mohamed Al Awad, Petrilla Jayaprakash, Sicheng Zhong, Frauke Stölting, Holger Stark, Bassem Sadek, Biomedicine & Pharmacotherapy, Volume 138, 2021, 111517, ISSN 0753-3322, DOI: doi.org/10.1016/j.biopha.2021.111517.

PhD Thesis
Ferroptosis in development and diseases.

Supervisors

• PD. Dr. Carsten Berndt
• Prof. Dr. Petra Bauer

Publications:

1. Ferroptosis in health and disease. Carsten Berndt, Hamed Alborzinia, Vera Skafar Amen, Scott Ayton, Uladzimir Barayeu, Alexander Bartelt, Hülya Bayir, Christina M Bebber, Kivanc Birsoy, Jan P Böttcher, Simone Brabletz, Thomas Brabletz, Ashley R Brown, Bernhard Brüne, Giorgia Bulli, Alix Bruneau, Quan Chen, Gina M DeNicola, Tobias P Dick, Ayelén Distéfano, Scott J Dixon, Jan B Engler, Julia Esser-von Bieren, Maria Fedorova, José Pedro Friedmann Angeli, Manuel A Friese, Dominic C Fuhrmann, Ana J García-Sáez, Karolina Garbowicz, Magdalena Götz, Wei Gu, Linda Hammerich, Behrouz Hassannia, Xuejun Jiang, Aicha Jeridi, Yun Pyo Kang, Valerian E Kagan, David B Konrad, Stefan Kotschi, Peng Lei, Marlène Le Tertre, Sima Lev, Deguang Liang, Andreas Linkermann, Carolin Lohr, Svenja Lorenz, Tom Luedde, Axel Methner, Bernhard Michalke, Anna V Milton, Junxia Min, Eikan Mishima, Sebastian Müller, Hozumi Motohashi, Martina U Muckenthaler, Shohei Murakami, James A Olzmann, Gabriela Pagnussat, Zijan Pan, Thales Papagiannakopoulos, Lohans Pedrera Puentes, Derek A Pratt, Bettina Proneth, Lukas Ramsauer, Raphael Rodriguez, Yoshiro Saito, Felix Schmidt, Carina Schmitt, Almut Schulze, Annemarie Schwab, Anna Schwantes, Mariluz Soula, Benedikt Spitzlberger, Brent R Stockwell, Leonie Thewes, Oliver Thorn-Seshold, Shinya Toyokuni, Wulf Tonnus, Andreas Trumpp, Peter Vandenabeele, Tom Vanden Berghe, Vivek Venkataramani, Felix C E Vogel, Silvia von Karstedt, Fudi Wang, Frank Westermann, Chantal Wientjens, Christoph Wilhelm, Michele Wölk, Katherine Wu, Xin Yang, Fan Yu, Yilong Zou, Marcus Conrad. Redox Biol. 2024 Sep:75:103211.doi: 10.1016/j.redox.2024.103211. Epub 2024 May 30. PubMed
2. JNK Signalling Regulates Self-Renewal of Proliferative Urine-Derived Renal Progenitor Cells via Inhibition of Ferroptosis. Lisa Nguyen, Leonie Thewes, Michelle Westerhoff, Wasco Wruck, Andreas S Reichert, Carsten Berndt, James Adjaye. Cells. 2023 Sep 2;12(17):2197. doi: 10.3390/cells12172197. PubMed

PhD Thesis
Pharmacological promotion of CNS regeneration following neurodegenerative diseases via specific SP1R modulation.

Supervisors

• Prof. Dr. Patrick Küry

• Prof. Dr. Simone Prömel

Publications:

1. Molecular dissection of HERV-W dependent microglial- and astroglial cell polarization. Joel Gruchot, Laura Reiche, Luisa Werner, Felisa Herrero, Jessica Schira-Heinen, Urs Meyer, Patrick Küry. Microbes Infect. 2024 Jun 27:105382. doi: 10.1016/j.micinf.2024.105382. Online ahead of print. PubMed
2. A Novel Ex Vivo Model to Study Therapeutic Treatments for Myelin Repair following Ischemic Damage. Luisa Werner, Michael Gliem, Nicole Rychlik, Goran Pavic, Laura Reiche, Frank Kirchhoff, Markley Silva Oliveira Junior, Joel Gruchot, Sven G Meuth, Patrick Küry, Peter Göttle. Int J Mol Sci. 2023 Jun 30;24(13):10972. doi: 10.3390/ijms241310972. PubMed
3. Teriflunomide as a therapeutic means for myelin repair. Peter Göttle, Janos Groh, Laura Reiche, Joel Gruchot, Nicole Rychlik, Luisa Werner, Iria Samper Agrelo, Rainer Akkermann, Annika Zink, Alessandro Prigione, Hans-Peter Hartung, Rudolf Martini, Patrick Küry. J Neuroinflammation. 2023 Jan 7;20(1):7. doi: 10.1186/s12974-022-02686-6. PubMed
4. TLR4 Associated Signaling Disrupters as a New Means to Overcome HERV-W Envelope-Mediated Myelination Deficits. Peter Göttle, Kira Schichel, Laura Reiche, Luisa Werner, Annika Zink, Alessandro Prigione, Patrick Küry. Front Cell Neurosci. 2021 Nov 23:15:777542. doi: 10.3389/fncel.2021.777542. eCollection 2021. PubMed