Jump to contentJump to search
Neurone im Raum mit iBrain Logo

PhD Researchers

Seda Akgün
Institute for Molecular Medicine I
Heinrich-Heine-University
40225 Düsseldorf

PhD Thesis
Impact of genotoxins on autophagic processes during neuronal differentiation.

Supervisor

Publication

  1. Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells. Yadong Sun, Niklas Berleth, Wenxian Wu, David Schlütermann, Jana Deitersen, Fabian Stuhldreier, Lena Berning, Annabelle Friedrich, Seda Akgün, María José Mendiburo, Sebastian Wesselborg, Marcus Conrad, Carsten Berndt, Björn Stork. Cell Death Dis. 2021 Oct 29;12(11):1028. doi: 10.1038/s41419-021-04306-2. PubMed

Janine Ciftcioglu
Institute of Neuropathology
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf

PhD Thesis

Molecular mechanisms regulating the differentiation potential of neural stem and progenitor cells upon gamma irradiation.

Supervisors

Foto von

Alexandra Dybala (née Ziemski)
Institute for Physical Biology
Heinrich-Heine-University Düsseldorf 40225 Düsseldorf

Scholarship holder of the Christiane and Claudia Hempel-Foundation for stem cell research

PhD Thesis
Blood-Based Single Particle Analysis for Diagnosis of Alzheimer‘s Disease.

Supervisors

Co-Supervisor:

  • Dr. Oliver Bannach

Publication

  1. Oral and intravenous transmission of α-synuclein fibrils to mice. Lohmann S, Bernis ME, Tachu BJ, Ziemski A, Grigoletto J, Tamgüney G. Acta Neuropathol. 2019 Oct;138(4):515-533. doi: 10.1007/s00401-019-02037-5. Epub 2019 Jun 22. PMID: 31230104 PubMed

Foto von

Sara Eitelmann
Institute of Neurobiology
Heinrich-Heine-University Düsseldorf 40225 Düsseldorf

PhD Thesis
Gap junctional coupling under ischemic conditions.

Supervisors

Publications

  1. Approaches to Study Gap Junctional Coupling. Stephan J, Eitelmann S, Zhou M. Front Cell Neurosci. 2021 Mar 10;15:640406. doi: 10.3389/fncel.2021.640406. eCollection 2021. PubMed
  2. Altered Gap Junction Network Topography in Mouse Models for Human Hereditary Deafness. Sara Eitelmann, Laura Petersilie, Christine R Rose, Jonathan Stephan. Int J Mol Sci. 2020 Oct 6;21(19):7376. doi: 10.3390/ijms21197376. PubMed
  3. A Vector-Based Method to Analyze the Topography of Glial Networks. Sara Eitelmann, Jan J Hirtz, Jonathan Stephan. Int J Mol Sci. 2019 Jun 10;20(11):2821. doi: 10.3390/ijms20112821. PubMed

Katharina Everaerts
Institute of Neurobiology
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf

PhD Thesis
Ion homeostasis and acute metabolic inhibition in the murine brain.

Supervisors

Joel Gruchot
Dept. of Neurology - Neuroregeneration
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf

PhD Thesis
Modulation of interactions between microglial cells and myelinated axons in response to the HERV-W envelope protein.

Supervisors

Publications

  1. Translational value of choroid plexus imaging for tracking neuroinflammation in mice and humans. Vinzenz Fleischer, Gabriel Gonzalez-Escamilla, Dumitru Ciolac, Philipp Albrecht, Patrick Küry, Joel Gruchot, Michael Dietrich, Christina Hecker, Thomas Müntefering, Stefanie Bock, Mohammadsaleh Oshaghi, Angela Radetz, Manuela Cerina, Julia Krämer, Lydia Wachsmuth, Cornelius Faber, Hans Lassmann, Tobias Ruck, Sven G Meuth, Muthuraman Muthuraman, Sergiu Groppa. Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2025000118. doi: 10.1073/pnas.2025000118. PubMed

  2. Identification of novel myelin repair drugs by modulation of oligodendroglial differentiation competence. Anastasia Manousi, Peter Göttle, Laura Reiche, Qiao-Ling Cui, Luke M Healy, Rainer Akkermann, Joel Gruchot, Jessica Schira-Heinen, Jack P Antel, Hans-Peter Hartung, Patrick Küry. EBioMedicine. 2021 Mar;65:103276. doi: 10.1016/j.ebiom.2021.103276. Epub 2021 Mar 10. PubMed

  3. Meeting report: "Human endogenous retroviruses: HERVs or transposable elements in autoimmune, chronic inflammatory and degenerative diseases or cancer", Lyon, France, november 5th and 6th 2019 - an MS scientist's digest. Kremer D, Weyers V, Gruchot J, Göttle P, Hartung HP, Perron H, Küry P. Mult Scler Relat Disord. 2020 Jul;42:102068. doi: 10.1016/j.msard.2020.102068. Epub 2020 Apr 8. PubMed

  4. Human endogenous retroviruses: ammunition for myeloid cells in neurodegenerative diseases? Gruchot J, Kremer D, Küry P. Neural Regen Res. 2020 Jun;15(6):1043-1044. doi: 10.4103/1673-5374.270311. PubMed

  5. The Molecular Basis for Remyelination Failure in Multiple Sclerosis. Gruchot J, Weyers V, Göttle P, Förster M, Hartung HP, Küry P, Kremer D. Cells. 2019 Aug 3;8(8):825. doi: 10.3390/cells8080825. PubMed

  6. Neural Cell Responses Upon Exposure to Human Endogenous Retroviruses. Gruchot J, Kremer D, Küry P. Front Genet. 2019 Jul 11;10:655. doi: 10.3389/fgene.2019.00655. eCollection 2019. PubMed

  7. pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis. Kremer D, Gruchot J, Weyers V, Oldemeier L, Göttle P, Healy L, Ho Jang J, Kang T Xu Y, Volsko C, Dutta R, Trapp BD, Perron H, Hartung HP, Küry P. Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):15216-15225. doi: 10.1073/pnas.1901283116. Epub 2019 Jun 18. PubMed

  8. Rescuing the negative impact of human endogenous retrovirus envelope protein on oligodendroglial differentiation and myelination. Göttle P, Förster M, Gruchot J, Kremer D, Hartung HP, Perron H, Küry P. Glia. 2019 Jan;67(1):160-170. doi: 10.1002/glia.23535. Epub 2018 Nov 14. PubMed

Christian Kroll
Dept. of Neurology - Molecular Neurology
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf

PhD Thesis
Hypoxia and sirtuin 1 in neural stem & progenitor cells.

Supervisors

Dang Tri Le
Cell Biology
Leibniz Research Institute for Environmental Medicine
40225 Düsseldorf

PhD Thesis
Life span-resolved nanotoxicology: amyloid aggregation, neuronal targets and vulnerable age-groups in the nematode Caenorhabditis elegans.

Supervisors

Selene Lickfett
Department of General Pediatrics
University Children’s Hospital
Stem Cell Metabolism
Heinrich-Heine-University
40225 Düsseldorf

PhD Thesis
Genetic knock-down screenings in human iPSC-derived neurons.

Supervisor

Carmen Maria Menacho Pando
Department of General Pediatrics
University Children’s Hospital
Stem Cell Metabolism
Heinrich-Heine-University
40225 Düsseldorf

PhD Thesis
Revealing the pathological mechanism of neural impairment of Leigh syndrome using engineered patient-derived neural cells.

Supervisor

Publication

  1. Generation of Human Brain Organoids for Mitochondrial Disease Modeling. Le S, Petersilie L, Inak G, Menacho-Pando C, Kafitz KW, Rybak-Wolf A, Rajewsky N, Rose CR, Prigione A. J Vis Exp. 2021 Jun 21;(172). doi: 10.3791/62756. PubMed
Foto von

Nils Pape
Institute of Neurobiology
Heinrich-Heine-University Düsseldorf 40225 Düsseldorf

PhD Thesis
Effects of energy deprivation on cellular ion homeostasis in the mouse brain.

Supervisors

Foto von

Laura Petersilie
Institute of Neurobiology
Heinrich-Heine-University Düsseldorf 40225 Düsseldorf

PhD Thesis
Influence of metabolic inhibition on the ion homeostasis of brain cells.

Supervisors

Publications

  1. Glial Chloride Homeostasis Under Transient Ischemic Stress. Miriam Engels, Manu Kalia, Sarah Rahmati, Laura Petersilie, Peter Kovermann, Michel J A M van Putten, Christine R Rose, Hil G E Meijer, Thomas Gensch, Christoph Fahlke. Front Cell Neurosci. 2021 Sep 16;15:735300. doi: 10.3389/fncel.2021.735300. eCollection 2021. PubMed

  2. Human Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Produce Distinct Neural 3D In Vitro Models Depending on Alginate/Gellan Gum/Laminin Hydrogel Blend Properties. Kapr J, Petersilie L, Distler T, Lauria I, Bendt F, Sauter CM, Boccaccini AR, Rose CR, Fritsche E. Adv Healthc Mater. 2021 Aug;10(16):e2100131. doi: 10.1002/adhm.202100131. Epub 2021 Jul 1. PubMed

  3. Generation of Human Brain Organoids for Mitochondrial Disease Modeling. Le S, Petersilie L, Inak G, Menacho-Pando C, Kafitz KW, Rybak-Wolf A, Rajewsky N, Rose CR, Prigione A. J Vis Exp. 2021 Jun 21;(172). doi: 10.3791/62756. PubMed

  4. Altered Gap Junction Network Topography in Mouse Models for Human Hereditary Deafness. Sara Eitelmann, Laura Petersilie, Christine R Rose, Jonathan Stephan. Int J Mol Sci. 2020 Oct 6;21(19):7376. doi: 10.3390/ijms21197376. PubMed

Foto von

Laura Reiche
Dept. of Neurology - Neuroregeneration
Heinrich-Heine-University Düsseldorf 40225 Düsseldorf

PhD Thesis
C21orf91 as a novel modulator of glial cell determination and differentiation.

Supervisors

Publications

  1. C21orf91 Regulates Oligodendroglial Precursor Cell Fate-A Switch in the Glial Lineage? Laura Reiche, Peter Göttle, Lydie Lane, Paula Duek, Mina Park, Kasum Azim, Jana Schütte, Anastasia Manousi, Jessica Schira-Heinen, Patrick Küry. Front Cell Neurosci. 2021 Mar;65:103276. doi: 10.1016/j.ebiom.2021.103276. Epub 2021 Mar 10.. PubMed

  2. Identification of novel myelin repair drugs by modulation of oligodendroglial differentiation competence. Anastasia Manousi, Peter Göttle, Laura Reiche, Qiao-Ling Cui, Luke M Healy, Rainer Akkermann, Joel Gruchot, Jessica Schira-Heinen, Jack P Antel, Hans-Peter Hartung, Patrick Küry. EBioMedicine. 2021 Mar;65:103276. doi: 10.1016/j.ebiom.2021.103276. Epub 2021 Mar 10. PubMed

  3. Heterogeneous fate choice of genetically modulated adult neural stem cells in gray and white matter of the central nervous system. Beyer F, Jadasz J, Samper Agrelo I, Schira-Heinen J, Groh J, Manousi A, Bütermann C, Estrada V, Reiche L, Cantone M, Vera J, Viganò F, Dimou L, Müller HW, Hartung HP, Küry P. Glia. 2020 Feb;68(2):393-406. doi: 10.1002/glia.23724. Epub 2019 Oct 21. PubMed

  4. Aberrant Oligodendrogenesis in Down Syndrome: Shift in Gliogenesis? Reiche L, Küry P, Göttle P. Cells. 2019 Dec 7;8(12). pii: E1591. doi: 10.3390/cells8121591. PubMed

  5. Teriflunomide promotes oligodendroglial differentiation and myelination. Göttle P, Manousi A, Kremer D, Reiche L, Hartung HP, Küry P. J Neuroinflammation. 2018 Mar 13;15(1):76. doi: 10.1186/s12974-018-1110-z. PubMed

Markley Silva Oliveira Junior
Dept. of Neurology - Neuroregeneration
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf

PhD Thesis
Stimulating transcriptional networks of forebrain neural stem cells using in silico discovery approaches for regeneration in demyelinating diseases.

Supervisors

Foto von

Mustafa Sindi
Dept. of Neurology
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf

PhD Thesis
Investigation and evaluation of neuroprotective and regenerative strategies in experimental models of Multiple Sclerosis.

Supervisors

  • Prof. Dr. Philipp Albrecht
  • Prof. Dr. Bodo Levkau

Publication

  1. Semi-Automated Live Tracking of Microglial Activation in CX3CR1GFP Mice During Experimental Autoimmune Encephalomyelitis by Confocal Scanning Laser Ophthalmoscopy. Frenger, M. J., Hecker, C., Sindi, M., Issberner, A., Hartung, H.-P., Meuth, S. G., Dietrich, M., & Albrecht, P. Front. Immunol., 21 October 2021; 12, 4449. doi.org/10.3389/fimmu.2021.761776
  2. Nano-sulforaphane attenuates PhIP-induced early abnormal embryonic neuro-development. Zhang P, Li T, Liu C, Sindi M, Cheng X, Qi S, Liu X, Yan Y, Bao Y, Brand-Saberi B, Yang W, Wang G, Yang X.  Ann Anat. 2021 Jan;233:151617. doi: 10.1016/j.aanat.2020.151617. Epub 2020 Oct 21. PubMed
Foto von

Laura Mara Toska
Dept. of Vascular and Endovascular Surgery
Heinrich-Heine-University Düsseldorf 40225 Düsseldorf

PhD Thesis
Impact of blood platelets in the progression of Alzheimer´s disease.

Supervisors

  • Prof. Dr. Patricia Hidalgo

  • Prof. Dr. Margitta Elvers

Publications

  1. Impact of Amyloid-β on Platelet Mitochondrial Function and Platelet-Mediated Amyloid Aggregation in Alzheimer's Disease. Lili Donner, Tobias Feige, Carolin Freiburg, Laura Mara Toska, Andreas S Reichert, Madhumita Chatterjee, Margitta Elvers. Int J Mol Sci. 2021 Sep 6;22(17):9633. doi: 10.3390/ijms22179633. PubMed

  2. Molecular Drivers of Platelet Activation: Unraveling Novel Targets for Anti-Thrombotic and Anti-Thrombo-Inflammatory Therapy. Madhumita Chatterjee, Agnes Ehrenberg, Laura Mara Toska, Lisa Maria Metz, Meike Klier, Irena Kruege, Friedrich Reusswig, Margitta Elvers. Int J Mol Sci. 2020 Oct 24;21(21):E7906. doi: 10.3390/ijms21217906. PubMed

  3. The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of β-amyloid. Lili Donner, Laura Mara Toska, Irena Krüger, Sandra Gröniger, Ruben Barroso, Alice Burleigh, Diego Mezzano, Susanne Pfeiler, Malte Kelm, Norbert Gerdes, Steve P Watson, Yi Sun, Margitta Elvers. Sci Signal. 2020 Aug 4;13(643):eaba9872. doi: 10.1126/scisignal.aba9872. PubMed

Else van Gerresheim
Institute of Neuropathology
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf

PhD Thesis
Abeta prion spreading: Correlation with behavior and prion protein cofactor.

Supervisor

Publication

  1. The interaction of insoluble Amyloid-β with soluble Amyloid-β dimers decreases Amyloid-β plaque numbers. Else F van Gerresheim, Arne Herring, Lothar Gremer, Andreas Müller-Schiffmann, Kathy Keyvani, Carsten Korth. Neuropathol Appl Neurobiol. 2021 Aug;47(5):603-610. doi: 10.1111/nan.12685. Epub 2021 Jan 7. . PubMed

Andres Vargas-Toscano
Dept. of Neurosurgery
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf

PhD Thesis
Personalized brain tumor therapy approaches on glioblastoma stem cell models.

Supervisors

Publications

  1. A Preclinical Pipeline for Translational Precision Medicine-Experiences from a Transdisciplinary Brain Tumor Stem Cell Project. Andres Vargas-Toscano, Christoph Janiak, Michael Sabel, Ulf Dietrich Kahlert. J Pers Med. 2021 Sep 7;11(9):892. doi: 10.3390/jpm11090892.  PubMed

  2. Rapalink-1 Targets Glioblastoma Stem Cells and Acts Synergistically with Tumor Treating Fields to Reduce Resistance against Temozolomide. Andres Vargas-Toscano, Ann-Christin Nickel, Guanzhang Li, Marcel Alexander Kamp, Sajjad Muhammad, Gabriel Leprivier, Ellen Fritsche, Roger A Barker, Michael Sabel, Hans-Jakob Steiger, Wei Zhang, Daniel Hänggi, Ulf Dietrich Kahlert. Cancers (Basel). 2020 Dec 21;12(12):3859. doi: 10.3390/cancers12123859. PubMed

  3. Robot Technology Identifies a Parkinsonian Therapeutics Repurpose to Target Stem Cells of Glioblastoma. Andres Vargas-Toscano, Dilaware Khan, Ann-Christin Nickel, Michael Hewera, Marcel Alexander Kamp, Igor Fischer, Hans-Jakob Steiger, Wei Zhang, Sajjad Muhammad, Daniel Hänggi, Ulf Dietrich Kahlert. CNS Oncol. 2020 Jun;9(2):CNS58. doi: 10.2217/cns-2020-0004. Epub 2020 May 28. PubMed

  4. Influence of synthesis methods on the internalization of fluorescent gold nanoparticles into glioblastoma stem-like cells. Giesen B, Nickel AC, Garzón Manjón A, Vargas Toscano A, Scheu C, Kahlert UD, Janiak C. J Inorg Biochem. 2020 Feb;203:110952. doi: 10.1016/j.jinorgbio.2019.110952. Epub 2019 Nov 23. PMID: 31794896 PubMed

  5. Seizure frequency reduction after posteromedial hypothalamus deep brain stimulation in drug-resistant epilepsy associated with intractable aggressive behavior. Benedetti-Isaac JC, Torres-Zambrano M, Vargas-Toscano A, Perea-Castro E, Alcalá-Cerra G, Furlanetti LL, Reithmeier T, Tierney TS, Anastasopoulos C, Fonoff ET, Contreras Lopez WO. Epilepsia. 2015 Jul;56(7):1152-61. doi: 10.1111/epi.13025. Epub 2015 Jul 4. PMID: 26146753 PubMed

Responsible for the content: