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PhD Researchers

Seda Akgün
Institute for Molecular Medicine I
Heinrich-Heine-University
40225 Düsseldorf


PhD Thesis
Impact of genotoxins on autophagic processes during neuronal differentiation.

Supervisor

Publications

  1. Modulation of Specific Sphingosine-1-Phosphate Receptors Augments a Repair Mediating Schwann Cell Phenotype. Jessica Schira-Heinen, Luzhou Wang, Seda Akgün, Sofia Blum, Brigida Ziegler, André Heinen, Hans-Peter Hartung, Patrick Küry. Int J Mol Sci. 2022 Sep 7;23(18):10311. doi: 10.3390/ijms231810311. PubMed
  2. Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells. Yadong Sun, Niklas Berleth, Wenxian Wu, David Schlütermann, Jana Deitersen, Fabian Stuhldreier, Lena Berning, Annabelle Friedrich, Seda Akgün, María José Mendiburo, Sebastian Wesselborg, Marcus Conrad, Carsten Berndt, Björn Stork. Cell Death Dis. 2021 Oct 29;12(11):1028. doi: 10.1038/s41419-021-04306-2. PubMed

Zülal Bas
Institute of Neuropathology
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf


PhD Thesis
Unfolding the mechanisms of a cell death type induced under glucose starvation.

Supervisors

Publication

  1. mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism. Tal Levy, Kai Voeltzke, Laura Hruby, Khawla Alasad, Zuelal Bas, Marteinn Snaebjörnsson, Ran Marciano, Katerina Scharov, Mélanie Planque, Kim Vriens, Stefan Christen, Cornelius M Funk, Christina Hassiepen, Alisa Kahler, Beate Heider, Daniel Picard, Jonathan K M Lim, Anja Stefanski, Katja Bendrin, Andres Vargas-Toscano, Ulf D Kahlert, Kai Stühler, Marc Remke, Moshe Elkabets, Thomas G P Grünewald, Andreas S Reichert, Sarah-Maria Fendt, Almut Schulze, Guido Reifenberger, Barak Rotblat, Gabriel Leprivier. Nat Commun. 2024 May 14;15(1):4083. doi: 10.1038/s41467-024-48386-y. PubMed
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Viola Bornemann
Institute of Neurobiology
Heinrich-Heine-University Düsseldorf 40225 Düsseldorf


PhD Thesis
Physiologische Eigenschaften Na+-abhängiger GABA Transporter 

Supervisors

Janine Ciftcioglu
Institute of Neuropathology
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf



PhD Thesis

Molecular mechanisms regulating the differentiation potential of neural stem and progenitor cells upon gamma irradiation.

Supervisors

José Michele Doeren
Comparative Psychology
Department of Experimental Psychology
Heinrich-Heine-University
40225 Düsseldorf

PhD Thesis
Neural mechanisms of affective processing, reward and cognition in the context of social behaviour.

Supervisors

Katharina Everaerts
Institute of Neurobiology
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf


PhD Thesis
Ion homeostasis and acute metabolic inhibition in the murine brain.

Supervisors

Publications

  1. Inward Operation of Sodium-Bicarbonate Cotransporter 1 Promotes Astrocytic Na+ Loading and Loss of ATP in Mouse Neocortex during Brief Chemical Ischemia. Katharina Everaerts, Pawan Thapaliya, Nils Pape, Simone Durry, Sara Eitelmann, Eleni Roussa, Ghanim Ullah, Christine R Rose. Cells. 2023 Nov 21;12(23):2675. doi: 10.3390/cells12232675. PubMed
  2. Ca2+-dependent rapid uncoupling of astrocytes upon brief metabolic stress. Sara Eitelmann, Katharina Everaerts, Laura Petersilie, Christine R Rose, Jonathan Stephan. Front Cell Neurosci. 2023 Oct 11:17:1151608. doi: 10.3389/fncel.2023.1151608. eCollection 2023. PubMed
  3. Novel algorithms for improved detection and analysis of fluorescent signal fluctuations. Gebhard Stopper, Laura C Caudal, Phillip Rieder, Davide Gobbo, Laura Stopper, Lisa Felix, Katharina Everaerts, Xianshu Bai, Christine R Rose, Anja Scheller, Frank Kirchhoff. 2023 Nov;475(11):1283-1300. doi: 10.1007/s00424-023-02855-3. Epub 2023 Sep 13. PubMed ID: 37700120 PubMed
  4. Cell-Type Dependent Regulation of the Electrogenic Na +/HCO 3- Cotransporter 1 (NBCe1) by Hypoxia and Acidosis in Glioblastoma. Marina Giannaki, Debora E Ruf, Emilie Pfeifer, Katharina Everaerts, Dieter H Heiland, Oliver Schnell, Christine R Rose, Eleni Roussa. Int J Mol Sci. 2022 Aug 11;23(16):8975. doi: 10.3390/ijms23168975. PubMed
  5. Changes in Astroglial K + upon Brief Periods of Energy Deprivation in the Mouse Neocortex. Sara Eitelmann, Jonathan Stephan, Katharina Everaerts, Simone Durry, Nils Pape, Niklas J Gerkau, Christine R Rose. Int J Mol Sci. 2022 Apr 27;23(9):4836. doi: 10.3390/ijms23094836. PubMed
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Jianfeng Fan
Institute of Neurobiology
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf


PhD Thesis
Ischemia-induced changes of astrocyte and neuron properties

Supervisors

 

Sonja Heiduschka
Department of General Pediatrics
University Children’s Hospital
Stem Cell Metabolism
Heinrich-Heine-University
40225 Düsseldorf


PhD Thesis
Dissecting the neural pathology of Leigh syndrome using patient-derived brain organoids.

Supervisors

Publication

  1. Cortical brain organoid slices (cBOS) for the study of human neural cells in minimal networks. Laura Petersilie, Sonja Heiduschka, Joel S E Nelson, Louis A Neu, Stephanie Le, Ruchika Anand, Karl W Kafitz, Alessandro Prigione, Christine R Rose. iScience. 2024 Mar 4;27(4):109415. doi: 10.1016/j.isci.2024.109415. eCollection 2024 Apr 19. PubMed

Lena Jentsch
IUF- Leibniz Research Institute for Environmental Medicine
Auf’m Hennekamp 50
40225 Düsseldorf


PhD Thesis
Natural compounds as suppressors of mitochondrial complex I deficiency-associated diseases in mammalian cell models.

Supervisor

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Diana Klees
Klinik für Neurologie
Translationale Neurodegeneration und Neuroprotektion
Moorenstr. 5
40225 Düsseldorf


PhD Thesis
Evaluation of relevant factors involved in neurodegeneration, regeneration and demyelination in preclinical models of inflammatory and degenerative CNS disorders using visual system readouts.

Supervisors

Christian Kroll
Dept. of Neurology - Molecular Neurology
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf


PhD Thesis
Hypoxia and sirtuin 1 in neural stem & progenitor cells.

Supervisors

Dang Tri Le
Cell Biology
Leibniz Research Institute for Environmental Medicine
40225 Düsseldorf

PhD Thesis
Life span-resolved nanotoxicology: amyloid aggregation, neuronal targets and vulnerable age-groups in the nematode Caenorhabditis elegans.

Supervisors

Publications

  1. Peripheral neuropathy, protein aggregation and serotonergic neurotransmission: Distinctive bio-interactions of thiacloprid and thiamethoxam in the nematode Caenorhabditis elegans. Inge Scharpf, Sylwia Cichocka, Dang Tri Le, Anna von Mikecz. Environ Pollut. 2022 Dec 1;314:120253.doi: 10.1016/j.envpol.2022.120253. Epub 2022 Sep 23. PubMed
  2. How to keep up with the analysis of classic and emerging neurotoxins: Age-resolved fitness tests in the animal model Caenorhabditis elegans - a step-by-step protocol. Indra Hering, Dang Tri Le, Anna von Mikecz. EXCLI J. 2022 Jan 31;21:344-353. doi: 10.17179/excli2021-4626. eCollection 2022. PubMed

Stephanie Le
Department of General Pediatrics
University Children’s Hospital
Stem Cell Metabolism
Heinrich-Heine-University
40225 Düsseldorf


PhD Thesis
Brain organoids for modelling Leigh syndrome caused by complex I mutations.

Supervisor

Publication

  1. Balancing neuronal activity to fight neurodevelopmental disorders. Stephanie Le, Carmen Menacho, Alessandro Prigione. Trends Neurosci. 2024 Apr;47(4):241-242. doi: 10.1016/j.tins.2024.03.002. Epub 2024 Mar 22. PubMed
  2. Cortical brain organoid slices (cBOS) for the study of human neural cells in minimal networks. Laura Petersilie, Sonja Heiduschka, Joel S E Nelson, Louis A Neu, Stephanie Le, Ruchika Anand, Karl W Kafitz, Alessandro Prigione, Christine R Rose. iScience. 2024 Mar 4;27(4):109415. doi: 10.1016/j.isci.2024.109415. eCollection 2024 Apr 19. PubMed
  3. Activated microglia and neuroinflammation as a pathogenic mechanism in Leigh syndrome. Nastaran Daneshgar, Mariah R Leidinger, Stephanie Le, Marco Hefti, Alessandro Prigione, Dao-Fu Dai. Front Neurosci. 2023 Jan 18;16:1068498. doi: 10.3389/fnins.2022.1068498. eCollection 2022. PubMed

Oksana Lewandowska
Institute of Neuropathology
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf


PhD Thesis
Establishment of a glioblastoma model in Drosophila melanogaster as a tool for functional genomics screening

Supervisors

Selene Lickfett
Department of General Pediatrics
University Children’s Hospital
Stem Cell Metabolism
Heinrich-Heine-University
40225 Düsseldorf


PhD Thesis
Genetic knock-down screenings in human iPSC-derived neurons.

Supervisor

Publications

  1. High-content analysis of neuronal morphology in human iPSC-derived neurons. Selene Lickfett, Carmen Menacho, Annika Zink, Narasimha Swamy Telugu, Mathias Beller, Sebastian Diecke, Sidney Cambridge, Alessandro Prigione. STAR Protoc. 2022 Aug 6;3(3):101567. doi: 10.1016/j.xpro.2022.101567. eCollection 2022 Sep 16. PubMed

  2. A call for consensus guidelines on monitoring the integrity of nuclear and mitochondrial genomes in human pluripotent stem cells. Andrea Rossi, Selene Lickfett, Soraia Martins, Alessandro Prigione. Stem Cell Reports. 2022 Apr 12;17(4):707-710.doi: 10.1016/j.stemcr.2022.01.019. Epub 2022 Mar 3. PubMed

Carmen Maria Menacho Pando
Department of General Pediatrics
University Children’s Hospital
Stem Cell Metabolism
Heinrich-Heine-University
40225 Düsseldorf


PhD Thesis
Revealing the pathological mechanism of neural impairment of Leigh syndrome using engineered patient-derived neural cells.

Supervisor

Publications

  1. Balancing neuronal activity to fight neurodevelopmental disorders. Stephanie Le, Carmen Menacho, Alessandro Prigione. Trends Neurosci. 2024 Apr;47(4):241-242. doi: 10.1016/j.tins.2024.03.002. Epub 2024 Mar 22. PubMed
  2. High-content analysis of neuronal morphology in human iPSC-derived neurons. Selene Lickfett, Carmen Menacho, Annika Zink, Narasimha Swamy Telugu, Mathias Beller, Sebastian Diecke, Sidney Cambridge, Alessandro Prigione. STAR Protoc. 2022 Aug 6;3(3):101567. doi: 10.1016/j.xpro.2022.101567. eCollection 2022 Sep 16. PubMed
  3. Generation of Human Brain Organoids for Mitochondrial Disease Modeling. Le S, Petersilie L, Inak G, Menacho-Pando C, Kafitz KW, Rybak-Wolf A, Rajewsky N, Rose CR, Prigione A. J Vis Exp. 2021 Jun 21;(172). doi: 10.3791/62756. PubMed

Louis Anton Neu
Institute of Neurobiology
Heinrich-Heine-Universität
Universitätstr. 1
40225 Düsseldorf

PhD Thesis
Expression of genetically encoded biosensors for the functional characterization of murine and human brain tissue

Supervisors

Co-Supervisor

Publication

  1. Cortical brain organoid slices (cBOS) for the study of human neural cells in minimal networks. Laura Petersilie, Sonja Heiduschka, Joel S E Nelson, Louis A Neu, Stephanie Le, Ruchika Anand, Karl W Kafitz, Alessandro Prigione, Christine R Rose. iScience. 2024 Mar 4;27(4):109415. doi: 10.1016/j.isci.2024.109415. eCollection 2024 Apr 19. PubMed

 

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Laura Petersilie
Institute of Neurobiology
Heinrich-Heine-University Düsseldorf 40225 Düsseldorf


PhD Thesis
Influence of metabolic inhibition on the ion homeostasis of brain cells.

Supervisors

Publications

  1. Cortical brain organoid slices (cBOS) for the study of human neural cells in minimal networks. Laura Petersilie, Sonja Heiduschka, Joel S E Nelson, Louis A Neu, Stephanie Le, Ruchika Anand, Karl W Kafitz, Alessandro Prigione, Christine R Rose. iScience. 2024 Mar 4;27(4):109415. doi: 10.1016/j.isci.2024.109415. eCollection 2024 Apr 19. PubMed

  2. Ca2+-dependent rapid uncoupling of astrocytes upon brief metabolic stress. Sara Eitelmann, Katharina Everaerts, Laura Petersilie, Christine R Rose, Jonathan Stephan. Front Cell Neurosci. 2023 Oct 11:17:1151608. doi: 10.3389/fncel.2023.1151608. eCollection 2023. PubMed

  3. Glial Chloride Homeostasis Under Transient Ischemic Stress. Miriam Engels, Manu Kalia, Sarah Rahmati, Laura Petersilie, Peter Kovermann, Michel J A M van Putten, Christine R Rose, Hil G E Meijer, Thomas Gensch, Christoph Fahlke. Front Cell Neurosci. 2021 Sep 16;15:735300. doi: 10.3389/fncel.2021.735300. eCollection 2021. PubMed

  4. Human Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Produce Distinct Neural 3D In Vitro Models Depending on Alginate/Gellan Gum/Laminin Hydrogel Blend Properties. Kapr J, Petersilie L, Distler T, Lauria I, Bendt F, Sauter CM, Boccaccini AR, Rose CR, Fritsche E. Adv Healthc Mater. 2021 Aug;10(16):e2100131. doi: 10.1002/adhm.202100131. Epub 2021 Jul 1. PubMed

  5. Generation of Human Brain Organoids for Mitochondrial Disease Modeling. Le S, Petersilie L, Inak G, Menacho-Pando C, Kafitz KW, Rybak-Wolf A, Rajewsky N, Rose CR, Prigione A. J Vis Exp. 2021 Jun 21;(172). doi: 10.3791/62756. PubMed

  6. Altered Gap Junction Network Topography in Mouse Models for Human Hereditary Deafness. Sara Eitelmann, Laura Petersilie, Christine R Rose, Jonathan Stephan. Int J Mol Sci. 2020 Oct 6;21(19):7376. doi: 10.3390/ijms21197376. PubMed

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Laura Reiche
Dept. of Neurology - Neuroregeneration
Heinrich-Heine-University Düsseldorf 40225 Düsseldorf


PhD Thesis
C21orf91 as a novel modulator of glial cell determination and differentiation.

Supervisors

Publications

  1. Molecular dissection of HERV-W dependent microglial- and astroglial cell polarization. Joel Gruchot, Laura Reiche, Luisa Werner, Felisa Herrero, Jessica Schira-Heinen, Urs Meyer, Patrick Küry. Microbes Infect. 2024 Jun 27:105382. doi: 10.1016/j.micinf.2024.105382. Online ahead of print. PubMed

  2. Human endogenous retrovirus type-W and multiple sclerosis-related smoldering neuroinflammation. Joel Gruchot, Laura Reiche, Andrew Chan, Robert Hoepner, Patrick Küry. Neural Regen Res. 2025 Mar 1;20(3):813-814. doi: 10.4103/NRR.NRR-D-24-00121. Epub 2024 May 13. PubMed

  3. Star power: harnessing the reactive astrocyte response to promote remyelination in multiple sclerosis. Markley Silva Oliveira Junior, Laura Reiche, Emerson Daniele, Ines Kortebi, Maryam Faiz, Patrick Küry. Neural Regen Res. 2024 Mar;19(3):578-582. doi: 10.4103/1673-5374.380879. PubMed

  4. Transgenic expression of the HERV-W envelope protein leads to polarized glial cell populations and a neurodegenerative environment. Joel Gruchot, Isabel Lewen, Michael Dietrich, Laura Reiche, Mustafa Sindi, Christina Hecker, Felisa Herrero, Benjamin Charvet, Ulrike Weber-Stadlbauer, Hans-Peter Hartung, Philipp Albrecht, Hervé Perron, Urs Meyer, Patrick Küry. Proc Natl Acad Sci U S A. 2023 Sep 19;120(38):e2308187120. doi: 10.1073/pnas.2308187120. Epub 2023 Sep 11. PubMed

  5. A Novel Ex Vivo Model to Study Therapeutic Treatments for Myelin Repair following Ischemic Damage. Luisa Werner, Michael Gliem, Nicole Rychlik, Goran Pavic, Laura Reiche, Frank Kirchhoff, Markley Silva Oliveira Junior, Joel Gruchot, Sven G Meuth, Patrick Küry, Peter Göttle. Int J Mol Sci. 2023 Jun 30;24(13):10972. doi: 10.3390/ijms241310972. PubMed

  6. Teriflunomide as a therapeutic means for myelin repair. Peter Göttle, Janos Groh, Laura Reiche, Joel Gruchot, Nicole Rychlik, Luisa Werner, Iria Samper Agrelo, Rainer Akkermann, Annika Zink, Alessandro Prigione, Hans-Peter Hartung, Rudolf Martini, Patrick Küry. J Neuroinflammation. 2023 Jan 7;20(1):7. doi: 10.1186/s12974-022-02686-6. PubMed

  7. Siponimod Modulates the Reaction of Microglial Cells to Pro-Inflammatory Stimulation. Joel Gruchot, Ferdinand Lein, Isabel Lewen, Laura Reiche, Vivien Weyers, Patrick Petzsch, Peter Göttle, Karl Köhrer, Hans-Peter Hartung, Patrick Küry, David Kremer. Int J Mol Sci. 2022 Oct 31;23(21):13278. doi: 10.3390/ijms232113278. PubMed

  8. Myelin repair is fostered by the corticosteroid medrysone specifically acting on astroglial subpopulations. Markley Silva Oliveira Junior, Jessica Schira-Heinen, Laura Reiche, Seulki Han, Vanessa Cristina Meira de Amorim, Isabel Lewen, Joel Gruchot, Peter Göttle, Rainer Akkermann, Kasum Azim, Patrick Küry. EBioMedicine. 2022 Aug 8;83:104204. doi: 10.1016/j.ebiom.2022.104204. Online ahead of print. PubMed

  9. TLR4 Associated Signaling Disrupters as a New Means to Overcome HERV-W Envelope-Mediated Myelination Deficits. Peter Göttle, Kira Schichel, Laura Reiche, Luisa Werner, Annika Zink, Alessandro Prigione, Patrick Küry. Front Cell Neurosci. 2021 Nov 23;15:777542. doi: 10.3389/fncel.2021.777542. eCollection 2021. PubMed

  10. C21orf91 Regulates Oligodendroglial Precursor Cell Fate-A Switch in the Glial Lineage? Laura Reiche, Peter Göttle, Lydie Lane, Paula Duek, Mina Park, Kasum Azim, Jana Schütte, Anastasia Manousi, Jessica Schira-Heinen, Patrick Küry. Front Cell Neurosci. 2021 Mar;65:103276. doi: 10.1016/j.ebiom.2021.103276. Epub 2021 Mar 10. PubMed

  11. Identification of novel myelin repair drugs by modulation of oligodendroglial differentiation competence. Anastasia Manousi, Peter Göttle, Laura Reiche, Qiao-Ling Cui, Luke M Healy, Rainer Akkermann, Joel Gruchot, Jessica Schira-Heinen, Jack P Antel, Hans-Peter Hartung, Patrick Küry. EBioMedicine. 2021 Mar;65:103276. doi: 10.1016/j.ebiom.2021.103276. Epub 2021 Mar 10. PubMed

  12. Heterogeneous fate choice of genetically modulated adult neural stem cells in gray and white matter of the central nervous system. Beyer F, Jadasz J, Samper Agrelo I, Schira-Heinen J, Groh J, Manousi A, Bütermann C, Estrada V, Reiche L, Cantone M, Vera J, Viganò F, Dimou L, Müller HW, Hartung HP, Küry P. Glia. 2020 Feb;68(2):393-406. doi: 10.1002/glia.23724. Epub 2019 Oct 21. PubMed

  13. Aberrant Oligodendrogenesis in Down Syndrome: Shift in Gliogenesis? Reiche L, Küry P, Göttle P. Cells. 2019 Dec 7;8(12). pii: E1591. doi: 10.3390/cells8121591. PubMed

  14. Teriflunomide promotes oligodendroglial differentiation and myelination. Göttle P, Manousi A, Kremer D, Reiche L, Hartung HP, Küry P. J Neuroinflammation. 2018 Mar 13;15(1):76. doi: 10.1186/s12974-018-1110-z. PubMed

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Mustafa Sindi
Dept. of Neurology
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf


PhD Thesis
Investigation and evaluation of neuroprotective and regenerative strategies in experimental models of Multiple Sclerosis.

Supervisors

  • Prof. Dr. Philipp Albrecht
  • Prof. Dr. Bodo Levkau

Publications

  1. Gruchot J, Lewen I, Dietrich M, Reiche L, Sindi M, Hecker C, Herrero F, Charvet B, Weber-Stadlbauer U, Hartung HP, Albrecht P, Perron H, Meyer U, Küry P. Transgenic expression of the HERV-W envelope protein leads to polarized glial cell populations and a neurodegenerative environment. Proc Natl Acad Sci U S A. 2023 Sep 19;120(38):e2308187120. doi: 10.1073/pnas.2308187120. Epub 2023 Sep 11. PMID: 37695891.

  2. Sindi M, Hecker C, Issberner A, Ruck T, Meuth SG, Albrecht P, Dietrich M. S1PR-1/5 modulator RP-101074 shows beneficial effects in a model of central nervous system degeneration. Front Immunol. 2023 Aug 9;14:1234984. doi: 10.3389/fimmu.2023.1234984. PMID: 37638037; PMCID: PMC10450045.

  3. Frenger MJ, Hecker C, Sindi M, Issberner A, Hartung HP, Meuth SG, Dietrich M, Albrecht P. Semi-Automated Live Tracking of Microglial Activation in CX3CR1GFP Mice During Experimental Autoimmune Encephalomyelitis by Confocal Scanning Laser Ophthalmoscopy. Front Immunol. 2021 Oct 21;12:761776. doi: 10.3389/fimmu.2021.761776. PMID: 34745138; PMCID: PMC8567040.

  4.  Zhang P, Li T, Liu C, Sindi M, Cheng X, Qi S, Liu X, Yan Y, Bao Y, Brand-Saberi B, Yang W, Wang G, Yang X. Nano-sulforaphane attenuates PhIP-induced early abnormal embryonic neuro-development. Ann Anat. 2021 Jan;233:151617. doi: 10.1016/j.aanat.2020.151617. Epub 2020 Oct 21. PMID: 33098981.

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Frauke Stölting
Institute of Neuropathology
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf


PhD Thesis
Investigating oncogene signaling-mediated glycoproteome remodeling

Supervisors

Publications

  • Oncogenic RAS signaling suppresses ferroptosis via transcriptional upregulation of GCH1, Jonathan K. M. Lim, Frauke Stölting, Tal Levy, Leonie Thewes, Daniel Picard, Sofya Tishina, Hai-Feng Zhang, Oksana Lewandowska, Tobias Reiff, Marc Remke, Johannes Brägelmann, Filippo Beleggia, Carsten Berndt, Silvia von Karstedt, Guido Reifenberger, Barak Rotblat, Gabriel Leprivier, bioRxiv, January 29, 2024, doi: doi.org/10.1101/2024.01.27.577524, this article is a preprint and has not been certified by peer review.
  • Early life adversity drives sex-specific anhedonia and meningeal immune gene expression through mast cell activation, Natalia Duque-Wilckens, Robert Teis, Erika Sarno, Frauke Stoelting, Sonia Khalid, Zakaria Dairi, Alex Douma, Nidia Maradiaga, Stina Hench, Christine D Dharshika, Kyan M Thelen, Brian Gulbransen, A J Robison, Adam J Moeser, Brain Behav Immun. 2022 Jul;103:73-84. doi: 10.1016/j.bbi.2022.03.009. Epub 2022 Mar 24. PMID: 35339629; PMCID: PMC9149134.
  • WBP2-Onkogen-Regulation durch miRNA-prozessierenden Dicer im Hippo/MST-Signalweg, Frauke Stoelting, Journal Club, March 2021, BIOspektrum 27(2):172-175, DOI:10.1007/s12268-021-1552-1
  • The histamine H3R and dopamine D2R/D3R antagonist ST-713 ameliorates autism-like behavioral features in BTBR T+tf/J mice by multiple actions, Karthikkumar Venkatachalam, Nermin Eissa, Mohamed Al Awad, Petrilla Jayaprakash, Sicheng Zhong, Frauke Stölting, Holger Stark, Bassem Sadek, Biomedicine & Pharmacotherapy, Volume 138, 2021, 111517, ISSN 0753-3322, DOI: doi.org/10.1016/j.biopha.2021.111517.

Leonie Christin Thewes
Dept. of Neurology - Thiology
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf


PhD Thesis
Ferroptosis in development and diseases.

Supervisors

Publications:

  1. Ferroptosis in health and disease. Carsten Berndt, Hamed Alborzinia, Vera Skafar Amen, Scott Ayton, Uladzimir Barayeu, Alexander Bartelt, Hülya Bayir, Christina M Bebber, Kivanc Birsoy, Jan P Böttcher, Simone Brabletz, Thomas Brabletz, Ashley R Brown, Bernhard Brüne, Giorgia Bulli, Alix Bruneau, Quan Chen, Gina M DeNicola, Tobias P Dick, Ayelén Distéfano, Scott J Dixon, Jan B Engler, Julia Esser-von Bieren, Maria Fedorova, José Pedro Friedmann Angeli, Manuel A Friese, Dominic C Fuhrmann, Ana J García-Sáez, Karolina Garbowicz, Magdalena Götz, Wei Gu, Linda Hammerich, Behrouz Hassannia, Xuejun Jiang, Aicha Jeridi, Yun Pyo Kang, Valerian E Kagan, David B Konrad, Stefan Kotschi, Peng Lei, Marlène Le Tertre, Sima Lev, Deguang Liang, Andreas Linkermann, Carolin Lohr, Svenja Lorenz, Tom Luedde, Axel Methner, Bernhard Michalke, Anna V Milton, Junxia Min, Eikan Mishima, Sebastian Müller, Hozumi Motohashi, Martina U Muckenthaler, Shohei Murakami, James A Olzmann, Gabriela Pagnussat, Zijan Pan, Thales Papagiannakopoulos, Lohans Pedrera Puentes, Derek A Pratt, Bettina Proneth, Lukas Ramsauer, Raphael Rodriguez, Yoshiro Saito, Felix Schmidt, Carina Schmitt, Almut Schulze, Annemarie Schwab, Anna Schwantes, Mariluz Soula, Benedikt Spitzlberger, Brent R Stockwell, Leonie Thewes, Oliver Thorn-Seshold, Shinya Toyokuni, Wulf Tonnus, Andreas Trumpp, Peter Vandenabeele, Tom Vanden Berghe, Vivek Venkataramani, Felix C E Vogel, Silvia von Karstedt, Fudi Wang, Frank Westermann, Chantal Wientjens, Christoph Wilhelm, Michele Wölk, Katherine Wu, Xin Yang, Fan Yu, Yilong Zou, Marcus Conrad. Redox Biol. 2024 May 30:75:103211. doi: 10.1016/j.redox.2024.103211. Online ahead of print. PubMed
  2. JNK Signalling Regulates Self-Renewal of Proliferative Urine-Derived Renal Progenitor Cells via Inhibition of Ferroptosis. Lisa Nguyen, Leonie Thewes, Michelle Westerhoff, Wasco Wruck, Andreas S Reichert, Carsten Berndt, James Adjaye. Cells. 2023 Sep 2;12(17):2197. doi: 10.3390/cells12172197. PubMed

Luisa Werner
Dept. of Neurology - Neuroregeneration
Heinrich-Heine-University Düsseldorf 40225 Düsseldorf


PhD Thesis
Pharmacological promotion of CNS regeneration following neurodegenerative diseases via specific SP1R modulation.

Supervisors

Publications:

  1. Molecular dissection of HERV-W dependent microglial- and astroglial cell polarization. Joel Gruchot, Laura Reiche, Luisa Werner, Felisa Herrero, Jessica Schira-Heinen, Urs Meyer, Patrick Küry. Microbes Infect. 2024 Jun 27:105382. doi: 10.1016/j.micinf.2024.105382. Online ahead of print. PubMed
  2. A Novel Ex Vivo Model to Study Therapeutic Treatments for Myelin Repair following Ischemic Damage. Luisa Werner, Michael Gliem, Nicole Rychlik, Goran Pavic, Laura Reiche, Frank Kirchhoff, Markley Silva Oliveira Junior, Joel Gruchot, Sven G Meuth, Patrick Küry, Peter Göttle. Int J Mol Sci. 2023 Jun 30;24(13):10972. doi: 10.3390/ijms241310972. PubMed
  3. Teriflunomide as a therapeutic means for myelin repair. Peter Göttle, Janos Groh, Laura Reiche, Joel Gruchot, Nicole Rychlik, Luisa Werner, Iria Samper Agrelo, Rainer Akkermann, Annika Zink, Alessandro Prigione, Hans-Peter Hartung, Rudolf Martini, Patrick Küry. J Neuroinflammation. 2023 Jan 7;20(1):7. doi: 10.1186/s12974-022-02686-6. PubMed
  4. TLR4 Associated Signaling Disrupters as a New Means to Overcome HERV-W Envelope-Mediated Myelination Deficits. Peter Göttle, Kira Schichel, Laura Reiche, Luisa Werner, Annika Zink, Alessandro Prigione, Patrick Küry. Front Cell Neurosci. 2021 Nov 23:15:777542. doi: 10.3389/fncel.2021.777542. eCollection 2021. PubMed
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