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PhD Researchers

Seda Akgün
Institute for Molecular Medicine I
Heinrich-Heine-University
40225 Düsseldorf


PhD Thesis
Impact of genotoxins on autophagic processes during neuronal differentiation.

Supervisor

Publications

  1. Modulation of Specific Sphingosine-1-Phosphate Receptors Augments a Repair Mediating Schwann Cell Phenotype. Jessica Schira-Heinen, Luzhou Wang, Seda Akgün, Sofia Blum, Brigida Ziegler, André Heinen, Hans-Peter Hartung, Patrick Küry. Int J Mol Sci. 2022 Sep 7;23(18):10311. doi: 10.3390/ijms231810311. PubMed
  2. Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells. Yadong Sun, Niklas Berleth, Wenxian Wu, David Schlütermann, Jana Deitersen, Fabian Stuhldreier, Lena Berning, Annabelle Friedrich, Seda Akgün, María José Mendiburo, Sebastian Wesselborg, Marcus Conrad, Carsten Berndt, Björn Stork. Cell Death Dis. 2021 Oct 29;12(11):1028. doi: 10.1038/s41419-021-04306-2. PubMed

Zülal Bas
Institute of Neuropathology
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf


PhD Thesis
Unfolding the mechanisms of a cell death type induced under glucose starvation.

Supervisors

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Viola Bornemann
Institute of Neurobiology
Heinrich-Heine-University Düsseldorf 40225 Düsseldorf


PhD Thesis
Physiologische Eigenschaften Na+-abhängiger GABA Transporter 

Supervisors

Janine Ciftcioglu
Institute of Neuropathology
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf



PhD Thesis

Molecular mechanisms regulating the differentiation potential of neural stem and progenitor cells upon gamma irradiation.

Supervisors

José Michele Doeren
Comparative Psychology
Department of Experimental Psychology
Heinrich-Heine-University
40225 Düsseldorf

PhD Thesis
Neural mechanisms of affective processing, reward and cognition in the context of social behaviour.

Supervisors

Katharina Everaerts
Institute of Neurobiology
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf


PhD Thesis
Ion homeostasis and acute metabolic inhibition in the murine brain.

Supervisors

Publications

  1. Inward Operation of Sodium-Bicarbonate Cotransporter 1 Promotes Astrocytic Na+ Loading and Loss of ATP in Mouse Neocortex during Brief Chemical Ischemia. Katharina Everaerts, Pawan Thapaliya, Nils Pape, Simone Durry, Sara Eitelmann, Eleni Roussa, Ghanim Ullah, Christine R Rose. Cells. 2023 Nov 21;12(23):2675. doi: 10.3390/cells12232675. PubMed
  2. Ca2+-dependent rapid uncoupling of astrocytes upon brief metabolic stress. Sara Eitelmann, Katharina Everaerts, Laura Petersilie, Christine R Rose, Jonathan Stephan. Front Cell Neurosci. 2023 Oct 11:17:1151608. doi: 10.3389/fncel.2023.1151608. eCollection 2023. PubMed
  3. Novel algorithms for improved detection and analysis of fluorescent signal fluctuations. Gebhard Stopper, Laura C Caudal, Phillip Rieder, Davide Gobbo, Laura Stopper, Lisa Felix, Katharina Everaerts, Xianshu Bai, Christine R Rose, Anja Scheller, Frank Kirchhoff. 2023 Nov;475(11):1283-1300. doi: 10.1007/s00424-023-02855-3. Epub 2023 Sep 13. PubMed ID: 37700120 PubMed
  4. Cell-Type Dependent Regulation of the Electrogenic Na +/HCO 3- Cotransporter 1 (NBCe1) by Hypoxia and Acidosis in Glioblastoma. Marina Giannaki, Debora E Ruf, Emilie Pfeifer, Katharina Everaerts, Dieter H Heiland, Oliver Schnell, Christine R Rose, Eleni Roussa. Int J Mol Sci. 2022 Aug 11;23(16):8975. doi: 10.3390/ijms23168975. PubMed
  5. Changes in Astroglial K + upon Brief Periods of Energy Deprivation in the Mouse Neocortex. Sara Eitelmann, Jonathan Stephan, Katharina Everaerts, Simone Durry, Nils Pape, Niklas J Gerkau, Christine R Rose. Int J Mol Sci. 2022 Apr 27;23(9):4836. doi: 10.3390/ijms23094836. PubMed
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Jianfeng Fan
Dept. of Neurology - Neuroregeneration
Institute of Neurobiology
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf


PhD Thesis
Ischemia-induced changes of astrocyte and neuron properties

Supervisors

 

Sonja Heiduschka
Department of General Pediatrics
University Children’s Hospital
Stem Cell Metabolism
Heinrich-Heine-University
40225 Düsseldorf


PhD Thesis
Dissecting the neural pathology of Leigh syndrome using patient-derived brain organoids.

Supervisors

Lena Jentsch
IUF- Leibniz Research Institute for Environmental Medicine
Auf’m Hennekamp 50
40225 Düsseldorf


PhD Thesis
Natural compounds as suppressors of mitochondrial complex I deficiency-associated diseases in mammalian cell models.

Supervisor

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Diana Klees
Klinik für Neurologie
Translationale Neurodegeneration und Neuroprotektion
Moorenstr. 5
40225 Düsseldorf


PhD Thesis
Evaluation of relevant factors involved in neurodegeneration, regeneration and demyelination in preclinical models of inflammatory and degenerative CNS disorders using visual system readouts.

Supervisors

Christian Kroll
Dept. of Neurology - Molecular Neurology
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf


PhD Thesis
Hypoxia and sirtuin 1 in neural stem & progenitor cells.

Supervisors

Dang Tri Le
Cell Biology
Leibniz Research Institute for Environmental Medicine
40225 Düsseldorf

PhD Thesis
Life span-resolved nanotoxicology: amyloid aggregation, neuronal targets and vulnerable age-groups in the nematode Caenorhabditis elegans.

Supervisors

Stephanie Le
Department of General Pediatrics
University Children’s Hospital
Stem Cell Metabolism
Heinrich-Heine-University
40225 Düsseldorf


PhD Thesis
Brain organoids for modelling Leigh syndrome caused by complex I mutations.

Supervisor

Publication

  1. Activated microglia and neuroinflammation as a pathogenic mechanism in Leigh syndrome. Nastaran Daneshgar, Mariah R Leidinger, Stephanie Le, Marco Hefti, Alessandro Prigione, Dao-Fu Dai. Front Neurosci. 2023 Jan 18;16:1068498. doi: 10.3389/fnins.2022.1068498. eCollection 2022. PubMed

Oksana Lewandowska
Institute of Neuropathology
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf


PhD Thesis
Establishment of a glioblastoma model in Drosophila melanogaster as a tool for functional genomics screening

Supervisors

Selene Lickfett
Department of General Pediatrics
University Children’s Hospital
Stem Cell Metabolism
Heinrich-Heine-University
40225 Düsseldorf


PhD Thesis
Genetic knock-down screenings in human iPSC-derived neurons.

Supervisor

Publications

  1. High-content analysis of neuronal morphology in human iPSC-derived neurons. Selene Lickfett, Carmen Menacho, Annika Zink, Narasimha Swamy Telugu, Mathias Beller, Sebastian Diecke, Sidney Cambridge, Alessandro Prigione. STAR Protoc. 2022 Aug 6;3(3):101567. doi: 10.1016/j.xpro.2022.101567. eCollection 2022 Sep 16. PubMed

  2. A call for consensus guidelines on monitoring the integrity of nuclear and mitochondrial genomes in human pluripotent stem cells. Andrea Rossi, Selene Lickfett, Soraia Martins, Alessandro Prigione. Stem Cell Reports. 2022 Apr 12;17(4):707-710.doi: 10.1016/j.stemcr.2022.01.019. Epub 2022 Mar 3. PubMed

Carmen Maria Menacho Pando
Department of General Pediatrics
University Children’s Hospital
Stem Cell Metabolism
Heinrich-Heine-University
40225 Düsseldorf


PhD Thesis
Revealing the pathological mechanism of neural impairment of Leigh syndrome using engineered patient-derived neural cells.

Supervisor

Publications

  1. High-content analysis of neuronal morphology in human iPSC-derived neurons. Selene Lickfett, Carmen Menacho, Annika Zink, Narasimha Swamy Telugu, Mathias Beller, Sebastian Diecke, Sidney Cambridge, Alessandro Prigione. STAR Protoc. 2022 Aug 6;3(3):101567. doi: 10.1016/j.xpro.2022.101567. eCollection 2022 Sep 16. PubMed
  2. Generation of Human Brain Organoids for Mitochondrial Disease Modeling. Le S, Petersilie L, Inak G, Menacho-Pando C, Kafitz KW, Rybak-Wolf A, Rajewsky N, Rose CR, Prigione A. J Vis Exp. 2021 Jun 21;(172). doi: 10.3791/62756. PubMed
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Laura Petersilie
Institute of Neurobiology
Heinrich-Heine-University Düsseldorf 40225 Düsseldorf


PhD Thesis
Influence of metabolic inhibition on the ion homeostasis of brain cells.

Supervisors

Publications

  1. Ca2+-dependent rapid uncoupling of astrocytes upon brief metabolic stress. Sara Eitelmann, Katharina Everaerts, Laura Petersilie, Christine R Rose, Jonathan Stephan. Front Cell Neurosci. 2023 Oct 11:17:1151608. doi: 10.3389/fncel.2023.1151608. eCollection 2023. PubMed

  2. Glial Chloride Homeostasis Under Transient Ischemic Stress. Miriam Engels, Manu Kalia, Sarah Rahmati, Laura Petersilie, Peter Kovermann, Michel J A M van Putten, Christine R Rose, Hil G E Meijer, Thomas Gensch, Christoph Fahlke. Front Cell Neurosci. 2021 Sep 16;15:735300. doi: 10.3389/fncel.2021.735300. eCollection 2021. PubMed

  3. Human Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Produce Distinct Neural 3D In Vitro Models Depending on Alginate/Gellan Gum/Laminin Hydrogel Blend Properties. Kapr J, Petersilie L, Distler T, Lauria I, Bendt F, Sauter CM, Boccaccini AR, Rose CR, Fritsche E. Adv Healthc Mater. 2021 Aug;10(16):e2100131. doi: 10.1002/adhm.202100131. Epub 2021 Jul 1. PubMed

  4. Generation of Human Brain Organoids for Mitochondrial Disease Modeling. Le S, Petersilie L, Inak G, Menacho-Pando C, Kafitz KW, Rybak-Wolf A, Rajewsky N, Rose CR, Prigione A. J Vis Exp. 2021 Jun 21;(172). doi: 10.3791/62756. PubMed

  5. Altered Gap Junction Network Topography in Mouse Models for Human Hereditary Deafness. Sara Eitelmann, Laura Petersilie, Christine R Rose, Jonathan Stephan. Int J Mol Sci. 2020 Oct 6;21(19):7376. doi: 10.3390/ijms21197376. PubMed

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Laura Reiche
Dept. of Neurology - Neuroregeneration
Heinrich-Heine-University Düsseldorf 40225 Düsseldorf


PhD Thesis
C21orf91 as a novel modulator of glial cell determination and differentiation.

Supervisors

Publications

  1. Star power: harnessing the reactive astrocyte response to promote remyelination in multiple sclerosis. Markley Silva Oliveira Junior, Laura Reiche, Emerson Daniele, Ines Kortebi, Maryam Faiz, Patrick Küry. Neural Regen Res. 2024 Mar;19(3):578-582. doi: 10.4103/1673-5374.380879. PubMed

  2. Transgenic expression of the HERV-W envelope protein leads to polarized glial cell populations and a neurodegenerative environment. Joel Gruchot, Isabel Lewen, Michael Dietrich, Laura Reiche, Mustafa Sindi, Christina Hecker, Felisa Herrero, Benjamin Charvet, Ulrike Weber-Stadlbauer, Hans-Peter Hartung, Philipp Albrecht, Hervé Perron, Urs Meyer, Patrick Küry. Proc Natl Acad Sci U S A. 2023 Sep 19;120(38):e2308187120. doi: 10.1073/pnas.2308187120. Epub 2023 Sep 11. PubMed

  3. A Novel Ex Vivo Model to Study Therapeutic Treatments for Myelin Repair following Ischemic Damage. Luisa Werner, Michael Gliem, Nicole Rychlik, Goran Pavic, Laura Reiche, Frank Kirchhoff, Markley Silva Oliveira Junior, Joel Gruchot, Sven G Meuth, Patrick Küry, Peter Göttle. Int J Mol Sci. 2023 Jun 30;24(13):10972. doi: 10.3390/ijms241310972. PubMed

  4. Teriflunomide as a therapeutic means for myelin repair. Peter Göttle, Janos Groh, Laura Reiche, Joel Gruchot, Nicole Rychlik, Luisa Werner, Iria Samper Agrelo, Rainer Akkermann, Annika Zink, Alessandro Prigione, Hans-Peter Hartung, Rudolf Martini, Patrick Küry. J Neuroinflammation. 2023 Jan 7;20(1):7. doi: 10.1186/s12974-022-02686-6. PubMed

  5. Siponimod Modulates the Reaction of Microglial Cells to Pro-Inflammatory Stimulation. Joel Gruchot, Ferdinand Lein, Isabel Lewen, Laura Reiche, Vivien Weyers, Patrick Petzsch, Peter Göttle, Karl Köhrer, Hans-Peter Hartung, Patrick Küry, David Kremer. Int J Mol Sci. 2022 Oct 31;23(21):13278. doi: 10.3390/ijms232113278. PubMed

  6. Myelin repair is fostered by the corticosteroid medrysone specifically acting on astroglial subpopulations. Markley Silva Oliveira Junior, Jessica Schira-Heinen, Laura Reiche, Seulki Han, Vanessa Cristina Meira de Amorim, Isabel Lewen, Joel Gruchot, Peter Göttle, Rainer Akkermann, Kasum Azim, Patrick Küry. EBioMedicine. 2022 Aug 8;83:104204. doi: 10.1016/j.ebiom.2022.104204. Online ahead of print. PubMed

  7. TLR4 Associated Signaling Disrupters as a New Means to Overcome HERV-W Envelope-Mediated Myelination Deficits. Peter Göttle, Kira Schichel, Laura Reiche, Luisa Werner, Annika Zink, Alessandro Prigione, Patrick Küry. Front Cell Neurosci. 2021 Nov 23;15:777542. doi: 10.3389/fncel.2021.777542. eCollection 2021. PubMed

  8. C21orf91 Regulates Oligodendroglial Precursor Cell Fate-A Switch in the Glial Lineage? Laura Reiche, Peter Göttle, Lydie Lane, Paula Duek, Mina Park, Kasum Azim, Jana Schütte, Anastasia Manousi, Jessica Schira-Heinen, Patrick Küry. Front Cell Neurosci. 2021 Mar;65:103276. doi: 10.1016/j.ebiom.2021.103276. Epub 2021 Mar 10. PubMed

  9. Identification of novel myelin repair drugs by modulation of oligodendroglial differentiation competence. Anastasia Manousi, Peter Göttle, Laura Reiche, Qiao-Ling Cui, Luke M Healy, Rainer Akkermann, Joel Gruchot, Jessica Schira-Heinen, Jack P Antel, Hans-Peter Hartung, Patrick Küry. EBioMedicine. 2021 Mar;65:103276. doi: 10.1016/j.ebiom.2021.103276. Epub 2021 Mar 10. PubMed

  10. Heterogeneous fate choice of genetically modulated adult neural stem cells in gray and white matter of the central nervous system. Beyer F, Jadasz J, Samper Agrelo I, Schira-Heinen J, Groh J, Manousi A, Bütermann C, Estrada V, Reiche L, Cantone M, Vera J, Viganò F, Dimou L, Müller HW, Hartung HP, Küry P. Glia. 2020 Feb;68(2):393-406. doi: 10.1002/glia.23724. Epub 2019 Oct 21. PubMed

  11. Aberrant Oligodendrogenesis in Down Syndrome: Shift in Gliogenesis? Reiche L, Küry P, Göttle P. Cells. 2019 Dec 7;8(12). pii: E1591. doi: 10.3390/cells8121591. PubMed

  12. Teriflunomide promotes oligodendroglial differentiation and myelination. Göttle P, Manousi A, Kremer D, Reiche L, Hartung HP, Küry P. J Neuroinflammation. 2018 Mar 13;15(1):76. doi: 10.1186/s12974-018-1110-z. PubMed

Foto von

Mustafa Sindi
Dept. of Neurology
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf


PhD Thesis
Investigation and evaluation of neuroprotective and regenerative strategies in experimental models of Multiple Sclerosis.

Supervisors

  • Prof. Dr. Philipp Albrecht
  • Prof. Dr. Bodo Levkau

Publications

  1. Gruchot J, Lewen I, Dietrich M, Reiche L, Sindi M, Hecker C, Herrero F, Charvet B, Weber-Stadlbauer U, Hartung HP, Albrecht P, Perron H, Meyer U, Küry P. Transgenic expression of the HERV-W envelope protein leads to polarized glial cell populations and a neurodegenerative environment. Proc Natl Acad Sci U S A. 2023 Sep 19;120(38):e2308187120. doi: 10.1073/pnas.2308187120. Epub 2023 Sep 11. PMID: 37695891.

  2. Sindi M, Hecker C, Issberner A, Ruck T, Meuth SG, Albrecht P, Dietrich M. S1PR-1/5 modulator RP-101074 shows beneficial effects in a model of central nervous system degeneration. Front Immunol. 2023 Aug 9;14:1234984. doi: 10.3389/fimmu.2023.1234984. PMID: 37638037; PMCID: PMC10450045.

  3. Frenger MJ, Hecker C, Sindi M, Issberner A, Hartung HP, Meuth SG, Dietrich M, Albrecht P. Semi-Automated Live Tracking of Microglial Activation in CX3CR1GFP Mice During Experimental Autoimmune Encephalomyelitis by Confocal Scanning Laser Ophthalmoscopy. Front Immunol. 2021 Oct 21;12:761776. doi: 10.3389/fimmu.2021.761776. PMID: 34745138; PMCID: PMC8567040.

  4.  Zhang P, Li T, Liu C, Sindi M, Cheng X, Qi S, Liu X, Yan Y, Bao Y, Brand-Saberi B, Yang W, Wang G, Yang X. Nano-sulforaphane attenuates PhIP-induced early abnormal embryonic neuro-development. Ann Anat. 2021 Jan;233:151617. doi: 10.1016/j.aanat.2020.151617. Epub 2020 Oct 21. PMID: 33098981.

Leonie Christin Thewes
Dept. of Neurology - Thiology
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf


PhD Thesis
Ferroptosis in development and diseases.

Supervisors

Publication:

  1. JNK Signalling Regulates Self-Renewal of Proliferative Urine-Derived Renal Progenitor Cells via Inhibition of Ferroptosis. Lisa Nguyen, Leonie Thewes, Michelle Westerhoff, Wasco Wruck, Andreas S Reichert, Carsten Berndt, James Adjaye. Cells. 2023 Sep 2;12(17):2197. doi: 10.3390/cells12172197. PubMed
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Laura Mara Toska
Dept. of Vascular and Endovascular Surgery
Heinrich-Heine-University Düsseldorf 40225 Düsseldorf


PhD Thesis
Impact of blood platelets in the progression of Alzheimer´s disease.

Supervisors

  • Prof. Dr. Patricia Hidalgo

  • Prof. Dr. Margitta Elvers

Publications

  1. Platelet pannexin-1 channels modulate neutrophil activation and migration but not the progression of abdominal aortic aneurysm. Lisa Maria Metz, Tobias Feige, Larissa de Biasi, Agnes Ehrenberg, Joscha Mulorz, Laura Mara Toska, Friedrich Reusswig, Christine Quast, Norbert Gerdes, Malte Kelm, Hubert Schelzig, Margitta Elvers. Front Mol Biosci. 2023 Mar 6:10:1111108. doi: 10.3389/fmolb.2023.1111108. eCollection 2023. PubMed

  2. Impact of Amyloid-β on Platelet Mitochondrial Function and Platelet-Mediated Amyloid Aggregation in Alzheimer's Disease. Lili Donner, Tobias Feige, Carolin Freiburg, Laura Mara Toska, Andreas S Reichert, Madhumita Chatterjee, Margitta Elvers. Int J Mol Sci. 2021 Sep 6;22(17):9633. doi: 10.3390/ijms22179633. PubMed

  3. Molecular Drivers of Platelet Activation: Unraveling Novel Targets for Anti-Thrombotic and Anti-Thrombo-Inflammatory Therapy. Madhumita Chatterjee, Agnes Ehrenberg, Laura Mara Toska, Lisa Maria Metz, Meike Klier, Irena Kruege, Friedrich Reusswig, Margitta Elvers. Int J Mol Sci. 2020 Oct 24;21(21):E7906. doi: 10.3390/ijms21217906. PubMed

  4. The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of β-amyloid. Lili Donner, Laura Mara Toska, Irena Krüger, Sandra Gröniger, Ruben Barroso, Alice Burleigh, Diego Mezzano, Susanne Pfeiler, Malte Kelm, Norbert Gerdes, Steve P Watson, Yi Sun, Margitta Elvers. Sci Signal. 2020 Aug 4;13(643):eaba9872. doi: 10.1126/scisignal.aba9872. PubMed

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