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PhD Researchers

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Sara Eitelmann
Institute of Neurobiology
Heinrich-Heine-University Düsseldorf 40225 Düsseldorf

PhD Thesis
Gap junctional coupling under ischemic conditions.

Supervisors

Publications

  1. Altered Gap Junction Network Topography in Mouse Models for Human Hereditary Deafness. Sara Eitelmann, Laura Petersilie, Christine R Rose, Jonathan Stephan. Int J Mol Sci. 2020 Oct 6;21(19):7376. doi: 10.3390/ijms21197376. PubMed
  2. A Vector-Based Method to Analyze the Topography of Glial Networks. Sara Eitelmann, Jan J Hirtz, Jonathan Stephan. Int J Mol Sci. 2019 Jun 10;20(11):2821. doi: 10.3390/ijms20112821. PubMed

Anna Engelke
Dept. of Neurology
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf

PhD Thesis
The role of FeS-Glutaredoxins and their cofactor in diseases.

Supervisors

Katharina Everaerts
Institute of Neurobiology
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf

PhD Thesis
Ion homeostasis and acute metabolic inhibition in the murine brain.

Supervisors

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Lisa Felix
Institute of Neurobiology
Heinrich-Heine-University Düsseldorf 40225 Düsseldorf

PhD Thesis
Spontaneous Na+ fluctuations in the neonatal mouse brain.

Supervisors

Publications

  1. On the Origin of Ultraslow Spontaneous Na + Fluctuations in Neurons of the Neonatal Forebrain. Carlos Perez, Lisa Felix, Simone Durry, Christine R Rose, Ghanim Ullah. J Neurophysiol. 2020 Nov 25. doi: 10.1152/jn.00373.2020. Online ahead of print. PubMed

  2. Correction: Felix, L.; Ziemens, D.; Seifert, G.; Rose, C.R. Spontaneous. Ultraslow Na + Fluctuations in the Neonatal Mouse Brain. Lisa Felix, Daniel Ziemens, Gerald Seifert, Christine R Rose.  Cells 2020, 9, 102. Cells. 2020 Oct 30;9(11):E2380. doi: 10.3390/cells9112380. PubMed

  3. Sodium Fluctuations in Astroglia and Their Potential Impact on Astrocyte Function. Lisa Felix, Andrea Delekate, Gabor C Petzold, Christine R Rose. Front Physiol. 2020 Aug 12;11:871. doi: 10.3389/fphys.2020.00871. eCollection 2020. PubMed

  4. Astrocytes of the early postnatal brain. Felix L, Stephan J, Rose CR. Eur J Neurosci. 2020 May 14. doi: 10.1111/ejn.14780. Online ahead of print. PMID: 32406559 PubMed

  5. Spontaneous Ultraslow Na+ Fluctuations in the Neonatal Mouse Brain. Felix L, Ziemens D, Seifert G, Rose CR. Cells. 2019 Dec 31;9(1):102. doi: 10.3390/cells9010102. PMID: 31906100 PubMed

  6. Astroglial Glutamate Signaling and Uptake in the Hippocampus. Rose CR, Felix L, Zeug A, Dietrich D, Reiner A, Henneberger C. Front Mol Neurosci. 2018 Jan 17;10:451. doi: 10.3389/fnmol.2017.00451. eCollection 2017. PMID: 29386994 PubMed

Joel Gruchot
Dept. of Neurology - Neuroregeneration
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf

PhD Thesis
Modulation of interactions between microglial cells and myelinated axons in response to the HERV-W envelope protein.

Supervisors

Publications

  1. Meeting report: "Human endogenous retroviruses: HERVs or transposable elements in autoimmune, chronic inflammatory and degenerative diseases or cancer", Lyon, France, november 5th and 6th 2019 - an MS scientist's digest. Kremer D, Weyers V, Gruchot J, Göttle P, Hartung HP, Perron H, Küry P. Mult Scler Relat Disord. 2020 Apr 8;42:102068. doi: 10.1016/j.msard.2020.102068. Online ahead of print. PMID: 32302965 PubMed

  2. Human endogenous retroviruses: ammunition for myeloid cells in neurodegenerative diseases? Gruchot J, Kremer D, Küry P. Neural Regen Res. 2020 Jun;15(6):1043-1044. doi: 10.4103/1673-5374.270311. PMID: 31823883 PubMed

  3. The Molecular Basis for Remyelination Failure in Multiple Sclerosis. Gruchot J, Weyers V, Göttle P, Förster M, Hartung HP, Küry P, Kremer D. Cells. 2019 Aug 3;8(8):825. doi: 10.3390/cells8080825. PMID: 31382620 PubMed

  4. Neural Cell Responses Upon Exposure to Human Endogenous Retroviruses. Gruchot J, Kremer D, Küry P. Front Genet. 2019 Jul 11;10:655. doi: 10.3389/fgene.2019.00655. eCollection 2019. PMID: 31354794 PubMed

  5. pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis. Kremer D, Gruchot J, Weyers V, Oldemeier L, Göttle P, Healy L, Ho Jang J, Kang T Xu Y, Volsko C, Dutta R, Trapp BD, Perron H, Hartung HP, Küry P. Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):15216-15225. doi: 10.1073/pnas.1901283116. Epub 2019 Jun 18. PMID: 31213545 PubMed

  6. Rescuing the negative impact of human endogenous retrovirus envelope protein on oligodendroglial differentiation and myelination. Göttle P, Förster M, Gruchot J, Kremer D, Hartung HP, Perron H, Küry P. Glia. 2019 Jan;67(1):160-170. doi: 10.1002/glia.23535. Epub 2018 Nov 14. PMID: 30430656 PubMed

Loretta Hamacher
Institute of Neuropathology - Molecular Neuropathology
Heinrich-Heine-University Düsseldorf 40225 Düsseldorf

PhD Thesis
The role of the metalloprotease ADAMTS1 in the generation of N-truncated Aß peptides in Alzheimer´s disease.

Supervisors

Dang Tri Le
Cell Biology
Leibniz Research Institute for Environmental Medicine
40225 Düsseldorf

PhD Thesis
Life span-resolved nanotoxicology: amyloid aggregation, neuronal targets and vulnerable age-groups in the nematode Caenorhabditis elegans.

Supervisors

Annette Limke
Cell Biology
Leibniz Research Institute for Environmental Medicine 40225 Düsseldorf

PhD Thesis
Chronic effects of environmental pollutants in the nematode Caenorhabditis elegans: Signaling pathways, aging processes and neurodegeneration.

Supervisors

Publications

  1. The Nucleus of Intestinal Cells of the Bacterivore Nematode Caenorhabditis elegans as a Sensitive Sensor of Environmental Pollutants. Annette Piechulek, Lutz Berwanger, Peter Hemmerich, Anna von Mikecz. Methods Mol Biol. 2020;2175:207-217. doi: 10.1007/978-1-0716-0763-3_15. PubMed

  2. Silica nanoparticles disrupt OPT-2/PEP-2-dependent trafficking of nutrient peptides in the intestinal epithelium. Piechulek A, Berwanger LC, von Mikecz A. Nanotoxicology. 2019 Oct;13(8):1133-1148. doi: 10.1080/17435390.2019.1643048. Epub 2019 Aug 9. PMID: 31340706 PubMed

  3. Life span-resolved nanotoxicology enables identification of age-associated neuromuscular vulnerabilities in the nematode Caenorhabditis elegans. Piechulek A, von Mikecz A. Environ Pollut. 2018 Feb;233:1095-1103. doi: 10.1016/j.envpol.2017.10.012. Epub 2017 Oct 12. PMID: 29031405 PubMed

  4. Effect of nanoparticles on the biochemical and behavioral aging phenotype of the nematode Caenorhabditis elegans. Scharf A, Piechulek A, von Mikecz A. ACS Nano. 2013 Dec 23;7(12):10695-703. doi: 10.1021/nn403443r. Epub 2013 Nov 23. PMID: 24256469  PubMed

Anastasia Manousi
Dept. of Neurology - Neuroregeneration
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf

PhD Thesis
High-Throuput screening for pharmacological compounds promoting p57kip2 nuclear shuttling and myelin repair.

Supervisor

Publications

  1. Heterogeneous fate choice of genetically modulated adult neural stem cells in gray and white matter of the central nervous system. Beyer F, Jadasz J, Samper Agrelo I, Schira-Heinen J, Groh J, Manousi A, Bütermann C, Estrada V, Reiche L, Cantone M, Vera J, Viganò F, Dimou L, Müller HW, Hartung HP, Küry P. Glia. 2020 Feb;68(2):393-406. doi: 10.1002/glia.23724. Epub 2019 Oct 21. PubMed

  2. Teriflunomide promotes oligodendroglial differentiation and myelination. Göttle P, Manousi A, Kremer D, Reiche L, Hartung HP, Küry P. J Neuroinflammation. 2018 Mar 13;15(1):76. doi: 10.1186/s12974-018-1110-z. PubMed

Soraia Martins
Institute for Stem Cell Research and Regenerative Medicine (ISRM)
Heinrich-Heine-University
40225 Düsseldorf

PhD Thesis
Molecular Mechansms underlying the cause of Human Nijmegen Breakage Syndrome using iPSCs-derived model.

Supervisor

Publications

  1. Generation of a Crigler-Najjar Syndrome Type I patient-derived induced pluripotent stem cell line CNS705 (HHUUKDi005-A). Nina Graffmann, Soraia Martins, Tijana Ljubikj, Julie Carole Matte, Martina Bohndorf, Wasco Wruck, James Adjaye. Stem Cell Res. 2021 Jan 12;51:102167. doi: 10.1016/j.scr.2021.102167. [Epub ahead of print] PubMed
  2. A stem cell based in vitro model of NAFLD enables the analysis of patient specific individual metabolic adaptations in response to a high fat diet and AdipoRon interference.  Nina Graffmann, Audrey Ncube, Soraia Martins, Aurelian Robert Fiszl, Philipp Reuther, Martina Bohndorf, Wasco Wruck, Mathias Beller, Constantin Czekelius, James Adjaye. Biol Open. 2021 Jan 25;10(1):bio054189.doi: 10.1242/bio.054189. PubMed
  3. Matrix Metalloproteinase 14 Mediates APP Proteolysis and Lysosomal Alterations Induced by Oxidative Stress in Human Neuronal Cells. Patricia Llorente, Soraia Martins, Isabel Sastre, Jesús Aldudo, María Recuero, James Adjaye, Maria J Bullido. Oxid Med Cell Longev. 2020 Nov 16;2020:5917187. doi: 10.1155/2020/5917187. eCollection 2020. PubMed
  4. IPSC-Derived Neuronal Cultures Carrying the Alzheimer's Disease Associated TREM2 R47H Variant Enables the Construction of an Aβ-Induced Gene Regulatory Network. Soraia Martins, Andreas Müller-Schiffmann, Lars Erichsen, Martina Bohndorf, Wasco Wruck, Kristel Sleegers, Christine Van Broeckhoven, Carsten Korth, James Adjaye. Int J Mol Sci. 2020 Jun 25;21(12):4516. doi: 10.3390/ijms21124516. PubMed
  5. AP-2 reduces amyloidogenesis by promoting BACE1 trafficking and degradation in neurons. Sujoy Bera, Santiago Camblor-Perujo, Elena Calleja Barca, Albert Negrete-Hurtado, Julia Racho, Elodie De Bruyckere, Christoph Wittich  , Nina Ellrich, Soraia Martins, James Adjaye, Natalia L Kononenko. EMBO Rep. 2020 Jun 4;21(6):e47954. doi: 10.15252/embr.201947954. Epub 2020 Apr 23. PubMed
  6. The FGF, TGFβ and WNT axis Modulate Self-renewal of Human SIX2 + Urine Derived Renal Progenitor Cells. Md Shaifur Rahman, Wasco Wruck, Lucas-Sebastian Spitzhorn, Lisa Nguyen, Martina Bohndorf, Soraia Martins, Fatima Asar, Audrey Ncube, Lars Erichsen, Nina Graffmann, James Adjaye. Sci Rep. 2020 Jan 20;10(1):739. doi: 10.1038/s41598-020-57723-2. PubMed
  7. Lymphoblast-derived integration-free iPSC line AD-TREM2-3 from a 74 year-old Alzheimer's disease patient expressing the TREM2 p.R47H variant. Soraia Martins, Hatice Yigit, Martina Bohndorf, Nina Graffmann, Aurelian Robert Fiszl, Wasco Wruck, Kristel Sleegers, Christine Van Broeckhoven, James Adjaye. Stem Cell Res. 2018 Jul;30:141-144. doi: 10.1016/j.scr.2018.05.018. Epub 2018 Jun 1. PubMed
  8. Lymphoblast-derived integration-free iPSC line AD-TREM2-1 from a 67year-old Alzheimer's disease patient expressing the TREM2 p.R47H variant. Soraia Martins, Hatice Yigit, Martina Bohndorf, Nina Graffmann, Aurelian Robert Fiszl, Wasco Wruck, Kristel Sleegers, Christine Van Broeckhoven, James Adjaye. Stem Cell Re. 2018 May;29:60-63. doi: 10.1016/j.scr.2018.03.011. Epub 2018 Mar 20. PubMed
  9. Lymphoblast-derived integration-free ISRM-CON9 iPS cell line from a 75year old female. Soraia Martins, Martina Bohndorf, Friederike Schröter, Fatima Assar, Wasco Wruck, Kristel Sleegers, Christine Van Broeckhoven, James Adjaye. Stem Cell Res. 2018 Jan;26:76-79. doi: 10.1016/j.scr.2017.12.007. Epub 2017 Dec 13. PubMed
  10. Nijmegen Breakage Syndrome fibroblasts and iPSCs: cellular models for uncovering disease-associated signaling pathways and establishing a screening platform for anti-oxidants. Barbara Mlody, Wasco Wruck, Soraia Martins, Karl Sperling, James Adjaye. Sci Rep. 2017 Aug 8;7(1):7516. doi: 10.1038/s41598-017-07905-2. PubMed
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Nils Pape
Institute of Neurobiology
Heinrich-Heine-University Düsseldorf 40225 Düsseldorf

PhD Thesis
Effects of energy deprivation on cellular ion homeostasis in the mouse brain.

Supervisors

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Laura Petersilie
Institute of Neurobiology
Heinrich-Heine-University Düsseldorf 40225 Düsseldorf

PhD Thesis
Influence of metabolic inhibition on the ion homeostasis of brain cells.

Supervisors

Publications

  1. Altered Gap Junction Network Topography in Mouse Models for Human Hereditary Deafness. Sara Eitelmann, Laura Petersilie, Christine R Rose, Jonathan Stephan. Int J Mol Sci. 2020 Oct 6;21(19):7376. doi: 10.3390/ijms21197376. PubMed

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Laura Reiche
Dept. of Neurology - Neuroregeneration
Heinrich-Heine-University Düsseldorf 40225 Düsseldorf

PhD Thesis
C21orf91 as a novel modulator of glial cell determination and differentiation.

Supervisors

Publications

  1. Heterogeneous fate choice of genetically modulated adult neural stem cells in gray and white matter of the central nervous system. Beyer F, Jadasz J, Samper Agrelo I, Schira-Heinen J, Groh J, Manousi A, Bütermann C, Estrada V, Reiche L, Cantone M, Vera J, Viganò F, Dimou L, Müller HW, Hartung HP, Küry P. Glia. 2020 Feb;68(2):393-406. doi: 10.1002/glia.23724. Epub 2019 Oct 21. PubMed

  2. Aberrant Oligodendrogenesis in Down Syndrome: Shift in Gliogenesis? Reiche L, Küry P, Göttle P. Cells. 2019 Dec 7;8(12). pii: E1591. doi: 10.3390/cells8121591. PubMed

  3. Teriflunomide promotes oligodendroglial differentiation and myelination. Göttle P, Manousi A, Kremer D, Reiche L, Hartung HP, Küry P. J Neuroinflammation. 2018 Mar 13;15(1):76. doi: 10.1186/s12974-018-1110-z. PubMed

Iria Samper Agrelo
Dept. of Neurology - Neuroregeneration
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf

Scholarship holder of the Christiane and Claudia Hempel-Foundation for stem cell research

PhD Thesis
Identification of mesenchymal stem cell-derived factors with prooligodendrogenic activities.

Supervisors

Publications

  1. Secretome Analysis of Mesenchymal Stem Cell Factors Fostering Oligodendroglial Differentiation of Neural Stem Cells In Vivo. Iria Samper Agrelo, Jessica Schira-Heinen, Felix Beyer, Janos Groh, Christine Bütermann, Veronica Estrada, Gereon Poschmann, Ana Bribian, Janusz J Jadasz, Laura Lopez-Mascaraque, David Kremer, Rudolf Martini, Hans Werner Müller, Hans Peter Hartung, James Adjaye, Kai Stühler, Patrick Küry. Int J Mol Sci. 2020 Jun 18;21(12):E4350.doi: 10.3390/ijms21124350. PubMed
  2. Heterogeneous fate choice of genetically modulated adult neural stem cells in gray and white matter of the central nervous system. Beyer F, Jadasz J, Samper Agrelo I, Schira-Heinen J, Groh J, Manousi A, Bütermann C, Estrada V, Reiche L, Cantone M, Vera J, Viganò F, Dimou L, Müller HW, Hartung HP, Küry P. Glia. 2020 Feb;68(2):393-406. doi: 10.1002/glia.23724. Epub 2019 Oct 21. PubMed
  3. Do Neural Stem Cells Have a Choice? Heterogenic Outcome of Cell Fate Acquisition in Different Injury Models. Beyer F, Samper Agrelo I, Küry P. Int J Mol Sci. 2019 Jan 21;20(2). pii: E455. doi: 10.3390/ijms20020455. PubMed
  4. Human mesenchymal factors induce rat hippocampal- and human neural stem cell dependent oligodendrogenesis. Jadasz JJ, Tepe L, Beyer F, Samper Agrelo I, Akkermann R, Spitzhorn LS, Silva ME, Oreffo ROC, Hartung HP, Prigione A, Rivera FJ, Adjaye J, Küry P. Glia. 2018 Jan;66(1):145-160. doi: 10.1002/glia.23233. Epub 2017 Sep 22. PubMed

Markley Silva Oliveira Junior
Dept. of Neurology - Neuroregeneration
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf

PhD Thesis
Stimulating transcriptional networks of forebrain neural stem cells using in silico discovery approaches for regeneration in demyelinating diseases.

Supervisors

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Laura Mara Toska
Dept. of Vascular and Endovascular Surgery
Heinrich-Heine-University Düsseldorf 40225 Düsseldorf

PhD Thesis
Impact of blood platelets in the progression of Alzheimer´s disease.

Supervisors

  • Prof. Dr. Patricia Hidalgo

  • Prof. Dr. Margitta Elvers

Publications

  1. Molecular Drivers of Platelet Activation: Unraveling Novel Targets for Anti-Thrombotic and Anti-Thrombo-Inflammatory Therapy. Madhumita Chatterjee, Agnes Ehrenberg, Laura Mara Toska, Lisa Maria Metz, Meike Klier, Irena Kruege, Friedrich Reusswig, Margitta Elvers. Int J Mol Sci. 2020 Oct 24;21(21):E7906. doi: 10.3390/ijms21217906. PubMed

  2. The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of β-amyloid. Lili Donner, Laura Mara Toska, Irena Krüger, Sandra Gröniger, Ruben Barroso, Alice Burleigh, Diego Mezzano, Susanne Pfeiler, Malte Kelm, Norbert Gerdes, Steve P Watson, Yi Sun, Margitta Elvers. Sci Signal. 2020 Aug 4;13(643):eaba9872. doi: 10.1126/scisignal.aba9872. PubMed

Else van Gerresheim
Institute of Neuropathology
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf

PhD Thesis
Abeta prion spreading: Correlation with behavior and prion protein cofactor.

Supervisor

Publication

  1. The interaction of insoluble Amyloid-β with soluble Amyloid-β dimers decreases Amyloid-β plaque numbers. Else F van Gerresheim, Arne Herring, Lothar Gremer, Andreas Müller-Schiffmann, Kathy Keyvani, Carsten Korth. Neuropathol Appl Neurobiol. 2020 Dec 18.doi: 10.1111/nan.12685. Online ahead of print. PubMed

Andres Vargas-Toscano
Dept. of Neurosurgery
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf

PhD Thesis
Personalized brain tumor therapy approaches on glioblastoma stem cell models.

Supervisors

Publications

  1. Rapalink-1 Targets Glioblastoma Stem Cells and Acts Synergistically with Tumor Treating Fields to Reduce Resistance against Temozolomide. Andres Vargas-Toscano, Ann-Christin Nickel, Guanzhang Li, Marcel Alexander Kamp, Sajjad Muhammad, Gabriel Leprivier, Ellen Fritsche, Roger A Barker, Michael Sabel, Hans-Jakob Steiger, Wei Zhang, Daniel Hänggi, Ulf Dietrich Kahlert. Cancers (Basel). 2020 Dec 21;12(12):3859. doi: 10.3390/cancers12123859. PubMed

  2. Robot Technology Identifies a Parkinsonian Therapeutics Repurpose to Target Stem Cells of Glioblastoma. Andres Vargas-Toscano, Dilaware Khan, Ann-Christin Nickel, Michael Hewera, Marcel Alexander Kamp, Igor Fischer, Hans-Jakob Steiger, Wei Zhang, Sajjad Muhammad, Daniel Hänggi, Ulf Dietrich Kahlert. CNS Oncol. 2020 May 28.doi: 10.2217/cns-2020-0004. Online ahead of print. PubMed

  3. Influence of synthesis methods on the internalization of fluorescent gold nanoparticles into glioblastoma stem-like cells. Giesen B, Nickel AC, Garzón Manjón A, Vargas Toscano A, Scheu C, Kahlert UD, Janiak C. J Inorg Biochem. 2020 Feb;203:110952. doi: 10.1016/j.jinorgbio.2019.110952. Epub 2019 Nov 23. PMID: 31794896 PubMed

  4. Seizure frequency reduction after posteromedial hypothalamus deep brain stimulation in drug-resistant epilepsy associated with intractable aggressive behavior. Benedetti-Isaac JC, Torres-Zambrano M, Vargas-Toscano A, Perea-Castro E, Alcalá-Cerra G, Furlanetti LL, Reithmeier T, Tierney TS, Anastasopoulos C, Fonoff ET, Contreras Lopez WO. Epilepsia. 2015 Jul;56(7):1152-61. doi: 10.1111/epi.13025. Epub 2015 Jul 4. PMID: 26146753 PubMed

Christina Wilms
Dept. of Neurology - Thiology
Heinrich-Heine-University Düsseldorf
40225 Düsseldorf

PhD Thesis
Redox-abhängige Differenzierung und Dedifferenzierung.

Supervisors

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Alexandra Ziemski
Institute for Physical Biology
Heinrich-Heine-University Düsseldorf 40225 Düsseldorf

Scholarship holder of the Christiane and Claudia Hempel-Foundation for stem cell research

PhD Thesis
Blood-Based Single Particle Analysis for Diagnosis of Alzheimer‘s Disease.

Supervisors

Co-Supervisor:

  • Dr. Oliver Bannach

Publication

  1. Oral and intravenous transmission of α-synuclein fibrils to mice. Lohmann S, Bernis ME, Tachu BJ, Ziemski A, Grigoletto J, Tamgüney G. Acta Neuropathol. 2019 Oct;138(4):515-533. doi: 10.1007/s00401-019-02037-5. Epub 2019 Jun 22. PMID: 31230104 PubMed

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